Aliases for UTP3 Gene

Aliases for UTP3 Gene

  • UTP3 Small Subunit Processome Component 2 3 5
  • Charged Amino Acid-Rich Leucine Zipper 1 3 4
  • Something About Silencing Protein 10 3 4
  • Disrupter Of Silencing SAS10 3 4
  • Disrupter Of Silencing 10 2 3
  • UTP3 Homolog 3 4
  • CRLZ1 3 4
  • SAS10 3 4
  • CRL1 3 4
  • UTP3, Small Subunit (SSU) Processome Component, Homolog (S. Cerevisiae) 2
  • UTP3, Small Subunit Processome Component Homolog 3
  • Charged Amino Acid Rich Leucine Zipper 1 Homolog 3

External Ids for UTP3 Gene

Previous GeneCards Identifiers for UTP3 Gene

  • GC04P071775
  • GC04P071554
  • GC04P067358

Summaries for UTP3 Gene

GeneCards Summary for UTP3 Gene

UTP3 (UTP3 Small Subunit Processome Component) is a Protein Coding gene. Diseases associated with UTP3 include Enterocele and Prolapse Of Female Genital Organ. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. An important paralog of this gene is NGDN.

UniProtKB/Swiss-Prot Summary for UTP3 Gene

  • Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Gene Wiki entry for UTP3 Gene

Additional gene information for UTP3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UTP3 Gene

Genomics for UTP3 Gene

GeneHancer (GH) Regulatory Elements for UTP3 Gene

Promoters and enhancers for UTP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J070687 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.2 1159 5.1 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 MYC TCF12 USF1 UTP3 lnc-JCHAIN-3 JCHAIN lnc-UTP3-1
GH04J070901 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.3 +214.4 214422 3.4 CTCF NRF1 POLR2G PHF8 PHB2 ZFX ZNF639 ZIC2 POLR2A ZBTB11 MOB1B lnc-GRSF1-2 DCK GRSF1 UTP3 JCHAIN piR-59760
GH04J070721 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 +35.2 35193 4.7 EP300 ZSCAN5C USF1 JUND FOS ZNF639 ZIC2 TRIM28 REST RFX1 RUFY3 UTP3 JCHAIN ENSG00000272986 RF00017-4324
GH04J070836 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 10.1 +150.3 150322 4 EP300 SIN3A NRF1 POLR2G SP1 ZFX ZIC2 REST POLR2A AFF1 lnc-JCHAIN-2 lnc-RUFY3-1 UTP3 JCHAIN RUFY3 DCK GRSF1 FJ601684-345
GH04J070733 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 +47.2 47203 4.8 CTCF OSR2 KLF9 CEBPB CBFB ZNF384 SMC3 IRF1 CEBPG NBN RUFY3 RNU6-520P RNU6-784P UTP3 JCHAIN RF00017-4324 ENSG00000272986
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UTP3

Top Transcription factor binding sites by QIAGEN in the UTP3 gene promoter:
  • AML1a
  • CUTL1
  • Lmo2
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • STAT3
  • STAT5A

Genomic Locations for UTP3 Gene

Genomic Locations for UTP3 Gene
chr4:70,688,479-70,690,551
(GRCh38/hg38)
Size:
2,073 bases
Orientation:
Plus strand
chr4:71,554,196-71,556,268
(GRCh37/hg19)
Size:
2,073 bases
Orientation:
Plus strand

Genomic View for UTP3 Gene

Genes around UTP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP3 Gene

Proteins for UTP3 Gene

  • Protein details for UTP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ2-SAS10_HUMAN
    Recommended name:
    Something about silencing protein 10
    Protein Accession:
    Q9NQZ2
    Secondary Accessions:
    • Q6FI82

    Protein attributes for UTP3 Gene

    Size:
    479 amino acids
    Molecular mass:
    54558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTP3 Gene

Post-translational modifications for UTP3 Gene

Other Protein References for UTP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP3 Gene

Domains & Families for UTP3 Gene

Gene Families for UTP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UTP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP3 Gene

GenScript: Design optimal peptide antigens:
  • UTP3 homolog (SAS10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQZ2

