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Aliases for UTP20 Gene

Aliases for UTP20 Gene

  • UTP20, Small Subunit Processome Component 2 3 5
  • Down-Regulated In Metastasis Protein 3 4
  • Down Regulated In Metastasis 2 3
  • Novel Nucleolar Protein 73 3 4
  • NNP73 3 4
  • DRIM 3 4
  • UTP20, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP20, Small Subunit (SSU) Processome Component, Homolog 3
  • UTP20 Small Subunit (SSU) Processome Component 3
  • Small Subunit Processome Component 20 Homolog 3
  • Protein Key-1A6 4
  • 1A6/DRIM 3

External Ids for UTP20 Gene

Previous GeneCards Identifiers for UTP20 Gene

  • GC12P100198
  • GC12P101673
  • GC12P098734

Summaries for UTP20 Gene

Entrez Gene Summary for UTP20 Gene

  • UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]

GeneCards Summary for UTP20 Gene

UTP20 (UTP20, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for UTP20 Gene

  • Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Gene Wiki entry for UTP20 Gene

Additional gene information for UTP20 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP20 Gene

Genomics for UTP20 Gene

GeneHancer (GH) Regulatory Elements for UTP20 Gene

Promoters and enhancers for UTP20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I101279 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 567.7 +0.1 92 2 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 SLC30A9 UTP20 ARL1 ENSG00000257222 NUP37
GH12I102060 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.1 +781.6 781566 2.1 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 WASHC3 ENSG00000257222 UTP20 NUP37 PARPBP NENFP2
GH12I101875 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.3 +597.2 597239 4.5 HDGF ARNT ARID4B SIN3A DMAP1 POLR2B ZNF207 ZNF143 ZNF263 SP3 DRAM1 ENSG00000257222 CHPT1 UTP20 PARPBP GNPTAB PIR46358
GH12I100500 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 12.9 -776.5 -776524 5.7 FOXA2 RXRA TAF1 MAX REST RAD21 FOXA1 GABPA YY1 JUND NR1H4 UTP20 SCYL2 ENSG00000271177
GH12I101051 Enhancer 1.1 Ensembl ENCODE 12.9 -227.7 -227710 2.7 FEZF1 ZNF2 GLIS2 ZNF213 FOS SP3 TSHZ1 ZNF518A NFIL3 GLIS1 ACTR6 UTP20 ENSG00000257543 GAS2L3 SNX5P2 ENSG00000258007 ANO4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UTP20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UTP20 gene promoter:

Genomic Locations for UTP20 Gene

Genomic Locations for UTP20 Gene
chr12:101,280,109-101,386,619
(GRCh38/hg38)
Size:
106,511 bases
Orientation:
Plus strand
chr12:101,673,887-101,780,397
(GRCh37/hg19)

Genomic View for UTP20 Gene

Genes around UTP20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP20 Gene

Proteins for UTP20 Gene

  • Protein details for UTP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75691-UTP20_HUMAN
    Recommended name:
    Small subunit processome component 20 homolog
    Protein Accession:
    O75691
    Secondary Accessions:
    • Q9H3H4

    Protein attributes for UTP20 Gene

    Size:
    2785 amino acids
    Molecular mass:
    318385 Da
    Quaternary structure:
    • Interacts with FBL and PPP1R26.
    SequenceCaution:
    • Sequence=AAG35208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UTP20 Gene

Post-translational modifications for UTP20 Gene

No Post-translational modifications

Other Protein References for UTP20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP20 Gene

Domains & Families for UTP20 Gene

Gene Families for UTP20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UTP20 Gene

Suggested Antigen Peptide Sequences for UTP20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75691

UniProtKB/Swiss-Prot:

UTP20_HUMAN :
  • Belongs to the UTP20 family.
Family:
  • Belongs to the UTP20 family.
genes like me logo Genes that share domains with UTP20: view

Function for UTP20 Gene

Molecular function for UTP20 Gene

UniProtKB/Swiss-Prot Function:
Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Phenotypes From GWAS Catalog for UTP20 Gene

Gene Ontology (GO) - Molecular Function for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 16053918
genes like me logo Genes that share ontologies with UTP20: view
genes like me logo Genes that share phenotypes with UTP20: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP20 Gene

Localization for UTP20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP20 Gene

Nucleus, nucleolus. Note=Colocalizes with NCL in the nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP20 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus ISS 15590835
GO:0005737 cytoplasm ISS 17652137
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with UTP20: view

