This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded ... See more...

Aliases for USP36 Gene

Aliases for USP36 Gene

  • Ubiquitin Specific Peptidase 36 2 3 5
  • Ubiquitin-Specific-Processing Protease 36 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 36 3 4
  • Ubiquitin Specific Protease 36 2 3
  • Deubiquitinating Enzyme 36 3 4
  • Ubiquitin Thioesterase 36 3 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 54
  • AC022966.1 5
  • KIAA1453 4
  • DUB1 3

External Ids for USP36 Gene

Previous GeneCards Identifiers for USP36 Gene

  • GC17M077244
  • GC17M077380
  • GC17M074295
  • GC17M076792
  • GC17M072215
  • GC17M076783

Summaries for USP36 Gene

Entrez Gene Summary for USP36 Gene

  • This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

GeneCards Summary for USP36 Gene

USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP42.

UniProtKB/Swiss-Prot Summary for USP36 Gene

  • Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).

Gene Wiki entry for USP36 Gene

Additional gene information for USP36 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP36 Gene

Genomics for USP36 Gene

GeneHancer (GH) Regulatory Elements for USP36 Gene

Promoters and enhancers for USP36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J078838 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 818.6 +0.9 904 4.1 SIN3A ZBTB40 SP1 SREBF1 MLX RBPJ SMARCE1 POLR2A CTBP1 USF2 USP36 lnc-C1QTNF1-8 lnc-TIMP2-1 BIRC5 TNRC6C ENGASE piR-43106-098
GH17J078836 Promoter 0.3 EPDnew 750.4 +5.0 5030 0.1 USP36 lnc-TIMP2-1 piR-43106-098
GH17J078557 Enhancer 1.2 Ensembl ENCODE 149 +283.4 283408 1.7 ZNF785 ZBTB6 MLX RBPJ SMARCE1 CTBP1 NR2F1 NR2F6 ATF1 CREB1 USP36 TNRC6C DNAH17 ENGASE RNU6-638P RPL9P29 CANT1 lnc-CYTH1-2
GH17J078349 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 66.3 +485.6 485576 11.9 SIN3A ZNF24 ZBTB40 SP1 CTCF SREBF1 FOXA1 ZBTB6 RBPJ SMARCE1 SOCS3 USP36 ENGASE PGS1 CANT1 LOC101928674 CYTH1 BIRC5 TMC6 TMC8
GH17J078733 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 72.6 +94.6 94589 27 ZNF24 SP1 CTCF LCORL FOXA1 ZBTB6 MLX RBPJ SMARCE1 POLR2A CYTH1 USP36 SOCS3 RNU6-638P TNRC6C DNAH17 ENGASE TNRC6C-AS1 PGS1 lnc-C1QTNF1-9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP36 gene promoter:
  • AML1a
  • AREB6
  • Egr-3
  • GCNF-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for USP36 Gene

Genomic Locations for USP36 Gene
chr17:78,787,381-78,841,441
(GRCh38/hg38)
Size:
54,061 bases
Orientation:
Minus strand
chr17:76,783,463-76,837,523
(GRCh37/hg19)
Size:
54,061 bases
Orientation:
Minus strand

Genomic View for USP36 Gene

Genes around USP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP36 Gene

Proteins for USP36 Gene

  • Protein details for USP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P275-UBP36_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36
    Protein Accession:
    Q9P275
    Secondary Accessions:
    • Q05C98
    • Q05DD0
    • Q6IQ38
    • Q8NDM8
    • Q9NVC8

    Protein attributes for USP36 Gene

    Size:
    1123 amino acids
    Molecular mass:
    122908 Da
    Quaternary structure:
    • Interacts with isoform 3 of FBXW7; the interaction inhibits MYC degradation induced by SCF(FBW7) complex (PubMed:25775507). Interacts with NTRK1; USP36 does not deubiquitinate NTRK1 (PubMed:27445338). Interacts with NEDD4L (via domains WW1, 3 and 4); the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L (PubMed:27445338).
    SequenceCaution:
    • Sequence=AAH16487.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95977.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for USP36 Gene

Selected DME Specific Peptides for USP36 Gene

Q9P275:
  • QCLTYTPPLANY
  • NLGNTCF

Post-translational modifications for USP36 Gene

  • Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels.
  • Ubiquitination at Lys338
  • Modification sites at PhosphoSitePlus

Domains & Families for USP36 Gene

Gene Families for USP36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP36 Gene

Suggested Antigen Peptide Sequences for USP36 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin carboxyl-terminal hydrolase (F5H3B9_HUMAN)
  • USP36 protein (Q8IXW9_HUMAN)
  • Ubiquitin carboxyl-terminal hydrolase (Q9H9C5_HUMAN)
  • Ubiquitin-specific-processing protease 36 (UBP36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P275

UniProtKB/Swiss-Prot:

UBP36_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP36: view

Function for USP36 Gene

Molecular function for USP36 Gene

UniProtKB/Swiss-Prot Function:
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=. ;.

