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Aliases for USP38 Gene

Aliases for USP38 Gene

  • Ubiquitin Specific Peptidase 38 2 3 5
  • Ubiquitin-Specific-Processing Protease 38 3 4
  • Ubiquitin Specific Protease 38 2 3
  • Deubiquitinating Enzyme 38 3 4
  • Ubiquitin Thioesterase 38 3 4
  • HP43.8KD 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 38 3
  • Ubiquitin Thiolesterase 38 3
  • EC 4
  • KIAA1891 4

External Ids for USP38 Gene

Previous GeneCards Identifiers for USP38 Gene

  • GC04P144572
  • GC04P144683
  • GC04P144463
  • GC04P144325
  • GC04P144106
  • GC04P139835

Summaries for USP38 Gene

GeneCards Summary for USP38 Gene

USP38 (Ubiquitin Specific Peptidase 38) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot for USP38 Gene

  • Deubiquitinating enzyme exhibiting a preference towards Lys-63-linked ubiquitin chains.

Additional gene information for USP38 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP38 Gene

Genomics for USP38 Gene

GeneHancer (GH) Regulatory Elements for USP38 Gene

Promoters and enhancers for USP38 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I143183 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 557.3 +1.9 1872 6.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 USP38 LOC105377623 ENSG00000250969
GH04I143472 Enhancer 0.6 dbSUPER 16.2 +290.7 290749 5.7 PKNOX1 FOXA2 RXRA MAX REST ELF1 RAD21 YY1 JUND ATF3 USP38 LOC105377623 GAB1 LOC100420464 ENSG00000250540 RPSAP36
GH04I143389 Enhancer 0.9 Ensembl dbSUPER 10.6 +205.0 204984 0.2 SOX13 FOXA2 SAP130 GATA3 RERE FOS ZNF600 CREM TCF7L2 MIXL1 GAB1 LOC105377623 USP38 RPSAP36 RPS2P20
GH04I143351 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +172.4 172439 11.6 FOXA2 FEZF1 ATF7 FOS RUNX3 CAVIN1 JUNB ZNF592 MEF2D GMEB1 USP38 SMARCA5 GAB1 RPS2P20 RPSAP36
GH04I143416 Enhancer 0.7 dbSUPER 9.9 +235.7 235739 8.5 PKNOX1 BACH1 ZNF384 EBF1 BMI1 RELA ATF7 ZSCAN29 IKZF2 RUNX3 GAB1 LOC105377623 USP38 RPSAP36 RPS2P20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP38 gene promoter:

Genomic Locations for USP38 Gene

Genomic Locations for USP38 Gene
38,958 bases
Plus strand

Genomic View for USP38 Gene

Genes around USP38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP38 Gene

Proteins for USP38 Gene

  • Protein details for USP38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 38
    Protein Accession:
    Secondary Accessions:
    • B3KX93
    • Q3ZCV1
    • Q8NDF5
    • Q96DK6
    • Q96PZ6
    • Q9BY55

    Protein attributes for USP38 Gene

    1042 amino acids
    Molecular mass:
    116546 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK26248.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71627.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03730.1; Type=Miscellaneous discrepancy; Note=The absence of the residues from Tyr-840 to Ser-871 is not the result of an alternative splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP38 Gene

    Alternative splice isoforms for USP38 Gene


neXtProt entry for USP38 Gene

Post-translational modifications for USP38 Gene

  • Ubiquitination at posLast=773773
  • Modification sites at PhosphoSitePlus

Other Protein References for USP38 Gene

No data available for DME Specific Peptides for USP38 Gene

Domains & Families for USP38 Gene

Gene Families for USP38 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP38 Gene

Suggested Antigen Peptide Sequences for USP38 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP38: view

Function for USP38 Gene

Molecular function for USP38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme exhibiting a preference towards Lys-63-linked ubiquitin chains.

