Aliases for USP41 Gene

Aliases for USP41 Gene

  • Ubiquitin Specific Peptidase 41 2 3 5
  • Putative Ubiquitin Carboxyl-Terminal Hydrolase 41 3 4
  • Ubiquitin-Specific-Processing Protease 41 3 4
  • Deubiquitinating Enzyme 41 3 4
  • Ubiquitin Thioesterase 41 3 4
  • Ubiquitin Specific Proteinase 41 3
  • Ubiquitin Specific Protease 41 2
  • Ubiquitin Thiolesterase 41 3
  • EC 4
  • EC 51
  • USP41 5

External Ids for USP41 Gene

Previous GeneCards Identifiers for USP41 Gene

  • GC00U909401
  • GC22U900095
  • GC22M018726
  • GC22M019022
  • GC22M020704
  • GC22M003968

Summaries for USP41 Gene

GeneCards Summary for USP41 Gene

USP41 (Ubiquitin Specific Peptidase 41) is a Protein Coding gene. Diseases associated with USP41 include Hypertrichosis Universalis Congenita, Ambras Type. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP18.

UniProtKB/Swiss-Prot Summary for USP41 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Additional gene information for USP41 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP41 Gene

Genomics for USP41 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP41 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J020462 Promoter/Enhancer 0.9 Ensembl ENCODE 11.4 -73.3 -73271 2.8 PRDM10 PHF21A ZNF740 TARDBP USF2 RUNX3 KDM4B POLR2A YBX1 SPI1 lnc-SCARF2-3 MED15 SCARF2 RNU6-225P KLHL22 ZNF74 USP41 ENSG00000236003 LZTR1 lnc-SCARF2-2
GH22J020319 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +70.4 70444 3 RNF2 SP1 HNRNPL PRDM10 IKZF1 BACH1 TARDBP LARP7 MTA2 PHF21A DGCR6L ENSG00000273139 ENSG00000273343 DGCR8 LZTR1 THAP7-AS1 TRMT2A RANBP1 ENSG00000215493 MN297903
GH22J020386 Enhancer 0.5 Ensembl 0.7 +4.2 4157 1.2 GTF2A2 CEBPG ATF4 ZNF507 ATF2 ZNF354B DGCR8 THAP7 THAP7-AS1 LZTR1 TRMT2A ENSG00000215493 ZDHHC8 ZNF74 USP41 piR-43105-420
GH22J020364 Promoter 0.6 Ensembl 0.3 +25.8 25757 0.4 CEBPG CEBPB ZNF507 DGCR8 THAP7 THAP7-AS1 piR-49204-006 piR-43105-420 USP41 DGCR6L
GH22J020380 Enhancer 0.4 Ensembl 0.4 +10.0 10018 0.5 SCRT2 SCRT1 MEIS2 SCARF2 piR-43105-420 USP41 DGCR6L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP41 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the USP41 gene promoter:
  • C/EBPalpha
  • COMP1
  • Roaz
  • Spz1
  • YY1

Genomic Locations for USP41 Gene

Genomic Locations for USP41 Gene
40,181 bases
Minus strand
40,181 bases
Minus strand

Genomic View for USP41 Gene

Genes around USP41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP41 Gene

Proteins for USP41 Gene

  • Protein details for USP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 41
    Protein Accession:
    Secondary Accessions:
    • A8MXD0
    • Q70BM7

    Protein attributes for USP41 Gene

    358 amino acids
    Molecular mass:
    41394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP41 Gene

Selected DME Specific Peptides for USP41 Gene


Post-translational modifications for USP41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP41 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP41 Gene

Gene Families for USP41 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP41 Gene

  • Ubiquitin thiolesterase, family 2

Suggested Antigen Peptide Sequences for USP41 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-specific-processing protease 41 (UBP41_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP41: view

Function for USP41 Gene

Molecular function for USP41 Gene

UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=;.

Enzyme Numbers (IUBMB) for USP41 Gene

Gene Ontology (GO) - Molecular Function for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA 21873635
GO:0005515 protein binding IPI 19615732
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP41: view
genes like me logo Genes that share phenotypes with USP41: view

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP41 Gene

Localization for USP41 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP41 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with USP41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for USP41 Gene

Pathways & Interactions for USP41 Gene

genes like me logo Genes that share pathways with USP41: view

Pathways by source for USP41 Gene

1 Qiagen pathway for USP41 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis

Gene Ontology (GO) - Biological Process for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IBA 21873635
genes like me logo Genes that share ontologies with USP41: view

No data available for SIGNOR curated interactions for USP41 Gene

Drugs & Compounds for USP41 Gene

No Compound Related Data Available

Transcripts for USP41 Gene

mRNA/cDNA for USP41 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP41 Gene

No ASD Table

Relevant External Links for USP41 Gene

GeneLoc Exon Structure for

Expression for USP41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP41 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP41

genes like me logo Genes that share expression patterns with USP41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP41 Gene

Orthologs for USP41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP41 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP18 31
  • 83 (a)
(Bos Taurus)
Mammalia USP18 31
  • 73 (a)
(Canis familiaris)
Mammalia -- 31
  • 73 (a)
(Mus musculus)
Mammalia Usp18 31
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 55 (a)
(Gallus gallus)
Aves -- 31
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
(Danio rerio)
Actinopterygii CU571169.4 31
  • 27 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Ubp64E 31
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T05H10.1 31
  • 6 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP15 31
  • 6 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 7 (a)
Species where no ortholog for USP41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for USP41 Gene

Gene Tree for USP41 (if available)
Gene Tree for USP41 (if available)
Evolutionary constrained regions (ECRs) for USP41: view image

Paralogs for USP41 Gene

(3) SIMAP similar genes for USP41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP41: view

Variants for USP41 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP41 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs2277833 - p.Asn325Ser
rs2542134 - p.Tyr130Cys

Additional dbSNP identifiers (rs#s) for USP41 Gene

Variation tolerance for USP41 Gene

Gene Damage Index Score: 10.54; 91.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP41 Gene

Disorders for USP41 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP41 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrichosis universalis congenita, ambras type
  • htc1
- elite association - COSMIC cancer census association via MalaCards
Search USP41 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with USP41: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP41 Gene

Publications for USP41 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. (PMID: 27434537) Pinilla-Vera M … Lee JS (PloS one 2016) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for USP41 Gene

Sources for USP41 Gene