The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this pro... See more...

Aliases for UTF1 Gene

Aliases for UTF1 Gene

  • Undifferentiated Embryonic Cell Transcription Factor 1 2 3 4 5
  • UTF1 5

External Ids for UTF1 Gene

Previous GeneCards Identifiers for UTF1 Gene

  • GC10P133958
  • GC10P134173
  • GC10P134959
  • GC10P134517
  • GC10P134932
  • GC10P135043
  • GC10P128590

Summaries for UTF1 Gene

Entrez Gene Summary for UTF1 Gene

  • The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

GeneCards Summary for UTF1 Gene

UTF1 (Undifferentiated Embryonic Cell Transcription Factor 1) is a Protein Coding gene. Diseases associated with UTF1 include Spermatocytoma and Germ Cell And Embryonal Cancer. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and HMG box domain binding. An important paralog of this gene is LOC100421372.

UniProtKB/Swiss-Prot Summary for UTF1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UTF1 Gene

Genomics for UTF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UTF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133230 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 250.7 +0.4 384 2 ZNF592 NFIC NONO NRF1 L3MBTL2 ZNF561 ZFP3 ZNF660 EZH2 CTBP1 UTF1 KNDC1 MN297018 VENTX
GH10J133224 Enhancer 0.9 Ensembl ENCODE 0.7 -4.5 -4516 1.8 IKZF1 ZNF592 TBP ZNF341 IRF2 EZH2 TAL1 PRDM10 RAD21 BHLHE40 HSALNG0081883 KNDC1 UTF1
GH10J133234 Promoter/Enhancer 1 FANTOM5 Ensembl 0.4 +5.8 5784 2 SPI1 MYC MAX EGR1 NRF1 CREM PHF20 GABPB1 EZH2 HSALNG0081884 VENTX MN297018 ADAM8 TUBGCP2 UTF1
GH10J133232 Enhancer 0.6 Ensembl ENCODE 0.7 +2.3 2308 1.4 POU5F1 NANOG GLIS2 EZH2 KNDC1 UTF1 MN297018 VENTX
GH10J133237 Enhancer 0.4 ENCODE 0.4 +7.3 7255 0.2 ZBTB7A KDM1A EZH2 HSALNG0081884 VENTX MN297018 UTF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UTF1

Top Transcription factor binding sites by QIAGEN in the UTF1 gene promoter:
  • AhR
  • Arnt

Genomic Locations for UTF1 Gene

Latest Assembly
chr10:133,230,217-133,231,558
(GRCh38/hg38)
Size:
1,342 bases
Orientation:
Plus strand

Previous Assembly
chr10:135,043,721-135,045,062
(GRCh37/hg19 by Entrez Gene)
Size:
1,342 bases
Orientation:
Plus strand

chr10:135,043,778-135,045,062
(GRCh37/hg19 by Ensembl)
Size:
1,285 bases
Orientation:
Plus strand

Genomic View for UTF1 Gene

Genes around UTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTF1 Gene

Proteins for UTF1 Gene

  • Protein details for UTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T230-UTF1_HUMAN
    Recommended name:
    Undifferentiated embryonic cell transcription factor 1
    Protein Accession:
    Q5T230
    Secondary Accessions:
    • O75833
    • Q6J1H3

    Protein attributes for UTF1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36439 Da
    Quaternary structure:
    • Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
    SequenceCaution:
    • Sequence=AAT38949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTF1 Gene

Post-translational modifications for UTF1 Gene

Other Protein References for UTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTF1 Gene

Domains & Families for UTF1 Gene

Gene Families for UTF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for UTF1 Gene

GenScript: Design optimal peptide antigens:
  • Undifferentiated embryonic cell transcription factor 1 (UTF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T230

UniProtKB/Swiss-Prot:

UTF1_HUMAN :
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
Domain:
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
genes like me logo Genes that share domains with UTF1: view

No data available for Protein Domains for UTF1 Gene

Function for UTF1 Gene

Molecular function for UTF1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional coactivator of ATF2.
GENATLAS Biochemistry:
undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell line,homolog,potentiating ATF-2 (activating transcription factor)-2 activity

Gene Ontology (GO) - Molecular Function for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS,IDA 9748258
GO:0005515 protein binding IPI 9748258
genes like me logo Genes that share ontologies with UTF1: view
genes like me logo Genes that share phenotypes with UTF1: view

