Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded ... See more...
Aliases for USP36 Gene
Aliases for USP36 Gene
External Ids for USP36 Gene
- HGNC: 20062
- NCBI Entrez Gene: 57602
- Ensembl: ENSG00000055483
- OMIM®: 612543
- UniProtKB/Swiss-Prot: Q9P275
Previous GeneCards Identifiers for USP36 Gene
- GC17M077244
- GC17M077380
- GC17M074295
- GC17M076792
- GC17M072215
- GC17M076783
Summaries for USP36 Gene
-
This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
GeneCards Summary for USP36 Gene
USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP42.
UniProtKB/Swiss-Prot Summary for USP36 Gene
-
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).
Additional gene information for USP36 Gene
- HGNC (20062)
- NCBI Entrez Gene (57602)
- Ensembl (ENSG00000055483)
- OMIM® (612543)
- UniProtKB/Swiss-Prot (Q9P275)
- Open Targets Platform(ENSG00000055483)
- Search for USP36 at DataMed
- Search for USP36 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP36 Gene
Genomics for USP36 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for USP36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around USP36 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP36
- Top Transcription factor binding sites by QIAGEN in the USP36 gene promoter:
-
- AML1a
- AREB6
- Egr-3
- GCNF-2
- HOXA9
- HOXA9B
- Meis-1
- Meis-1a
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for USP36 Gene
Latest Assembly
- chr17:78,787,381-78,841,441
- (GRCh38/hg38)
- Size:
- 54,061 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:76,783,463-76,837,521
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 54,059 bases
- Orientation:
- Minus strand
- chr17:76,783,463-76,837,523
- (GRCh37/hg19 by Ensembl)
- Size:
- 54,061 bases
- Orientation:
- Minus strand
Genomic View for USP36 Gene
Genes around USP36 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
USP36 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for USP36 Gene
Proteins for USP36 Gene
-
Protein details for USP36 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P275-UBP36_HUMAN
- Recommended name:
- Ubiquitin carboxyl-terminal hydrolase 36
- Protein Accession:
- Q9P275
- Q05C98
- Q05DD0
- Q6IQ38
- Q8NDM8
- Q9NVC8
Protein attributes for USP36 Gene
- Size:
- 1123 amino acids
- Molecular mass:
- 122908 Da
- Quaternary structure:
-
- Interacts with isoform 3 of FBXW7; the interaction inhibits MYC degradation induced by SCF(FBW7) complex (PubMed:25775507). Interacts with NTRK1; USP36 does not deubiquitinate NTRK1 (PubMed:27445338). Interacts with NEDD4L (via domains WW1, 3 and 4); the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L (PubMed:27445338).
- SequenceCaution:
-
- Sequence=AAH16487.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95977.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for USP36 Gene
Selected DME Specific Peptides for USP36 Gene
- Q9P275:
-
- QCLTYTPPLANY
- NLGNTCF
Post-translational modifications for USP36 Gene
- Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels.
