Aliases for USP49 Gene
External Ids for USP49 Gene
Previous GeneCards Identifiers for USP49 Gene
GeneCards Summary for USP49 Gene
USP49 (Ubiquitin Specific Peptidase 49) is a Protein Coding gene. Among its related pathways are Deubiquitination and Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include histone binding and cysteine-type peptidase activity. An important paralog of this gene is USP44.
UniProtKB/Swiss-Prot Summary for USP49 Gene
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.