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Aliases for UST Gene

Aliases for UST Gene

  • Uronyl 2-Sulfotransferase 2 3 5
  • Dermatan/Chondroitin Sulfate 2-Sulfotransferase 3
  • EC 2.8.2.- 4
  • DS2ST 4
  • 2OST 3

External Ids for UST Gene

Previous GeneCards Identifiers for UST Gene

  • GC06P148915
  • GC06P149049
  • GC06P149110
  • GC06P146637

Summaries for UST Gene

Entrez Gene Summary for UST Gene

  • Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UST Gene

UST (Uronyl 2-Sulfotransferase) is a Protein Coding gene. Diseases associated with UST include Liver Inflammatory Pseudotumor and Female Stress Incontinence. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is HS2ST1.

UniProtKB/Swiss-Prot for UST Gene

  • Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.

Additional gene information for UST Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UST Gene

Genomics for UST Gene

GeneHancer (GH) Regulatory Elements for UST Gene

Promoters and enhancers for UST Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I148745 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555 +0.5 461 3.2 FOXA2 SIN3A FEZF1 ZNF2 ETS1 ZNF121 GLIS2 ZNF143 FOS SP3 UST LATS1 KATNA1 PPIL4 GC06P148933
GH06I148972 Enhancer 1 Ensembl ENCODE 7 +225.6 225645 1 PKNOX1 KLF17 SIN3A FEZF1 ZNF2 ETS1 TCF12 ZSCAN5C SCRT2 FOS PPIL4 RNU7-3P UST UST-AS1 LOC105378047
GH06I148979 Enhancer 0.9 ENCODE 7.7 +232.6 232628 1.2 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 ZNF48 ZSCAN9 RARA SLC30A9 UST UST-AS1 LOC105378047
GH06I148967 Enhancer 0.9 FANTOM5 Ensembl ENCODE 6.8 +222.1 222101 3.8 NFIA MZF1 FOS ATF2 ZIC2 MAFK RNU7-3P PPIL4 UST UST-AS1 LOC105378047
GH06I148519 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.2 -223.6 -223604 7.1 PKNOX1 JUN EBF1 BATF IRF4 FOSL1 NFATC1 ATF7 TRIM24 ETV6 UST GC06M148489 GC06M148568 SASH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UST on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UST gene promoter:

Genomic Locations for UST Gene

Genomic Locations for UST Gene
chr6:148,746,962-149,076,990
(GRCh38/hg38)
Size:
330,029 bases
Orientation:
Plus strand
chr6:149,068,271-149,398,126
(GRCh37/hg19)

Genomic View for UST Gene

Genes around UST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UST Gene

Proteins for UST Gene

  • Protein details for UST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C2-UST_HUMAN
    Recommended name:
    Uronyl 2-sulfotransferase
    Protein Accession:
    Q9Y2C2
    Secondary Accessions:
    • B2RCX6

    Protein attributes for UST Gene

    Size:
    406 amino acids
    Molecular mass:
    47673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UST Gene

Post-translational modifications for UST Gene

  • Ubiquitination at isoforms=32
  • Glycosylation at isoforms=84, isoforms=140, posLast=155155, isoforms=173, and posLast=319319
  • Modification sites at PhosphoSitePlus

Other Protein References for UST Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UST Gene

Domains & Families for UST Gene

Gene Families for UST Gene

Protein Domains for UST Gene

Suggested Antigen Peptide Sequences for UST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2C2

UniProtKB/Swiss-Prot:

UST_HUMAN :
  • Belongs to the sulfotransferase 3 family.
Family:
  • Belongs to the sulfotransferase 3 family.
genes like me logo Genes that share domains with UST: view

Function for UST Gene

Molecular function for UST Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.

Enzyme Numbers (IUBMB) for UST Gene

Phenotypes From GWAS Catalog for UST Gene

Gene Ontology (GO) - Molecular Function for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UST: view
genes like me logo Genes that share phenotypes with UST: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UST Gene

Localization for UST Gene

Subcellular locations from UniProtKB/Swiss-Prot for UST Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UST gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
mitochondrion 3
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with UST: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UST Gene

Pathways & Interactions for UST Gene

genes like me logo Genes that share pathways with UST: view

Gene Ontology (GO) - Biological Process for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006477 protein sulfation TAS 10187838
GO:0030010 establishment of cell polarity IEA --
GO:0030208 dermatan sulfate biosynthetic process TAS --
GO:0050770 regulation of axonogenesis IEA --
genes like me logo Genes that share ontologies with UST: view