-
Ubiquitination at Lys338
- NX_Q9P275 (NX_Q9P275-1)
- Modification sites at PhosphoSitePlus
Other Protein References for USP36 Gene
- ENSEMBL proteins:
-
- ENSP00000465679
- ENSP00000464746
- ENSP00000468356
- ENSP00000467280
- ENSP00000464886
- ENSP00000465698
- ENSP00000441214
- ENSP00000468549
- ENSP00000466567
- ENSP00000466187
- ENSP00000467682
- ENSP00000467520
- ENSP00000475654
- ENSP00000467951
- ENSP00000466212
- ENSP00000468194
- ENSP00000465183
- ENSP00000310590
- ENSP00000401119
- Q9P275.173
- REFSEQ proteins:
-
- XP_011523367.1
- XP_011523368.1
- XP_011523370.1
- XP_011523371.1
- XP_011523372.1
- XP_011523373.1
- XP_016880390.1
- XP_024306613.1
- XP_024306614.1
- NP_001308220.1
- NP_001372098.1
- NP_001372099.1
- NP_001372100.1
- NP_001372101.1
- NP_001372102.1
- NP_001372103.1
- NP_001372104.1
- NP_001372105.1
- NP_001372106.1
- NP_001372107.1
- NP_001372108.1
- NP_001372109.1
Antibodies for research
- LifeSpan BioSciences USP36 Antibody
- G Biosciences Immunotagā¢ USP36 Antibody
- HUABIO USP36 Antibody (ER1706-23)
- Novus Biologicals Antibodies for USP36
-
Abcam antibodies for USP36
- Invitrogen Antibodies for USP36 (AFLGC-USP36)
-
Custom Antibody ServicesProSci Antibodies for USP36
- Sino Biological Antibodies for USP36
Protein products for research
-
OriGene Purified Proteins for USP36
- Search Origene for MassSpec and Protein Over-expression Lysates for USP36
- Origene Custom Protein Services for USP36
Assay products for research
Domains & Families for USP36 Gene
Gene Families for USP36 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for USP36 Gene
- InterPro:
- Blocks:
-
- Ubiquitin thiolesterase, family 2
- ProtoNet:
Suggested Antigen Peptide Sequences for USP36 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin carboxyl-terminal hydrolase (F5H3B9_HUMAN)
- USP36 protein (Q8IXW9_HUMAN)
- Ubiquitin carboxyl-terminal hydrolase (Q9H9C5_HUMAN)
- Ubiquitin-specific-processing protease 36 (UBP36_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9P275- Family:
-
- Belongs to the peptidase C19 family.
Function for USP36 Gene
Molecular function for USP36 Gene
- UniProtKB/Swiss-Prot Function:
- Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:14715245};.
Enzyme Numbers (IUBMB) for USP36 Gene
Phenotypes From GWAS Catalog for USP36 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IEA,IDA | 14715245 |
| GO:0005515 | protein binding | IPI | 25775507 |
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for USP36 Gene
- MGI mutant phenotypes for USP36:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for USP36:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 25%
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased cilium length after serum starvation
- Increased G2M DNA content
- Decreased cilium length
Animal Models for USP36 Gene
- MGI Knock Outs for USP36:
-
- Usp36 Usp36<tm1b(EUCOMM)Hmgu>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for USP36 - Starting at $85 >
- * USP36 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for USP36
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP36
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP36
miRNA for USP36 Gene
- miRTarBase miRNAs that target USP36
-
- mmu-miR-223-3p (MIRT009661)
- hsa-miR-98-5p (MIRT027793)
- hsa-miR-342-5p (MIRT038207)
- hsa-miR-615-3p (MIRT040098)
- hsa-miR-151a-3p (MIRT043617)
- hsa-miR-4531 (MIRT451768)
- hsa-miR-582-5p (MIRT451769)
- hsa-miR-101-3p (MIRT451770)
- hsa-miR-5703 (MIRT451771)
- hsa-miR-4516 (MIRT451772)
- hsa-miR-4434 (MIRT451773)
- hsa-miR-6077 (MIRT451774)
- hsa-miR-6124 (MIRT451775)
- hsa-miR-873-3p (MIRT451776)
- hsa-miR-6770-5p (MIRT451777)
- hsa-miR-7515 (MIRT451778)
- hsa-miR-6080 (MIRT451779)
- hsa-miR-6840-3p (MIRT451780)
- hsa-miR-101-5p (MIRT451781)
- hsa-miR-6849-5p (MIRT451782)
- hsa-miR-3681-5p (MIRT451783)
- hsa-miR-329-5p (MIRT451784)
- hsa-miR-4499 (MIRT451785)
- hsa-miR-9500 (MIRT451786)
- hsa-miR-3154 (MIRT451787)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP36
- Browse OriGene Inhibitory RNA Products For USP36
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP36
Clone products for research
- Applied Biological Materials (abm): Clones for USP36 - Starting at $45 >
- * USP36 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for USP36
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP36
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP36 Gene
Localization for USP36 Gene
Subcellular locations from UniProtKB/Swiss-Prot for USP36 Gene
- Nucleus, nucleolus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli (4)
- Nucleoli rim (4)
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | 19208757 |
| GO:0005737 | cytoplasm | IEA,IDA | 27445338 |
