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USP41 Gene(Protein Coding)

Ubiquitin Specific Peptidase 41

GCID:
GC22M020350
GIFtS:
25
Genes Participants
UDN Logo

Aliases for USP41 Gene

Aliases for USP41 Gene

  • Ubiquitin Specific Peptidase 41 2 3 5
  • Ubiquitin-Specific-Processing Protease 41 4
  • Ubiquitin Specific Protease 41 2
  • Deubiquitinating Enzyme 41 4
  • Ubiquitin Thioesterase 41 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56

External Ids for USP41 Gene

Previous GeneCards Identifiers for USP41 Gene

  • GC00U909401
  • GC22U900095
  • GC22M018726
  • GC22M019022
  • GC22M020704
  • GC22M003968

Summaries for USP41 Gene

GeneCards Summary for USP41 Gene

USP41 (Ubiquitin Specific Peptidase 41) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP18.

UniProtKB/Swiss-Prot for USP41 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Additional gene information for USP41 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP41 Gene

Genomics for USP41 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for USP41 Gene

Promoters and enhancers for USP41 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I020462 Enhancer 0.8 Ensembl ENCODE 11.4 -73.3 -73271 2.8 PHF21A ZNF740 YBX1 POLR2A TARDBP PRDM10 RUNX3 SPI1 MED15 SCARF2 RNU6-225P KLHL22 ZNF74 USP41 ENSG00000236003 LZTR1 RNY1P9 PIR53917
GH22I020371 Enhancer 0.3 Ensembl 0.4 +19.0 19039 0.7 ZNF280A GC22P020363 GC22P020364 GC22P020366 GC22P020368 GC22P020369 GC22P020371 GC22P020372 GC22P020374 PIR42203 USP41
GH22I020364 Enhancer 0.4 Ensembl 0.3 +25.9 25931 0.9 CEBPB CEBPG ZNF507 DGCR6L GC22P020363 GC22P020364 GC22P020366 GC22P020368 GC22P020369 GC22P020371 GC22P020372 GC22P020374 PIR42203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP41 gene promoter:

Genomic Locations for USP41 Gene

Genomic Locations for USP41 Gene
chr22:20,350,578-20,390,758
(GRCh38/hg38)
Size:
40,181 bases
Orientation:
Minus strand
chr22:20,704,868-20,745,048
(GRCh37/hg19)

Genomic View for USP41 Gene

Genes around USP41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP41 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for USP41 Gene

Proteins for USP41 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for USP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LFD5-UBP41_HUMAN
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 41
    Protein Accession:
    Q3LFD5
    Secondary Accessions:
    • A8MXD0
    • Q70BM7

    Protein attributes for USP41 Gene

    Size:
    358 amino acids
    Molecular mass:
    41394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP41 Gene

Selected DME Specific Peptides for USP41 Gene

Q3LFD5:
  • VDGKWFCFNDS
  • LLLLEKMQDSRQKA
  • ILKRITVPR

Post-translational modifications for USP41 Gene

No Post-translational modifications

Other Protein References for USP41 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP41 Gene

Gene Families for USP41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP41 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for USP41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LFD5

UniProtKB/Swiss-Prot:

UBP41_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP41: view

Function for USP41 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for USP41 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP41 Gene

Gene Ontology (GO) - Molecular Function for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP41: view
genes like me logo Genes that share phenotypes with USP41: view

Animal Model Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP41 Gene

Localization for USP41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP41 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for USP41 Gene

Pathways & Interactions for USP41 Gene

genes like me logo Genes that share pathways with USP41: view

Gene Ontology (GO) - Biological Process for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP41: view

No data available for SIGNOR curated interactions for USP41 Gene

Drugs & Compounds for USP41 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for USP41 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for USP41 Gene

(2) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP41 Gene

No ASD Table

Relevant External Links for USP41 Gene

GeneLoc Exon Structure for
USP41
ECgene alternative splicing isoforms for
USP41

Expression for USP41 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP41 Gene

mRNA expression in normal human tissues for USP41 Gene
mRNA expression by GTEx for USP41 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP41 Gene:

USP41
genes like me logo Genes that share expression patterns with USP41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP41 Gene

Orthologs for USP41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia USP18 34
  • 83 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia USP18 34
  • 73 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia -- 34
  • 73 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Usp18 34
  • 63 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 57 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 55 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves -- 34
  • 44 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 43 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii CU571169.4 34
  • 27 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Ubp64E 34
  • 6 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea T05H10.1 34
  • 6 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes UBP15 34
  • 6 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 7 (a)
 OneToMany
Species where no ortholog for USP41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP41 Gene

ENSEMBL:
Gene Tree for USP41 (if available)
TreeFam:
Gene Tree for USP41 (if available)

Paralogs for USP41 Gene

Paralogs for USP41 Gene

(3) SIMAP similar genes for USP41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP41: view

Variants for USP41 Gene

Sequence variations from dbSNP and Humsavar for USP41 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000336410 -- 20,368,340(-) T/C intron_variant
rs1000394418 -- 20,374,553(-) G/ intron_variant
rs1000494462 -- 20,363,500(-) C/T downstream_transcript_variant
rs1000631568 -- 20,363,357(-) T/C downstream_transcript_variant
rs1000704507 -- 20,376,155(-) A/C intron_variant

Variation tolerance for USP41 Gene

Gene Damage Index Score: 10.54; 91.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP41 Gene

Disorders for USP41 Gene

Additional Disease Information for USP41

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for USP41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP41 Gene

Publications for USP41 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 58
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. (PMID: 27434537) Pinilla-Vera M … Lee JS (PloS one 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for USP41 Gene

Sources for USP41 Gene

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