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Aliases for UTF1 Gene

Aliases for UTF1 Gene

  • Undifferentiated Embryonic Cell Transcription Factor 1 2 3 5

External Ids for UTF1 Gene

Previous GeneCards Identifiers for UTF1 Gene

  • GC10P133958
  • GC10P134173
  • GC10P134959
  • GC10P134517
  • GC10P134932
  • GC10P135043
  • GC10P128590

Summaries for UTF1 Gene

Entrez Gene Summary for UTF1 Gene

  • The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

GeneCards Summary for UTF1 Gene

UTF1 (Undifferentiated Embryonic Cell Transcription Factor 1) is a Protein Coding gene. Diseases associated with UTF1 include Opportunistic Bacterial Infectious Disease and Nocardiosis. Among its related pathways are Wnt / Hedgehog / Notch and Oct4 in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and HMG box domain binding.

UniProtKB/Swiss-Prot for UTF1 Gene

  • Acts as a transcriptional coactivator of ATF2.

Additional gene information for UTF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTF1 Gene

Genomics for UTF1 Gene

GeneHancer (GH) Regulatory Elements for UTF1 Gene

Promoters and enhancers for UTF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I133230 Promoter 0.7 EPDnew 550.8 -0.1 -76 0.1 POLR2A EZH2 UTF1 LOC105378573
GH10I133231 Enhancer 0.6 ENCODE 550.8 +0.3 338 0.1 MXI1 L3MBTL2 SUZ12 NRF1 ZNF592 ZFHX2 NFIC CTBP1 ZBTB26 EZH2 UTF1 VENTX
GH10I133232 Enhancer 0.4 ENCODE 550.8 +2.0 1958 0.8 GLIS2 POU5F1 EZH2 UTF1 KNDC1 VENTX
GH10I133234 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 0.4 +6.6 6552 4 RING1 SUZ12 MAX ZBTB7A SP1 EGR1 PHF20 GABPB1 VEZF1 CTBP2 VENTX TUBGCP2 ADAM8 UTF1
GH10I133224 Enhancer 0.7 ENCODE 0.8 -5.0 -4980 0.9 IRF2 PKNOX1 ZBTB40 ZFHX2 GLIS2 FOXK2 POLR2A EGR1 VEZF1 PRDM10 KNDC1 UTF1 LOC105378573
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UTF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UTF1 gene promoter:

Genomic Locations for UTF1 Gene

Genomic Locations for UTF1 Gene
chr10:133,230,274-133,231,558
(GRCh38/hg38)
Size:
1,285 bases
Orientation:
Plus strand
chr10:135,043,778-135,045,062
(GRCh37/hg19)

Genomic View for UTF1 Gene

Genes around UTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTF1 Gene

Proteins for UTF1 Gene

  • Protein details for UTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T230-UTF1_HUMAN
    Recommended name:
    Undifferentiated embryonic cell transcription factor 1
    Protein Accession:
    Q5T230
    Secondary Accessions:
    • O75833
    • Q6J1H3

    Protein attributes for UTF1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36439 Da
    Quaternary structure:
    • Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
    SequenceCaution:
    • Sequence=AAT38949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTF1 Gene

Post-translational modifications for UTF1 Gene

Other Protein References for UTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTF1 Gene

Domains & Families for UTF1 Gene

Gene Families for UTF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for UTF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T230

UniProtKB/Swiss-Prot:

UTF1_HUMAN :
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
Domain:
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
genes like me logo Genes that share domains with UTF1: view

Function for UTF1 Gene

Molecular function for UTF1 Gene

GENATLAS Biochemistry:
undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell line,homolog,potentiating ATF-2 (activating transcription factor)-2 activity
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional coactivator of ATF2.