| GO:0005829 | cytosol | IBA | 21873635 |
Pathways & Interactions for USP36 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
-
|
|
Pathways by source for USP36 Gene
1 Qiagen pathway for USP36 Gene
- Ubiquitin-Proteasome Dependent Proteolysis
Interacting Proteins for USP36 Gene
GPS-Prot Interaction Network for USP36
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0007000 | nucleolus organization | ISS | -- |
| GO:0016242 | negative regulation of macroautophagy | IMP | 22622177 |
| GO:0016578 | histone deubiquitination | IMP | 29274341 |
No data available for SIGNOR curated interactions for USP36 Gene
Drugs & Compounds for USP36 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 |
Transcripts for USP36 Gene
mRNA/cDNA for USP36 Gene
- 14 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000312010 5234 nts (view in UCSC)
- ENST00000449938 1647 nts (view in UCSC)
- ENST00000542802 6063 nts (view in UCSC)
- ENST00000586066 960 nts (view in UCSC)
- ENST00000586531 898 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for USP36 - Starting at $85 >
- * USP36 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for USP36
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP36
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP36
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP36
- Browse OriGene Inhibitory RNA Products For USP36
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP36
Clone products for research
- Applied Biological Materials (abm): Clones for USP36 - Starting at $45 >
- * USP36 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for USP36
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP36
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | · | 4g | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: |
| ExUns: | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | · | 28c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - |
| ExUns: | 28d | ^ | 29 | ^ | 30 | ^ | 31 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | - | ||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: | |||||||
| SP14: | |||||||
| SP15: | |||||||
| SP16: | |||||||
| SP17: | |||||||
| SP18: | - | - | - | ||||
| SP19: | |||||||
| SP20: | |||||||
| SP21: | |||||||
| SP22: |
Relevant External Links for USP36 Gene
- GeneLoc Exon Structure for
- USP36
Expression for USP36 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Blood (Hematopoietic System)
-
Breast (Uncategorized)
This gene is overexpressed in Peripheral blood mononuclear cells (19.2), Rectum (17.6), Pancreatic juice (8.4), and Uterus (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP36 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP36
SOURCE GeneReport for Unigene cluster for USP36 Gene:
Hs.464243mRNA Expression by UniProt/SwissProt for USP36 Gene:
Q9P275-UBP36_HUMAN
Tissue specificity:
Broadly expressed.
Evidence on tissue expression from TISSUES for USP36 Gene
- Nervous system(4.7)
- Skin(4.4)
- Intestine(2.9)
- Lung(2.7)
Primer products for research
-
OriGene qPCR primer pairs for USP36
-
OriGene qPCR primer pairs and template standards for USP36
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP36 Gene
Orthologs for USP36 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | USP36 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | USP36 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Usp36 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | USP36 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Usp36 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | USP36 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | USP36 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | USP36 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398902 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | usp36 31 |
|
OneToOne | |
| wufd19b04 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12981 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | scny 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP8 31 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ubp16 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2285 30 |
|
- Species where no ortholog for USP36 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for USP36 Gene
- ENSEMBL:
- Gene Tree for USP36 (if available)
- TreeFam:
- Gene Tree for USP36 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for USP36: view image
Paralogs for USP36 Gene
Paralogs for USP36 Gene
- USP42 5
- USP17L1 5
- USP17L4 5
- USP17L8 5
- USP17L3 5
- USP17L2 5
- USP17L10 5
- USP17L11 5
- USP17L12 5
- USP17L13 5
- USP17L15 5
- USP17L17 5
- USP17L18 5
- USP17L19 5
- USP17L20 5
- USP17L21 5
- USP17L22 5
- USP17L24 5
- USP17L25 5
