Aliases for USP34 Gene
External Ids for USP34 Gene
Previous GeneCards Identifiers for USP34 Gene
GeneCards Summary for USP34 Gene
USP34 (Ubiquitin Specific Peptidase 34) is a Protein Coding gene. Diseases associated with USP34 include Chromosome 2P16.1-P15 Deletion Syndrome and Meningocele. Among its related pathways are Metabolism of proteins and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP20.
UniProtKB/Swiss-Prot Summary for USP34 Gene
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.