Aliases for UTP25 Gene

Aliases for UTP25 Gene

  • UTP25 Small Subunit Processor Component 2 3 5
  • Digestive Organ Expansion Factor Homolog 3 4
  • C1orf107 3 4
  • DEF 3 4
  • Digestive Organ Expansion Factor Homolog (Zebrafish) 2
  • Digestive-Organ Expansion Factor Homolog 3
  • UTP25, Small Subunit Processor Component 2
  • Chromosome 1 Open Reading Frame 107 2
  • DJ434O14.5 3
  • DIEXF 3

External Ids for UTP25 Gene

Previous HGNC Symbols for UTP25 Gene

  • C1orf107
  • DIEXF

Summaries for UTP25 Gene

GeneCards Summary for UTP25 Gene

UTP25 (UTP25 Small Subunit Processor Component) is a Protein Coding gene. Diseases associated with UTP25 include Ethmoid Sinus Adenocarcinoma and Ethmoid Sinus Cancer. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

UniProtKB/Swiss-Prot Summary for UTP25 Gene

  • Regulates the p53 pathway to control the expansion growth of digestive organs.

Additional gene information for UTP25 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UTP25 Gene

Genomics for UTP25 Gene

GeneHancer (GH) Regulatory Elements for UTP25 Gene

Promoters and enhancers for UTP25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTP25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UTP25

Genomic Locations for UTP25 Gene

Genomic Locations for UTP25 Gene
chr1:209,827,967-209,857,565
(GRCh38/hg38)
Size:
29,599 bases
Orientation:
Plus strand
chr1:210,001,312-210,030,910
(GRCh37/hg19)
Size:
29,599 bases
Orientation:
Plus strand

Genomic View for UTP25 Gene

Genes around UTP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP25 Gene

Proteins for UTP25 Gene

  • Protein details for UTP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ4-DIEXF_HUMAN
    Recommended name:
    Digestive organ expansion factor homolog
    Protein Accession:
    Q68CQ4
    Secondary Accessions:
    • O75992
    • Q4VY00
    • Q63HL9

    Protein attributes for UTP25 Gene

    Size:
    756 amino acids
    Molecular mass:
    87055 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTP25 Gene

Post-translational modifications for UTP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTP25 Gene

No data available for DME Specific Peptides for UTP25 Gene

Domains & Families for UTP25 Gene

Gene Families for UTP25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UTP25 Gene

Suggested Antigen Peptide Sequences for UTP25 Gene

GenScript: Design optimal peptide antigens:
  • Digestive organ expansion factor homolog (DIEXF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68CQ4

UniProtKB/Swiss-Prot:

DIEXF_HUMAN :
  • Belongs to the def family.
Family:
  • Belongs to the def family.
genes like me logo Genes that share domains with UTP25: view

Function for UTP25 Gene

Molecular function for UTP25 Gene

UniProtKB/Swiss-Prot Function:
Regulates the p53 pathway to control the expansion growth of digestive organs.

Phenotypes From GWAS Catalog for UTP25 Gene

Gene Ontology (GO) - Molecular Function for UTP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 23357851
GO:0019843 rRNA binding IBA 21873635
GO:0034511 U3 snoRNA binding IBA 21873635
genes like me logo Genes that share ontologies with UTP25: view
genes like me logo Genes that share phenotypes with UTP25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTP25

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP25 Gene

Localization for UTP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP25 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP25 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UTP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 23357851
GO:0032040 small-subunit processome IBA 21873635
genes like me logo Genes that share ontologies with UTP25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTP25 Gene

Pathways & Interactions for UTP25 Gene

genes like me logo Genes that share pathways with UTP25: view

Gene Ontology (GO) - Biological Process for UTP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0006364 rRNA processing TAS --
GO:0007275 multicellular organism development IEA --
GO:0030163 protein catabolic process IMP 23357851
GO:0031648 protein destabilization IMP 23357851
genes like me logo Genes that share ontologies with UTP25: view

No data available for SIGNOR curated interactions for UTP25 Gene

Drugs & Compounds for UTP25 Gene

(14) Drugs for UTP25 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2E)-3-(3,4-DIHYDROXYPHENYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]ACRYLAMIDE Experimental Pharma Target 0
(S)-2-(Phosphonoxy)Caproyl-L-Leucyl-P-Nitroanilide Experimental Pharma Target 0
[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL Experimental Pharma Target, Target 0
2-(3,4-Dihydro-3-Oxo-2h-Benzo[B][1,4]Thiazin-2-Yl)-N-Hydroxyacetamide Experimental Pharma Target 0
2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with UTP25: view

Transcripts for UTP25 Gene

mRNA/cDNA for UTP25 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTP25

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP25 Gene

No ASD Table

Relevant External Links for UTP25 Gene

GeneLoc Exon Structure for
UTP25

Expression for UTP25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UTP25

Evidence on tissue expression from TISSUES for UTP25 Gene

  • Nervous system(2.7)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP25 Gene

Orthologs for UTP25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIEXF 31 30
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DIEXF 31 30
  • 88.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DIEXF 31 30
  • 87.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Diexf 30
  • 85.39 (n)
mouse
(Mus musculus)
Mammalia Diexf 31 30
  • 85.21 (n)
OneToOne
Utp25 17
oppossum
(Monodelphis domestica)
Mammalia DIEXF 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIEXF 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIEXF 31 30
  • 68.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DIEXF 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia diexf 30
  • 67.42 (n)
Str.11330 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16819 30
zebrafish
(Danio rerio)
Actinopterygii diexf 31 30
  • 59.54 (n)
OneToOne
dj434o14.5l 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011170 30
  • 51.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3735 31 30
  • 51.63 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y41C4A.9 31
  • 31 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08229g 30
  • 46.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL209C 30
  • 45.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP25 31 30
  • 44.99 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NOF1 30
  • 49.38 (n)
rice
(Oryza sativa)
Liliopsida Os05g0295100 30
  • 48.95 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01022 30
  • 50.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1827.01c 30
  • 46.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1540 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1540 30
Species where no ortholog for UTP25 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP25 Gene

ENSEMBL:
Gene Tree for UTP25 (if available)
TreeFam:
Gene Tree for UTP25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UTP25: view image

Paralogs for UTP25 Gene

No data available for Paralogs for UTP25 Gene

Variants for UTP25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UTP25 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs585627 - p.Gln67Glu

Additional dbSNP identifiers (rs#s) for UTP25 Gene

Variation tolerance for UTP25 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UTP25 Gene

Disorders for UTP25 Gene

MalaCards: The human disease database

(4) MalaCards diseases for UTP25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ethmoid sinus adenocarcinoma
  • adenocarcinoma of ethmoid sinus
ethmoid sinus cancer
  • malignant neoplasm of ethmoidal sinus
cardiomyopathy, dilated, 1g
  • cmd1g
tietz albinism-deafness syndrome
  • tads
- elite association - COSMIC cancer census association via MalaCards
Search UTP25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTP25

genes like me logo Genes that share disorders with UTP25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTP25 Gene

Publications for UTP25 Gene

  1. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. (PMID: 16322560) Chen J … Peng J (Genes & development 2005) 2 3 23 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54

Products for UTP25 Gene

Sources for UTP25 Gene