Aliases for USP9Y Gene
External Ids for USP9Y Gene
Previous GeneCards Identifiers for USP9Y Gene
This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009]
GeneCards Summary for USP9Y Gene
USP9Y (Ubiquitin Specific Peptidase 9 Y-Linked) is a Protein Coding gene. Diseases associated with USP9Y include Spermatogenic Failure, Y-Linked, 2 and Partial Deletion Of Y. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP9X.
UniProtKB/Swiss-Prot Summary for USP9Y Gene
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).