UniProtKB/Swiss-Prot:

SAS10_HUMAN :
  • Belongs to the SAS10 family.
Family:
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with UTP3: view

Function for UTP3 Gene

Molecular function for UTP3 Gene

UniProtKB/Swiss-Prot Function:
Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Phenotypes From GWAS Catalog for UTP3 Gene

Gene Ontology (GO) - Molecular Function for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UTP3: view
genes like me logo Genes that share phenotypes with UTP3: view

Animal Model Products

CRISPR Products

miRNA for UTP3 Gene

miRTarBase miRNAs that target UTP3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP3 Gene

Localization for UTP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IBA 21873635
genes like me logo Genes that share ontologies with UTP3: view

Pathways & Interactions for UTP3 Gene

genes like me logo Genes that share pathways with UTP3: view

Gene Ontology (GO) - Biological Process for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0006325 chromatin organization IEA --
GO:0006364 rRNA processing TAS --
GO:0007275 multicellular organism development IEA --
GO:0007420 brain development IEA,ISS --
genes like me logo Genes that share ontologies with UTP3: view

No data available for SIGNOR curated interactions for UTP3 Gene

Drugs & Compounds for UTP3 Gene

No Compound Related Data Available

Transcripts for UTP3 Gene

mRNA/cDNA for UTP3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTP3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP3 Gene

No ASD Table

Relevant External Links for UTP3 Gene

GeneLoc Exon Structure for
UTP3

Expression for UTP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UTP3 Gene

Protein differential expression in normal tissues from HIPED for UTP3 Gene

This gene is overexpressed in Adrenal (14.3), Peripheral blood mononuclear cells (11.2), Lung (8.5), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UTP3 Gene



Protein tissue co-expression partners for UTP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UTP3

SOURCE GeneReport for Unigene cluster for UTP3 Gene:

Hs.322901
genes like me logo Genes that share expression patterns with UTP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP3 Gene

Orthologs for UTP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP3 31 30
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UTP3 31 30
  • 88.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UTP3 31 30
  • 87.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Utp3 17 31 30
  • 82.87 (n)
rat
(Rattus norvegicus)
Mammalia Utp3 30
  • 82.41 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP3 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP3 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP3 31 30
  • 60.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UTP3 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7619 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2574 30
zebrafish
(Danio rerio)
Actinopterygii utp3 31 30
  • 57.06 (n)
OneToOne
Dr.17306 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5012 30
fruit fly
(Drosophila melanogaster)
Insecta Sas10 31 30
  • 47.48 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002960 30
  • 46.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAS10 33 31
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5711 31
  • 34 (a)
OneToOne
Species where no ortholog for UTP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UTP3 Gene

ENSEMBL:
Gene Tree for UTP3 (if available)
TreeFam:
Gene Tree for UTP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UTP3: view image

Paralogs for UTP3 Gene

Paralogs for UTP3 Gene

genes like me logo Genes that share paralogs with UTP3: view

Variants for UTP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UTP3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
782092 Benign: not provided 70,689,790(+) T/A MISSENSE_VARIANT
789999 Benign: not provided 70,688,745(+) C/T MISSENSE_VARIANT
790000 Benign: not provided 70,688,761(+) T/C SYNONYMOUS_VARIANT
rs16845385 - p.Thr23Met

Additional dbSNP identifiers (rs#s) for UTP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for UTP3 Gene

Variant ID Type Subtype PubMed ID
esv3600939 CNV gain 21293372
nsv1012495 CNV gain 25217958
nsv829965 CNV gain 17160897

Variation tolerance for UTP3 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP3 Gene

Disorders for UTP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UTP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
enterocele
  • vaginal enterocele
prolapse of female genital organ
- elite association - COSMIC cancer census association via MalaCards
Search UTP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTP3

genes like me logo Genes that share disorders with UTP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTP3 Gene

Publications for UTP3 Gene

  1. Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome. (PMID: 28813493) Sá-Moura B … Hurt E (PloS one 2017) 2 3 54
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54

Products for UTP3 Gene

Sources for UTP3 Gene