Aliases for USP34 Gene
External Ids for USP34 Gene
Previous GeneCards Identifiers for USP34 Gene
GeneCards Summary for USP34 Gene
USP34 (Ubiquitin Specific Peptidase 34) is a Protein Coding gene. Diseases associated with USP34 include Chromosome 2P16.1-P15 Deletion Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Signaling by GPCR and Deubiquitination. Gene Ontology (GO) annotations related to this gene include binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP24.
UniProtKB/Swiss-Prot Summary for USP34 Gene
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.