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Aliases for UTS2 Gene

Aliases for UTS2 Gene

  • Urotensin 2 2 3 5
  • Urotensin II 3 4
  • Prepro U-II 2 3
  • U-II 3 4
  • UII 3 4
  • Urotensin-2 3
  • PRO1068 3
  • UCN2 3

External Ids for UTS2 Gene

Previous GeneCards Identifiers for UTS2 Gene

  • GC01M007485
  • GC01M007716
  • GC01M007617
  • GC01M007841
  • GC01M007055

Summaries for UTS2 Gene

Entrez Gene Summary for UTS2 Gene

  • This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UTS2 Gene

UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include Portal Hypertension and Congestive Heart Failure. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for UTS2 Gene

  • Highly potent vasoconstrictor.

Tocris Summary for UTS2 Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2 Gene

Additional gene information for UTS2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2 Gene

Genomics for UTS2 Gene

GeneHancer (GH) Regulatory Elements for UTS2 Gene

Promoters and enhancers for UTS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I007912 Enhancer 0.8 Ensembl ENCODE 584.4 +0.4 446 1 HDAC1 CBFA2T3 ZEB2 HDAC2 POLR2A ZNF341 ZNF512 KDM1A SPI1 UTS2 TNFRSF9 VAMP3 PER3 SLC45A1 ENSG00000238290 ENSG00000236266
GH01I007853 Promoter 0.8 EPDnew 550.2 +60.5 60525 0.1 OSR2 MEIS2 IKZF1 CBFA2T3 CBFA2T2 KDM1A TCF7L2 UTS2 ENSG00000236266
GH01I007940 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 17.8 -28.0 -27991 3.2 HDGF PKNOX1 ATF1 ARNT YBX1 ZNF280A ARID2 ZNF143 ATF7 FOS GC01P007941 TNFRSF9 ENSG00000270330 UTS2 RERE LOC100129776
GH01I007902 Enhancer 1.1 Ensembl ENCODE 17.2 +10.7 10675 1.1 HDGF ZNF121 GLIS2 ARID2 ZNF143 SP3 NCOA1 REST ZNF610 GLIS1 UTS2 PER3 VAMP3 PARK7 ENSG00000238290 ENSG00000236266
GH01I008002 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 -91.4 -91351 4.3 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 FOS ENSG00000238290 PARK7 ERRFI1 SLC45A1 LINC01714 RNU1-7P TNFRSF9 UTS2 PER3 GC01P008012
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UTS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UTS2 gene promoter:

Genomic Locations for UTS2 Gene

Genomic Locations for UTS2 Gene
70,528 bases
Minus strand

Genomic View for UTS2 Gene

Genes around UTS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2 Gene

Proteins for UTS2 Gene

  • Protein details for UTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5H8X7
    • Q6UXF6
    • Q9UKP7

    Protein attributes for UTS2 Gene

    124 amino acids
    Molecular mass:
    14296 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UTS2 Gene


neXtProt entry for UTS2 Gene

Post-translational modifications for UTS2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UTS2 Gene

Domains & Families for UTS2 Gene

Gene Families for UTS2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for UTS2 Gene


Suggested Antigen Peptide Sequences for UTS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the urotensin-2 family.
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2: view

Function for UTS2 Gene

Molecular function for UTS2 Gene

UniProtKB/Swiss-Prot Function:
Highly potent vasoconstrictor.

Phenotypes From GWAS Catalog for UTS2 Gene

Gene Ontology (GO) - Molecular Function for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10499587
GO:0005179 hormone activity IEA,TAS --
genes like me logo Genes that share ontologies with UTS2: view
genes like me logo Genes that share phenotypes with UTS2: view

Animal Models for UTS2 Gene

MGI Knock Outs for UTS2:

Animal Model Products

miRNA for UTS2 Gene

miRTarBase miRNAs that target UTS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTS2 Gene

Localization for UTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 10499587
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with UTS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTS2 Gene

Pathways & Interactions for UTS2 Gene

genes like me logo Genes that share pathways with UTS2: view

Gene Ontology (GO) - Biological Process for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 10499587
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007268 chemical synaptic transmission TAS 10499587
GO:0008217 regulation of blood pressure TAS,IEA --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with UTS2: view