Gene Ontology (GO) - Molecular Function for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 9748258
GO:0005515 protein binding IPI 9748258
GO:0071837 HMG box domain binding IEA --
genes like me logo Genes that share ontologies with UTF1: view
genes like me logo Genes that share phenotypes with UTF1: view

Animal Models for UTF1 Gene

MGI Knock Outs for UTF1:

miRNA for UTF1 Gene

miRTarBase miRNAs that target UTF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTF1 Gene

Localization for UTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTF1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18281244
genes like me logo Genes that share ontologies with UTF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTF1 Gene

Pathways & Interactions for UTF1 Gene

genes like me logo Genes that share pathways with UTF1: view

Pathways by source for UTF1 Gene

Gene Ontology (GO) - Biological Process for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9748258
GO:0008584 male gonad development IEP 18281244
GO:0045944 positive regulation of transcription by RNA polymerase II IDA,IEA 9748258
genes like me logo Genes that share ontologies with UTF1: view

No data available for SIGNOR curated interactions for UTF1 Gene

Drugs & Compounds for UTF1 Gene

No Compound Related Data Available

Transcripts for UTF1 Gene

mRNA/cDNA for UTF1 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTF1 Gene

No ASD Table

Relevant External Links for UTF1 Gene

GeneLoc Exon Structure for
UTF1
ECgene alternative splicing isoforms for
UTF1

Expression for UTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTF1 Gene

This gene is overexpressed in Testis (x38.2).

Protein differential expression in normal tissues from HIPED for UTF1 Gene

This gene is overexpressed in Testis (33.0), Adipocyte (21.8), and Fetal ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTF1 Gene



Protein tissue co-expression partners for UTF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UTF1 Gene:

UTF1

SOURCE GeneReport for Unigene cluster for UTF1 Gene:

Hs.458406
genes like me logo Genes that share expression patterns with UTF1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTF1 Gene

Orthologs for UTF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTF1 33
  • 95.17 (n)
rat
(Rattus norvegicus)
Mammalia Utf1 33
  • 70.63 (n)
mouse
(Mus musculus)
Mammalia Utf1 33 16 34
  • 69.45 (n)
cow
(Bos Taurus)
Mammalia UTF1 34
  • 68 (a)
OneToOne
Species where no ortholog for UTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTF1 Gene

ENSEMBL:
Gene Tree for UTF1 (if available)
TreeFam:
Gene Tree for UTF1 (if available)

Paralogs for UTF1 Gene

No data available for Paralogs for UTF1 Gene

Variants for UTF1 Gene

Sequence variations from dbSNP and Humsavar for UTF1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000832452 -- 133,229,421(+) G/A upstream_transcript_variant
rs1002005357 -- 133,229,056(+) C/G upstream_transcript_variant
rs1002458680 -- 133,230,371(+) C/T coding_sequence_variant, missense_variant
rs1002622890 -- 133,230,678(+) C/T coding_sequence_variant, synonymous_variant
rs1004016861 -- 133,231,949(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UTF1 Gene

Variant ID Type Subtype PubMed ID
dgv1474n54 CNV loss 21841781
dgv185n67 CNV gain 20364138
dgv2e196 CNV duplication 17116639
dgv558n106 CNV deletion 24896259
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3625030 CNV gain 21293372
esv3625031 CNV gain 21293372
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv470980 CNV loss 18288195
nsv528260 CNV loss 19592680
nsv552574 CNV gain 21841781
nsv820950 CNV deletion 20802225
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv8750 CNV gain+loss 18304495
nsv952705 CNV deletion 24416366

Variation tolerance for UTF1 Gene

Gene Damage Index Score: 5.02; 68.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTF1 Gene

Human Gene Mutation Database (HGMD)
UTF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTF1 Gene

Disorders for UTF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UTF1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
opportunistic bacterial infectious disease
nocardiosis
  • nocardia infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search UTF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTF1

genes like me logo Genes that share disorders with UTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTF1 Gene

Publications for UTF1 Gene

  1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PMID: 9748258) Fukushima A … Muramatsu M (The Journal of biological chemistry 1998) 2 3 4 58
  2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PMID: 18281244) Kristensen DM … Leffers H (Human reproduction (Oxford, England) 2008) 2 3 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas. (PMID: 24614704) Pantazis G … Schittenhelm J (Pathology 2014) 3 58

Products for UTF1 Gene

Sources for UTF1 Gene

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