No data available for SIGNOR curated interactions for UST Gene

Drugs & Compounds for UST Gene

(1) Drugs for UST Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nortriptyline Approved Pharma Antagonist, Pore Blocker 50

(1) Additional Compounds for UST Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
genes like me logo Genes that share compounds with UST: view

Transcripts for UST Gene

Unigene Clusters for UST Gene

Uronyl-2-sulfotransferase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UST Gene

No ASD Table

Relevant External Links for UST Gene

GeneLoc Exon Structure for
UST
ECgene alternative splicing isoforms for
UST

Expression for UST Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UST Gene

This gene is overexpressed in Pancreas (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UST Gene



Protein tissue co-expression partners for UST Gene

NURSA nuclear receptor signaling pathways regulating expression of UST Gene:

UST

SOURCE GeneReport for Unigene cluster for UST Gene:

Hs.657370

mRNA Expression by UniProt/SwissProt for UST Gene:

Q9Y2C2-UST_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for UST Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with UST: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UST Gene

Orthologs for UST Gene

This gene was present in the common ancestor of animals.

Orthologs for UST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UST 33 34
  • 97.07 (n)
dog
(Canis familiaris)
Mammalia UST 34 33
  • 94.07 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UST 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UST 33
  • 92.83 (n)
mouse
(Mus musculus)
Mammalia Ust 33 16 34
  • 90.29 (n)
rat
(Rattus norvegicus)
Mammalia Ust 33
  • 90.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves UST 33 34
  • 84.62 (n)
lizard
(Anolis carolinensis)
Reptilia UST 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ust 33
  • 75.55 (n)
zebrafish
(Danio rerio)
Actinopterygii ust 33 34
  • 70.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta pip 34
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
Species where no ortholog for UST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UST Gene

ENSEMBL:
Gene Tree for UST (if available)
TreeFam:
Gene Tree for UST (if available)

Paralogs for UST Gene

Paralogs for UST Gene

(1) SIMAP similar genes for UST Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UST: view

Variants for UST Gene

Sequence variations from dbSNP and Humsavar for UST Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000005208 -- 148,818,007(+) C/T intron_variant
rs1000015550 -- 148,744,192(+) T/A upstream_transcript_variant
rs1000033127 -- 149,046,740(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000056751 -- 148,774,971(+) T/C intron_variant
rs1000061724 -- 148,863,317(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UST Gene

Variant ID Type Subtype PubMed ID
dgv1066n67 CNV loss 20364138
dgv1838e212 CNV loss 25503493
esv2067920 CNV deletion 18987734
esv2430067 CNV deletion 19546169
esv2666090 CNV deletion 23128226
esv2668797 CNV deletion 23128226
esv2672117 CNV deletion 23128226
esv2673783 CNV deletion 23128226
esv2675997 CNV deletion 23128226
esv27051 CNV loss 19812545
esv2732848 CNV deletion 23290073
esv2732849 CNV deletion 23290073
esv2732850 CNV deletion 23290073
esv2732852 CNV deletion 23290073
esv2732853 CNV deletion 23290073
esv27730 CNV loss 19812545
esv3302933 CNV tandem duplication 20981092
esv3305323 CNV mobile element insertion 20981092
esv3326645 CNV insertion 20981092
esv3540613 CNV deletion 23714750
esv3611197 CNV loss 21293372
esv3611200 CNV loss 21293372
esv3611201 CNV loss 21293372
esv3611202 CNV loss 21293372
esv992551 CNV insertion 20482838
nsv1073594 CNV deletion 25765185
nsv1109820 CNV deletion 24896259
nsv464074 CNV loss 19166990
nsv464075 CNV loss 19166990
nsv470865 CNV loss 18288195
nsv604844 CNV loss 21841781
nsv604845 CNV loss 21841781
nsv830842 CNV gain 17160897
nsv949865 CNV deletion 24416366

Variation tolerance for UST Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UST Gene

Human Gene Mutation Database (HGMD)
UST
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UST

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UST Gene

Disorders for UST Gene

MalaCards: The human disease database

(4) MalaCards diseases for UST Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
liver inflammatory pseudotumor
  • inflammatory pseudotumor of the liver
female stress incontinence
  • female urinary stress incontinence
phobia, specific
  • phobia, simple
spherocytosis, type 2
  • sph2
- elite association - COSMIC cancer census association via MalaCards
Search UST in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UST

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UST Gene

Publications for UST Gene

  1. Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PMID: 10187838) Kobayashi M … Rosenberg RD (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R … McGuffin P (The American journal of psychiatry 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for UST Gene

Sources for UST Gene

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