No data available for SIGNOR curated interactions for UTS2 Gene

Drugs & Compounds for UTS2 Gene

(25) Drugs for UTS2 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SB 657510 Pharma Selective urotensin-II (UT) receptor antagonist 0
Urotensin II (human) Pharma Endogenous vasoactive agonist for the UT receptor 0

(13) Additional Compounds for UTS2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride

(5) Tocris Compounds for UTS2 Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist 477313-09-0
[Orn5]-URP Urotensin-II (UT) receptor antagonist 782485-03-4
SB 657510 Selective urotensin-II (UT) receptor antagonist 474960-44-6
UFP 803 Urotensin-II (UT) antagonist 879497-82-2
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor 251293-28-4
genes like me logo Genes that share compounds with UTS2: view

Transcripts for UTS2 Gene

Unigene Clusters for UTS2 Gene

Urotensin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -

Relevant External Links for UTS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTS2 Gene

mRNA differential expression in normal tissues according to GTEx for UTS2 Gene

This gene is overexpressed in Whole Blood (x11.3), Brain - Spinal cord (cervical c-1) (x9.2), Adrenal Gland (x6.1), and Brain - Hypothalamus (x5.6).

Protein differential expression in normal tissues from HIPED for UTS2 Gene

This gene is overexpressed in Stomach (10.0) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTS2 Gene

Protein tissue co-expression partners for UTS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UTS2 Gene:


SOURCE GeneReport for Unigene cluster for UTS2 Gene:


mRNA Expression by UniProt/SwissProt for UTS2 Gene:

Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for UTS2 Gene

  • Nervous system(4.6)
  • Heart(2.4)
  • Muscle(2.3)
  • Blood(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with UTS2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UTS2 Gene

Orthologs for UTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTS2 33
  • 81.57 (n)
(Canis familiaris)
Mammalia UTS2 33
  • 76.15 (n)
(Pan troglodytes)
Mammalia UTS2 34
  • 70 (a)
(Rattus norvegicus)
Mammalia Uts2 33
  • 67.76 (n)
(Mus musculus)
Mammalia Uts2 33 16 34
  • 65.57 (n)
(Ornithorhynchus anatinus)
Mammalia UTS2 34
  • 43 (a)
(Monodelphis domestica)
Mammalia UTS2 34
  • 42 (a)
(Gallus gallus)
Aves UTS2 34
  • 40 (a)
Species where no ortholog for UTS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2 Gene

Gene Tree for UTS2 (if available)
Gene Tree for UTS2 (if available)

Paralogs for UTS2 Gene

No data available for Paralogs for UTS2 Gene

Variants for UTS2 Gene

Sequence variations from dbSNP and Humsavar for UTS2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009758 -- 7,889,996(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000107481 -- 7,906,582(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000108269 -- 7,865,948(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000108716 -- 7,895,944(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000200069 -- 7,890,971(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UTS2 Gene

Variant ID Type Subtype PubMed ID
esv3585131 CNV loss 21293372
esv2660700 CNV deletion 23128226

Variation tolerance for UTS2 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTS2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2 Gene

Disorders for UTS2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for UTS2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
portal hypertension
  • hypertension, portal
congestive heart failure
  • cardiac failure congestive
liver cirrhosis
  • cirrhosis
hepatic vascular disease
  • vascular disorder of liver
pulmonary hypertension
  • primary pulmonary hypertension
- elite association - COSMIC cancer census association via MalaCards
Search UTS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTS2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UTS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2 Gene

Publications for UTS2 Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames RS … Douglas SA (Nature 1999) 2 3 4 22 58
  2. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PMID: 9861051) Coulouarn Y … Vaudry H (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  3. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. (PMID: 15476949) Suzuki S … Oka Y (Peptides 2004) 3 22 44 58
  4. Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects. (PMID: 12830381) Wenyi Z … Oka Y (Diabetologia 2003) 3 22 44 58
  5. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. (PMID: 20428787) Liu D … Wang Y (International journal of molecular medicine 2010) 3 22 58

Products for UTS2 Gene

Sources for UTS2 Gene

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