Enzyme Numbers (IUBMB) for USP38 Gene

Phenotypes From GWAS Catalog for USP38 Gene

Gene Ontology (GO) - Molecular Function for USP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP38: view
genes like me logo Genes that share phenotypes with USP38: view

Animal Models for USP38 Gene

MGI Knock Outs for USP38:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP38

Clone Products

  • Addgene plasmids for USP38

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP38 Gene

Localization for USP38 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP38 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP38 Gene

Pathways & Interactions for USP38 Gene

genes like me logo Genes that share pathways with USP38: view

Pathways by source for USP38 Gene

1 BioSystems pathway for USP38 Gene
1 Qiagen pathway for USP38 Gene

Gene Ontology (GO) - Biological Process for USP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IDA 14715245
genes like me logo Genes that share ontologies with USP38: view

No data available for SIGNOR curated interactions for USP38 Gene

Drugs & Compounds for USP38 Gene

(1) Drugs for USP38 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP38: view

Transcripts for USP38 Gene

Unigene Clusters for USP38 Gene

Ubiquitin specific peptidase 38:
Representative Sequences:

Clone Products

  • Addgene plasmids for USP38

Alternative Splicing Database (ASD) splice patterns (SP) for USP38 Gene

No ASD Table

Relevant External Links for USP38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP38 Gene

mRNA differential expression in normal tissues according to GTEx for USP38 Gene

This gene is overexpressed in Muscle - Skeletal (x6.8).

Protein differential expression in normal tissues from HIPED for USP38 Gene

This gene is overexpressed in Tlymphocyte (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP38 Gene

Protein tissue co-expression partners for USP38 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP38 Gene:


SOURCE GeneReport for Unigene cluster for USP38 Gene:


mRNA Expression by UniProt/SwissProt for USP38 Gene:

Tissue specificity: Highly expressed in skeletal muscle. Expressed in adrenal gland.

Evidence on tissue expression from TISSUES for USP38 Gene

  • Nervous system(4.4)
  • Adrenal gland(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with USP38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP38 Gene

Orthologs for USP38 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP38 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia USP38 33 34
  • 91.09 (n)
(Canis familiaris)
Mammalia USP38 33 34
  • 90.1 (n)
(Mus musculus)
Mammalia Usp38 33 16 34
  • 87.46 (n)
(Rattus norvegicus)
Mammalia Usp38 33
  • 87.16 (n)
(Monodelphis domestica)
Mammalia USP38 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia USP38 34
  • 81 (a)
(Gallus gallus)
Aves USP38 33 34
  • 73.82 (n)
(Anolis carolinensis)
Reptilia USP38 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp38 33
  • 70.6 (n)
Str.10104 33
(Danio rerio)
Actinopterygii USP38 34
  • 64 (a)
usp38 33
  • 63.82 (n)
Dr.15383 33
fruit fly
(Drosophila melanogaster)
Insecta CG8830 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 34
  • 18 (a)
UBP9 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for USP38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP38 Gene

Gene Tree for USP38 (if available)
Gene Tree for USP38 (if available)

Paralogs for USP38 Gene

Paralogs for USP38 Gene

(3) SIMAP similar genes for USP38 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with USP38: view

Variants for USP38 Gene

Sequence variations from dbSNP and Humsavar for USP38 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000018269 -- 143,188,033(+) A/G intron_variant
rs10000911 -- 143,215,040(+) T/G 3_prime_UTR_variant, intron_variant
rs10001113 -- 143,215,252(+) T/C 3_prime_UTR_variant, intron_variant
rs1000148899 -- 143,184,691(+) C/G upstream_transcript_variant
rs1000270738 -- 143,213,703(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for USP38 Gene

Variant ID Type Subtype PubMed ID
esv3350576 CNV insertion 20981092
nsv1033902 CNV gain 25217958

Variation tolerance for USP38 Gene

Residual Variation Intolerance Score: 2.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP38 Gene

Disorders for USP38 Gene

Additional Disease Information for USP38

No disorders were found for USP38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP38 Gene

Publications for USP38 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 58
  5. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58

Products for USP38 Gene

  • Addgene plasmids for USP38

Sources for USP38 Gene

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