Animal Models for UTF1 Gene

MGI Knock Outs for UTF1:
  • Utf1 Utf1<tm1Okud>

miRNA for UTF1 Gene

miRTarBase miRNAs that target UTF1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTF1 Gene

Localization for UTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTF1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
mitochondrion 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18281244
genes like me logo Genes that share ontologies with UTF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTF1 Gene

Pathways & Interactions for UTF1 Gene

genes like me logo Genes that share pathways with UTF1: view

Pathways by source for UTF1 Gene

2 Qiagen pathways for UTF1 Gene
  • Human Embryonic Stem Cell Pluripotency
  • Oct4 in Mammalian ESC Pluripotency
1 Cell Signaling Technology pathway for UTF1 Gene

Gene Ontology (GO) - Biological Process for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS 9748258
GO:0008584 male gonad development IEP 18281244
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 9748258
genes like me logo Genes that share ontologies with UTF1: view

No data available for SIGNOR curated interactions for UTF1 Gene

Drugs & Compounds for UTF1 Gene

No Compound Related Data Available

Transcripts for UTF1 Gene

mRNA/cDNA for UTF1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTF1

Alternative Splicing Database (ASD) splice patterns (SP) for UTF1 Gene

No ASD Table

Relevant External Links for UTF1 Gene

GeneLoc Exon Structure for
UTF1

Expression for UTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTF1 Gene

This gene is overexpressed in Testis (x38.2).

Protein differential expression in normal tissues from HIPED for UTF1 Gene

This gene is overexpressed in Testis (33.0), Adipocyte (21.8), and Fetal ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UTF1 Gene



Protein tissue co-expression partners for UTF1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UTF1

SOURCE GeneReport for Unigene cluster for UTF1 Gene:

Hs.458406
genes like me logo Genes that share expression patterns with UTF1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTF1 Gene

Orthologs for UTF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UTF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UTF1 29
  • 95.17 (n)
Rat
(Rattus norvegicus)
Mammalia Utf1 29
  • 70.63 (n)
Mouse
(Mus musculus)
Mammalia Utf1 29 16 30
  • 69.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UTF1 30
  • 68 (a)
OneToOne
Species where no ortholog for UTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for UTF1 Gene

ENSEMBL:
Gene Tree for UTF1 (if available)
TreeFam:
Gene Tree for UTF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UTF1: view image
Alliance of Genome Resources:
Additional Orthologs for UTF1

Paralogs for UTF1 Gene

Paralogs for UTF1 Gene

genes like me logo Genes that share paralogs with UTF1: view

Variants for UTF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UTF1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs11599284 -- p.Gly73Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UTF1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UTF1 Gene

Variant ID Type Subtype PubMed ID
dgv1474n54 CNV loss 21841781
dgv185n67 CNV gain 20364138
dgv2e196 CNV duplication 17116639
dgv558n106 CNV deletion 24896259
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3625030 CNV gain 21293372
esv3625031 CNV gain 21293372
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv470980 CNV loss 18288195
nsv528260 CNV loss 19592680
nsv552574 CNV gain 21841781
nsv820950 CNV deletion 20802225
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv8750 CNV gain+loss 18304495
nsv952705 CNV deletion 24416366

Variation tolerance for UTF1 Gene

Gene Damage Index Score: 5.02; 68.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTF1 Gene

Human Gene Mutation Database (HGMD)
UTF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTF1
Leiden Open Variation Database (LOVD)
UTF1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTF1 Gene

Disorders for UTF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UTF1 Gene - From: COP

Disorder Aliases PubMed IDs
spermatocytoma
  • spermatocytic seminoma
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards
Search UTF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTF1

genes like me logo Genes that share disorders with UTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTF1 Gene

Publications for UTF1 Gene

  1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PMID: 9748258) Fukushima A … Muramatsu M (The Journal of biological chemistry 1998) 2 3 4
  2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PMID: 18281244) Kristensen DM … Leffers H (Human reproduction (Oxford, England) 2008) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. (PMID: 30862715) Liu C … Buckhaults PJ (Cancer research 2019) 3

Products for UTF1 Gene

Sources for UTF1 Gene