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Aliases for USP51 Gene

Aliases for USP51 Gene

  • Ubiquitin Specific Peptidase 51 2 3 5
  • Ubiquitin-Specific-Processing Protease 51 4
  • Ubiquitin Specific Protease 51 2
  • Deubiquitinating Enzyme 51 4
  • Ubiquitin Thioesterase 51 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56

External Ids for USP51 Gene

Previous GeneCards Identifiers for USP51 Gene

  • GC0XU900509
  • GC0XM054480
  • GC0XM055396
  • GC0XM055529
  • GC0XM052562

Summaries for USP51 Gene

GeneCards Summary for USP51 Gene

USP51 (Ubiquitin Specific Peptidase 51) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP22.

UniProtKB/Swiss-Prot for USP51 Gene

  • Specifically deubiquitinates Lys-14 (H2AK13Ub) and Lys-16(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for Lys-27 or Lys-63-linked di-ubiquitin (PubMed:27083998).

Gene Wiki entry for USP51 Gene

Additional gene information for USP51 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP51 Gene

Genomics for USP51 Gene

GeneHancer (GH) Regulatory Elements for USP51 Gene

Promoters and enhancers for USP51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI055488 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.5 541 4.1 ZNF76 SIN3A YY1 ZNF335 EGR1 SCRT2 CREM SP3 SMAD5 ZBTB11 LOC101928692 USP51 MAGEH1 KLF8
GH0XI055487 Enhancer 0.3 ENCODE 0.8 +2.8 2784 0.1 RFX1 LOC101928692 USP51 PAGE3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP51 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP51 gene promoter:

Genomic Locations for USP51 Gene

Genomic Locations for USP51 Gene
chrX:55,484,616-55,489,868
(GRCh38/hg38)
Size:
5,253 bases
Orientation:
Minus strand
chrX:55,511,049-55,515,635
(GRCh37/hg19)

Genomic View for USP51 Gene

Genes around USP51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP51 Gene

Proteins for USP51 Gene

  • Protein details for USP51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EK9-UBP51_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 51
    Protein Accession:
    Q70EK9
    Secondary Accessions:
    • Q8IWJ8

    Protein attributes for USP51 Gene

    Size:
    711 amino acids
    Molecular mass:
    79756 Da
    Quaternary structure:
    • Interacts with H2A (PubMed:27083998).
    SequenceCaution:
    • Sequence=AAH35907.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for USP51 Gene

Selected DME Specific Peptides for USP51 Gene

Q70EK9:
  • SYQESTKQ
  • RKRKAKSC
  • TCFMNCIVQAL
  • GNTCFMN
  • PHIPYKLLHL
  • CNCIIDQIFTG
  • CDDAIITKA
  • FTRPEHLGSSAKIKC
  • QQDAHEF
  • CVFFGCF
  • VSTTIDP
  • NLGNTCF

Post-translational modifications for USP51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP51 Gene

Domains & Families for USP51 Gene

Gene Families for USP51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for USP51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70EK9

UniProtKB/Swiss-Prot:

UBP51_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP51: view

Function for USP51 Gene

Molecular function for USP51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Specifically deubiquitinates Lys-14 (H2AK13Ub) and Lys-16(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for Lys-27 or Lys-63-linked di-ubiquitin (PubMed:27083998).

Enzyme Numbers (IUBMB) for USP51 Gene

Gene Ontology (GO) - Molecular Function for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 27083998
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with USP51: view
genes like me logo Genes that share phenotypes with USP51: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP51 Gene

Localization for USP51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP51 Gene

Chromosome. Note=Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair. {ECO:0000269 PubMed:27083998}.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with USP51: view

No data available for Subcellular locations from COMPARTMENTS for USP51 Gene

Pathways & Interactions for USP51 Gene

genes like me logo Genes that share pathways with USP51: view

Pathways by source for USP51 Gene

1 Qiagen pathway for USP51 Gene

Gene Ontology (GO) - Biological Process for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0010564 regulation of cell cycle process IMP 27083998
genes like me logo Genes that share ontologies with USP51: view

No data available for SIGNOR curated interactions for USP51 Gene

Drugs & Compounds for USP51 Gene

(1) Drugs for USP51 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP51: view

Transcripts for USP51 Gene

mRNA/cDNA for USP51 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP51 Gene

Ubiquitin specific peptidase 51:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP51 Gene

No ASD Table

Relevant External Links for USP51 Gene

GeneLoc Exon Structure for
USP51
ECgene alternative splicing isoforms for
USP51

Expression for USP51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP51 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP51 Gene:

USP51

SOURCE GeneReport for Unigene cluster for USP51 Gene:

Hs.40061

mRNA Expression by UniProt/SwissProt for USP51 Gene:

Q70EK9-UBP51_HUMAN
Tissue specificity: Expressed in prostate, brain, lung, aorta and kidney.
genes like me logo Genes that share expression patterns with USP51: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP51 Gene

Orthologs for USP51 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP51 33 34
  • 99.77 (n)
rat
(Rattus norvegicus)
Mammalia Usp51 33
  • 82.18 (n)
mouse
(Mus musculus)
Mammalia Usp51 33 16 34
  • 81.85 (n)
oppossum
(Monodelphis domestica)
Mammalia USP51 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii usp22 34
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta not 34
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1941 34
  • 50 (a)
OneToMany
Species where no ortholog for USP51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP51 Gene

ENSEMBL:
Gene Tree for USP51 (if available)
TreeFam:
Gene Tree for USP51 (if available)

Paralogs for USP51 Gene

Variants for USP51 Gene

Sequence variations from dbSNP and Humsavar for USP51 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000090055 -- 55,489,369(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000902230 -- 55,485,031(-) G/A 3_prime_UTR_variant
rs1001083686 -- 55,486,166(-) G/T 3_prime_UTR_variant
rs1001729477 -- 55,490,714(-) A/C upstream_transcript_variant
rs1002133142 -- 55,485,271(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for USP51 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
nsv435891 CNV deletion 17901297
nsv469510 CNV gain 16826518
nsv499493 OTHER inversion 21111241
nsv524155 CNV gain 19592680
nsv7448 OTHER inversion 18451855

Variation tolerance for USP51 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP51

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP51 Gene

Disorders for USP51 Gene

Additional Disease Information for USP51

No disorders were found for USP51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP51 Gene

Publications for USP51 Gene

  1. USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. (PMID: 27083998) Wang Z … Zhang Z (Genes & development 2016) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 58
  4. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente XS … López-Otín C (Genome research 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for USP51 Gene

Sources for USP51 Gene

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