Enzyme Numbers (IUBMB) for USP36 Gene

Phenotypes From GWAS Catalog for USP36 Gene

Gene Ontology (GO) - Molecular Function for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 25775507
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with USP36: view
genes like me logo Genes that share phenotypes with USP36: view

Animal Models for USP36 Gene

MGI Knock Outs for USP36:
  • Usp36 Usp36<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for USP36

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP36 Gene

Localization for USP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP36 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP36 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA 19208757
GO:0005737 cytoplasm IDA,IEA 27445338
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with USP36: view

Pathways & Interactions for USP36 Gene

PathCards logo

SuperPathways for USP36 Gene

SuperPathway Contained pathways
1 Ubiquitin-Proteasome Dependent Proteolysis
-
genes like me logo Genes that share pathways with USP36: view

Pathways by source for USP36 Gene

1 Qiagen pathway for USP36 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis

Gene Ontology (GO) - Biological Process for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007000 nucleolus organization ISS --
GO:0016242 negative regulation of macroautophagy IMP 22622177
GO:0016578 histone deubiquitination IMP 29274341
genes like me logo Genes that share ontologies with USP36: view

No data available for SIGNOR curated interactions for USP36 Gene

Drugs & Compounds for USP36 Gene

(1) Drugs for USP36 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP36: view

Transcripts for USP36 Gene

mRNA/cDNA for USP36 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for USP36

Alternative Splicing Database (ASD) splice patterns (SP) for USP36 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: -
SP2: - - - - - - - -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ·
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22: -

ExUns: 28d ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

Relevant External Links for USP36 Gene

GeneLoc Exon Structure for
USP36
ECgene alternative splicing isoforms for
USP36

Expression for USP36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.2), Rectum (17.6), Pancreatic juice (8.4), and Uterus (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP36 Gene



NURSA nuclear receptor signaling pathways regulating expression of USP36 Gene:

USP36

SOURCE GeneReport for Unigene cluster for USP36 Gene:

Hs.464243

mRNA Expression by UniProt/SwissProt for USP36 Gene:

Q9P275-UBP36_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for USP36 Gene

  • Nervous system(4.6)
  • Skin(4.3)
  • Intestine(2.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with USP36: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP36 Gene

Orthologs for USP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP36 33 32
  • 98.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia USP36 33 32
  • 80.64 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp36 32
  • 79.85 (n)
cow
(Bos Taurus)
Mammalia USP36 33 32
  • 78.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Usp36 17 33 32
  • 78.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 67 (a)
OneToMany
-- 33
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia USP36 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP36 33 32
  • 72.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP36 33
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398902 32
zebrafish
(Danio rerio)
Actinopterygii usp36 33
  • 52 (a)
OneToOne
wufd19b04 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12981 32
fruit fly
(Drosophila melanogaster)
Insecta scny 33
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 33
  • 22 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp16 32
  • 50.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2285 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2285 32
Species where no ortholog for USP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP36 Gene

ENSEMBL:
Gene Tree for USP36 (if available)
TreeFam:
Gene Tree for USP36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP36: view image

Paralogs for USP36 Gene

(34) SIMAP similar genes for USP36 Gene using alignment to 16 proteins:

  • UBP36_HUMAN
  • E9PEW0_HUMAN
  • K7EIH0_HUMAN
  • K7EIT7_HUMAN
  • K7EJI3_HUMAN
  • K7EKL7_HUMAN
  • K7EKN3_HUMAN
  • K7ELR5_HUMAN
  • K7ELT3_HUMAN
  • K7EMM6_HUMAN
  • K7EPT1_HUMAN
  • K7EQS0_HUMAN
  • K7ERC1_HUMAN
  • K7ERP8_HUMAN
  • Q8IXW9_HUMAN
  • U3KQ92_HUMAN
genes like me logo Genes that share paralogs with USP36: view

Variants for USP36 Gene

Sequence variations from dbSNP and Humsavar for USP36 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000051845 -- 78,822,350(-) A/C intron_variant
rs1000068866 -- 78,803,000(-) G/A intron_variant
rs1000069740 -- 78,835,647(-) G/A intron_variant
rs1000094026 -- 78,789,058(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000144261 -- 78,794,198(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USP36 Gene

Variant ID Type Subtype PubMed ID
esv3641341 CNV loss 21293372

Variation tolerance for USP36 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.63; 89.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP36 Gene

Human Gene Mutation Database (HGMD)
USP36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP36

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP36 Gene

Disorders for USP36 Gene

Additional Disease Information for USP36

No disorders were found for USP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP36 Gene

Publications for USP36 Gene

  1. The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase. (PMID: 29274341) DeVine T … Dai MS (Biochemical and biophysical research communications 2018) 3 4 56
  2. Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). (PMID: 27445338) Anta B … Arévalo JC (The Journal of biological chemistry 2016) 3 4 56
  3. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. (PMID: 25775507) Sun XX … Dai MS (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 56
  4. The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. (PMID: 22622177) Taillebourg E … Fauvarque MO (Autophagy 2012) 3 4 56
  5. Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36. (PMID: 21268071) Kim MS … Baek KH (Journal of cellular biochemistry 2011) 3 4 56

Products for USP36 Gene

Sources for USP36 Gene