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USP38 (Ubiquitin Specific Peptidase 38) is a Protein Coding gene. Diseases associated with USP38 include Ullrich Congenital Muscular Dystrophy 1. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP35.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IDA | 14715245 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005829 | cytosol | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
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|
|
2 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
GO:0016579 | protein deubiquitination | IDA | 14715245 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Water | Approved | Pharma | 0 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | USP38 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | USP38 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | USP38 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Usp38 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Usp38 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | USP38 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | USP38 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | USP38 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | USP38 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp38 30 |
|
||
Str.10104 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | USP38 31 |
|
OneToOne | |
usp38 30 |
|
||||
Dr.15383 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8830 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP13 31 |
|
ManyToMany | |
UBP9 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3350576 | CNV | insertion | 20981092 |
nsv1033902 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ullrich congenital muscular dystrophy 1 |
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