External Ids for UTF1 Gene
Previous GeneCards Identifiers for UTF1 Gene
The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]
GeneCards Summary for UTF1 Gene
UTF1 (Undifferentiated Embryonic Cell Transcription Factor 1) is a Protein Coding gene. Diseases associated with UTF1 include Spermatocytoma and Germ Cell And Embryonal Cancer. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and HMG box domain binding. An important paralog of this gene is LOC100421372.
UniProtKB/Swiss-Prot Summary for UTF1 Gene
Acts as a transcriptional coactivator of ATF2.