- USP17L26 5
- USP17L5 5
- USP17L27 5
- USP17L28 5
- USP17L29 5
- USP17L30 5
- USP17L7 5
- USP31 5
- USP43 5
- USP32 5
- USP47 5
- USP7 5
- USP38 5
- USP6 5
- USP35 5
- USP25 5
- USP16 5
- USP9X 5
- USP48 5
- USP49 5
- USP34 5
- USP19 5
- USP4 5
- USP20 5
- USP10 5
- USP44 5
- USP40 5
- USP9Y 5
- USP11 5
- USP8 5
- USP22 5
- USP45 5
- USP24 5
- USP15 5
- USP33 5
- USP28 5
- USP2 5
- USP14 5
- USP27X 5
- USP51 5
- USP3 5
- USP1 5
- USP21 5
- USP17L23 5
- USP5 5
- USP30 5
- USP13 5
- USP50 5
- USP26 5
- USP29 5
- USP37 5
- USP18 5
- USP41 5
(34) SIMAP similar genes for USP36 Gene using alignment to 16 proteins:
- UBP36_HUMAN
- E9PEW0_HUMAN
- K7EIH0_HUMAN
- K7EIT7_HUMAN
- K7EJI3_HUMAN
- K7EKL7_HUMAN
- K7EKN3_HUMAN
- K7ELR5_HUMAN
- K7ELT3_HUMAN
- K7EMM6_HUMAN
- K7EPT1_HUMAN
- K7EQS0_HUMAN
- K7ERC1_HUMAN
- K7ERP8_HUMAN
- Q8IXW9_HUMAN
- U3KQ92_HUMAN
Variants for USP36 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP36 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117840411 | Benign: not provided | 78,812,937(-) |
C/T NM_001321291.1(USP36):c.1330G>A (p.Gly444Ser) |
MISSENSE | |
| rs140328430 | Benign: not provided | 78,807,608(-) |
G/A NM_001321291.1(USP36):c.1436C>T (p.Pro479Leu) |
MISSENSE | |
| rs143307341 | Benign: not provided | 78,806,238(-) |
G/T NM_001321291.1(USP36):c.2134C>A (p.Pro712Thr) |
MISSENSE | |
| rs147635914 | Benign: not provided | 78,828,991(-) |
G/A NM_001321291.1(USP36):c.492C>T (p.Phe164=) |
SYNONYMOUS | |
| rs147867694 | Likely Benign: not provided | 78,818,724(-) |
G/A NM_001321291.1(USP36):c.966C>T (p.Asn322=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3641341 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.63;
89.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for USP36 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP36 Gene
Disorders for USP36 Gene
Additional Disease Information for USP36
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for USP36 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP36 Gene
Publications for USP36 Gene
- The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase. (PMID: 29274341) DeVine T ā¦ Dai MS (Biochemical and biophysical research communications 2018) 3 4
- Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). (PMID: 27445338) Anta B ā¦ Arévalo JC (The Journal of biological chemistry 2016) 3 4
- The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. (PMID: 25775507) Sun XX ā¦ Dai MS (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4
- The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. (PMID: 22622177) Taillebourg E ā¦ Fauvarque MO (Autophagy 2012) 3 4
- Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36. (PMID: 21268071) Kim MS ā¦ Baek KH (Journal of cellular biochemistry 2011) 3 4
ExternalLinks
Products for USP36 Gene
- Custom Antibody ServicesOriGene Antibodies for USP36
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for USP36
- Search Origene for MassSpec and Protein Over-expression Lysates for USP36
- Origene Custom Protein Services for USP36
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP36
- Browse OriGene Inhibitory RNA Products For USP36
- OriGene qPCR primer pairs for USP36
- OriGene qPCR primer pairs and template standards for USP36
- OriGene CRISPR knockouts for USP36
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For USP36
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for USP36
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for USP36
- Novus Biologicals proteins and lysates for USP36
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for USP36
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for USP36 (AFLGC-USP36)
- VectorBuilder Custom and pre-made DNA vectors for USP36 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for USP36 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for USP36 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for USP36 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for USP36
- Addgene plasmids for USP36
- antibodies-online: Show 14 available USP36 Antibodies ranked by validation data
- Compare Top USP36 Antibodies
- antibodies-online: Search results for available USP36 related products ranked by validation data
- antibodies-online: Search results for available USP36 related products ranked by validation data
- Custom Antibody ServicesProSci Antibodies for USP36
- Search for USP36 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP36
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP36
- Search GeneCopoeia for miRNA 3'UTR Target clone products for USP36
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP36
Sources for USP36 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25)