Pathways & Interactions for UTP20 Gene

genes like me logo Genes that share pathways with UTP20: view

Gene Ontology (GO) - Biological Process for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 15590835
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with UTP20: view

No data available for SIGNOR curated interactions for UTP20 Gene

Drugs & Compounds for UTP20 Gene

No Compound Related Data Available

Transcripts for UTP20 Gene

Unigene Clusters for UTP20 Gene

UTP20, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP20 Gene

No ASD Table

Relevant External Links for UTP20 Gene

GeneLoc Exon Structure for
UTP20
ECgene alternative splicing isoforms for
UTP20

Expression for UTP20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP20 Gene

Protein differential expression in normal tissues from HIPED for UTP20 Gene

This gene is overexpressed in Stomach (16.9), Blymphocyte (10.9), and Adrenal (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP20 Gene



Protein tissue co-expression partners for UTP20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP20 Gene:

UTP20

SOURCE GeneReport for Unigene cluster for UTP20 Gene:

Hs.295732

mRNA Expression by UniProt/SwissProt for UTP20 Gene:

O75691-UTP20_HUMAN
Tissue specificity: Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
genes like me logo Genes that share expression patterns with UTP20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP20 Gene

Orthologs for UTP20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP20 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia UTP20 33 34
  • 89.61 (n)
cow
(Bos Taurus)
Mammalia UTP20 33 34
  • 89.14 (n)
rat
(Rattus norvegicus)
Mammalia Utp20 33
  • 84.29 (n)
mouse
(Mus musculus)
Mammalia Utp20 33 16 34
  • 84.25 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP20 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP20 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP20 33 34
  • 69.14 (n)
lizard
(Anolis carolinensis)
Reptilia UTP20 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia utp20 33
  • 65.96 (n)
zebrafish
(Danio rerio)
Actinopterygii im:7159098 33
  • 60.89 (n)
UTP20 34
  • 57 (a)
OneToOne
wufb83c08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1547 33
fruit fly
(Drosophila melanogaster)
Insecta CG4554 33 34
  • 42.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005033 33
  • 40.84 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-184 33 34
  • 42.8 (n)
C56E6.9 34
  • 22 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17425g 33
  • 43.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL006W 33
  • 42.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP20 33 34 36
  • 42.3 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp20 33
  • 43.44 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02494 33
  • 41.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for UTP20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP20 Gene

ENSEMBL:
Gene Tree for UTP20 (if available)
TreeFam:
Gene Tree for UTP20 (if available)

Paralogs for UTP20 Gene

No data available for Paralogs for UTP20 Gene

Variants for UTP20 Gene

Sequence variations from dbSNP and Humsavar for UTP20 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs140657361 A breast cancer sample 101,352,104(+) A/T coding_sequence_variant, missense_variant
VAR_036275 A breast cancer sample p.Ile2452Phe
rs1000015666 -- 101,371,735(+) T/A/C intron_variant
rs1000017917 -- 101,299,766(+) G/C coding_sequence_variant, missense_variant
rs1000070312 -- 101,326,425(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UTP20 Gene

Variant ID Type Subtype PubMed ID
esv2152079 CNV deletion 18987734
esv2497077 CNV deletion 19546169
esv2663815 CNV deletion 23128226
esv2746278 CNV deletion 23290073
esv2746279 CNV deletion 23290073
esv3549687 CNV deletion 23714750
esv3630567 CNV loss 21293372
nsv470315 CNV gain 18288195
nsv510315 OTHER sequence alteration 20534489
nsv527122 CNV loss 19592680
nsv527505 CNV loss 19592680
nsv53174 CNV deletion 16902084

Variation tolerance for UTP20 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTP20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP20 Gene

Disorders for UTP20 Gene

Additional Disease Information for UTP20

No disorders were found for UTP20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP20 Gene

Publications for UTP20 Gene

  1. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing. (PMID: 17498821) Wang Y … Ke Y (Biochimica et biophysica acta 2007) 2 3 4 58
  2. Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis. (PMID: 9673349) Schwirzke M … Weidle UH (Anticancer research 1998) 2 3 4 58
  3. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell CJ … Demissie S (BMC medical genetics 2007) 3 44 58
  4. Mapping nucleolar localization sequences of 1A6/DRIM. (PMID: 16458307) Liu J … Ke Y (FEBS letters 2006) 3 4 58
  5. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential. (PMID: 16053918) Yang L … Ke Y (Biochemical and biophysical research communications 2005) 3 4 58

Products for UTP20 Gene

Sources for UTP20 Gene

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