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Aliases for USP43 Gene

Aliases for USP43 Gene

  • Ubiquitin Specific Peptidase 43 2 3 5
  • Ubiquitin-Specific-Processing Protease 43 4
  • Ubiquitin Specific Protease 43 2
  • Deubiquitinating Enzyme 43 4
  • Ubiquitin Thioesterase 43 4
  • EC 4
  • EC 56

External Ids for USP43 Gene

Previous GeneCards Identifiers for USP43 Gene

  • GC17P009491
  • GC17P009749
  • GC17P009489
  • GC17P009548

Summaries for USP43 Gene

GeneCards Summary for USP43 Gene

USP43 (Ubiquitin Specific Peptidase 43) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP31.

UniProtKB/Swiss-Prot for USP43 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Additional gene information for USP43 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP43 Gene

Genomics for USP43 Gene

GeneHancer (GH) Regulatory Elements for USP43 Gene

Promoters and enhancers for USP43 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I009643 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +3.3 3274 5.9 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000262296 ENSG00000265349 USP43 STX8 CFAP52
GH17I009684 Enhancer 0.7 ENCODE 23.8 +41.7 41662 1.2 SOX13 FOXA2 CEBPG RARA TEAD3 GATAD2A SOX5 TEAD1 NFIA FOXA3 USP43 GC17P009688 ENSG00000262296
GH17I009670 Enhancer 0.7 ENCODE 17.8 +28.8 28769 2.6 NCOA3 PKNOX1 NEUROD1 CEBPB DPF2 CEBPG FOXA1 SREBF1 CTBP1 GATA3 USP43 GC17P009688 ENSG00000262296
GH17I009565 Enhancer 0.9 ENCODE 10.5 -77.4 -77354 1 ZNF133 INSM2 FEZF1 ZNF2 ZNF335 ZNF213 ZNF366 ZSCAN5C KLF7 ZNF391 ENSG00000271851 USP43 STX8
GH17I009761 Enhancer 0.8 dbSUPER 10.2 +122.5 122465 8.1 CTCF PKNOX1 MXI1 JUN MAX BRCA1 RAD21 RFX5 ZNF664 POLR2A ENSG00000282882 ENSG00000261433 DHRS7C MAGOH2P USP43 ADPRM GC17M009779
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP43 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP43 gene promoter:

Genomic Locations for USP43 Gene

Genomic Locations for USP43 Gene
86,199 bases
Plus strand

Genomic View for USP43 Gene

Genes around USP43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP43 Gene

Proteins for USP43 Gene

  • Protein details for USP43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 43
    Protein Accession:
    Secondary Accessions:
    • A6NDT9
    • B7ZLT9
    • B7ZVX5
    • Q8N2C5
    • Q96DQ6

    Protein attributes for USP43 Gene

    1123 amino acids
    Molecular mass:
    122809 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70869.1; Type=Frameshift; Positions=619; Evidence={ECO:0000305};

    Alternative splice isoforms for USP43 Gene


neXtProt entry for USP43 Gene

Selected DME Specific Peptides for USP43 Gene


Post-translational modifications for USP43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for USP43 Gene

Gene Families for USP43 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP43 Gene

Suggested Antigen Peptide Sequences for USP43 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP43: view

Function for USP43 Gene

Molecular function for USP43 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP43 Gene

Gene Ontology (GO) - Molecular Function for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019785 ISG15-specific protease activity TAS --
genes like me logo Genes that share ontologies with USP43: view
genes like me logo Genes that share phenotypes with USP43: view

Animal Model Products

miRNA for USP43 Gene

miRTarBase miRNAs that target USP43

Clone Products

  • Addgene plasmids for USP43

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP43 Gene

Localization for USP43 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP43 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with USP43: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for USP43 Gene

Pathways & Interactions for USP43 Gene

genes like me logo Genes that share pathways with USP43: view

Gene Ontology (GO) - Biological Process for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,IBA --
GO:0019985 translesion synthesis TAS --
genes like me logo Genes that share ontologies with USP43: view

No data available for SIGNOR curated interactions for USP43 Gene

Drugs & Compounds for USP43 Gene

No Compound Related Data Available

Transcripts for USP43 Gene

Unigene Clusters for USP43 Gene

Ubiquitin specific peptidase 43:
Representative Sequences:

Clone Products

  • Addgene plasmids for USP43

Alternative Splicing Database (ASD) splice patterns (SP) for USP43 Gene

No ASD Table

Relevant External Links for USP43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP43 Gene

Protein differential expression in normal tissues from HIPED for USP43 Gene

This gene is overexpressed in Placenta (35.9) and Bone (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP43 Gene

Protein tissue co-expression partners for USP43 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP43 Gene:


SOURCE GeneReport for Unigene cluster for USP43 Gene:


mRNA Expression by UniProt/SwissProt for USP43 Gene:

Tissue specificity: Expressed in brain, aorta and lung at low levels.

Evidence on tissue expression from TISSUES for USP43 Gene

  • Nervous system(4.1)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with USP43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP43 Gene

Orthologs for USP43 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP43 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP43 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia USP43 33 34
  • 83.07 (n)
(Mus musculus)
Mammalia Usp43 33 16 34
  • 82.61 (n)
(Bos Taurus)
Mammalia USP43 33 34
  • 82.29 (n)
(Rattus norvegicus)
Mammalia Usp43 33
  • 81.88 (n)
(Monodelphis domestica)
Mammalia USP43 34
  • 63 (a)
(Gallus gallus)
Aves USP43 34
  • 64 (a)
(Anolis carolinensis)
Reptilia USP43 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp43 33
  • 60.77 (n)
(Danio rerio)
Actinopterygii LOC100149276 33
  • 63.18 (n)
usp43a 34
  • 46 (a)
usp43b 34
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for USP43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP43 Gene

Gene Tree for USP43 (if available)
Gene Tree for USP43 (if available)

Paralogs for USP43 Gene

Paralogs for USP43 Gene

(1) SIMAP similar genes for USP43 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with USP43: view

Variants for USP43 Gene

Sequence variations from dbSNP and Humsavar for USP43 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000009229 -- 9,724,342(+) G/A intron_variant
rs1000027648 -- 9,717,118(+) C/T intron_variant
rs1000041531 -- 9,704,363(+) T/A intron_variant
rs1000060828 -- 9,698,361(+) T/A intron_variant
rs1000061599 -- 9,724,507(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USP43 Gene

Variant ID Type Subtype PubMed ID
esv3639920 CNV loss 21293372
nsv1123094 CNV deletion 24896259
nsv510697 CNV deletion 20534489
nsv7289 OTHER inversion 18451855
nsv833357 CNV loss 17160897
nsv833358 CNV gain 17160897

Variation tolerance for USP43 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP43 Gene

Disorders for USP43 Gene

Additional Disease Information for USP43

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for USP43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP43 Gene

Publications for USP43 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 58
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for USP43 Gene

  • Addgene plasmids for USP43

Sources for USP43 Gene

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