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Aliases for USP34 Gene

Aliases for USP34 Gene

  • Ubiquitin Specific Peptidase 34 2 3 5
  • Ubiquitin-Specific-Processing Protease 34 4
  • Ubiquitin Specific Protease 34 2
  • Deubiquitinating Enzyme 34 4
  • Ubiquitin Thioesterase 34 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56
  • KIAA0570 4
  • KIAA0729 4

External Ids for USP34 Gene

Previous GeneCards Identifiers for USP34 Gene

  • GC02M061372
  • GC02M061389
  • GC02M061327
  • GC02M061414

Summaries for USP34 Gene

GeneCards Summary for USP34 Gene

USP34 (Ubiquitin Specific Peptidase 34) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP9X.

UniProtKB/Swiss-Prot for USP34 Gene

  • Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Gene Wiki entry for USP34 Gene

Additional gene information for USP34 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP34 Gene

Genomics for USP34 Gene

GeneHancer (GH) Regulatory Elements for USP34 Gene

Promoters and enhancers for USP34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I061468 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.1 +0.2 164 4.7 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 USP34 LOC105377633 LOC339803 AHSA2P PAPOLG PEX13 PUS10 SNORA70B
GH02I061534 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 47.2 -66.6 -66621 5.2 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 XPO1 CCT4 USP34 AHSA2P ENSG00000232713 REL LOC339803 PAPOLG NONOP2 ENSG00000236498
GH02I061015 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 41.3 +452.9 452871 4.4 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PUS10 PEX13 AHSA2P USP34 CCT4 PAPOLG ENSG00000232713 ENSG00000236498 NONOP2 XPO1
GH02I061853 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.2 -383.7 -383703 2.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 E2F8 ZNF207 FAM161A CCT4 USP34 NONOP2 ENSG00000232713 REL XPO1 AHSA2P PEX13 PIR42567
GH02I062194 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -726.9 -726918 7.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 B3GNT2 XPO1 USP34 LOC105377633 MIR5192 GC02P062192 GC02M062151
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP34 gene promoter:

Genomic Locations for USP34 Gene

Genomic Locations for USP34 Gene
chr2:61,187,455-61,470,769
(GRCh38/hg38)
Size:
283,315 bases
Orientation:
Minus strand
chr2:61,414,590-61,697,904
(GRCh37/hg19)

Genomic View for USP34 Gene

Genes around USP34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP34 Gene

Proteins for USP34 Gene

  • Protein details for USP34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ2-UBP34_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 34
    Protein Accession:
    Q70CQ2
    Secondary Accessions:
    • A8MWD0
    • B3KWU9
    • O60316
    • O94834
    • Q3B777
    • Q6P6C9
    • Q7L8P6
    • Q8N3T9
    • Q8TBW2
    • Q9UGA1

    Protein attributes for USP34 Gene

    Size:
    3546 amino acids
    Molecular mass:
    404233 Da
    Quaternary structure:
    • Interacts with AXIN1 and AXIN2.
    SequenceCaution:
    • Sequence=AAI07762.1; Type=Frameshift; Positions=3200; Evidence={ECO:0000305}; Sequence=BAA25496.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG54261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP34 Gene

Selected DME Specific Peptides for USP34 Gene

Q70CQ2:
  • IQQLYMIP
  • GSSGPGS

Post-translational modifications for USP34 Gene

  • Ubiquitination at isoforms=2, 3484, posLast=15741574, posLast=19681968, isoforms=2, 32100, isoforms=2, 32102, and isoforms=2, 32219

Other Protein References for USP34 Gene

Domains & Families for USP34 Gene

Gene Families for USP34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q70CQ2

UniProtKB/Swiss-Prot:

UBP34_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP34: view

Function for USP34 Gene

Molecular function for USP34 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Enzyme Numbers (IUBMB) for USP34 Gene

Phenotypes From GWAS Catalog for USP34 Gene

Gene Ontology (GO) - Molecular Function for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 21383061
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 21383061
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP34: view
genes like me logo Genes that share phenotypes with USP34: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP34 Gene

Localization for USP34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP34 gene
Compartment Confidence
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP34 Gene

Pathways & Interactions for USP34 Gene

genes like me logo Genes that share pathways with USP34: view

Pathways by source for USP34 Gene

Gene Ontology (GO) - Biological Process for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016055 Wnt signaling pathway TAS --
GO:0016579 protein deubiquitination TAS,IEA --
GO:0071108 protein K48-linked deubiquitination IDA 21383061
genes like me logo Genes that share ontologies with USP34: view

No data available for SIGNOR curated interactions for USP34 Gene

Drugs & Compounds for USP34 Gene

No Compound Related Data Available

Transcripts for USP34 Gene

Unigene Clusters for USP34 Gene

Ubiquitin specific peptidase 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:

ExUns: 41a · 41b ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58a · 58b ^ 59a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15: - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 59b ^ 60a · 60b · 60c · 60d ·
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for USP34 Gene

GeneLoc Exon Structure for
USP34
ECgene alternative splicing isoforms for
USP34

Expression for USP34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP34 Gene

This gene is overexpressed in Adrenal (12.4), Ovary (12.1), Placenta (8.9), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP34 Gene



Protein tissue co-expression partners for USP34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP34 Gene:

USP34

SOURCE GeneReport for Unigene cluster for USP34 Gene:

Hs.644708

mRNA Expression by UniProt/SwissProt for USP34 Gene:

Q70CQ2-UBP34_HUMAN
Tissue specificity: Expressed in brain at low level.

Evidence on tissue expression from TISSUES for USP34 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with USP34: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP34 Gene

Orthologs for USP34 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP34 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia USP34 33 34
  • 95.16 (n)
cow
(Bos Taurus)
Mammalia USP34 33 34
  • 94.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia USP34 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP34 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp34 33 16 34
  • 92.36 (n)
rat
(Rattus norvegicus)
Mammalia Usp34 33
  • 90.78 (n)
chicken
(Gallus gallus)
Aves USP34 33 34
  • 84.69 (n)
lizard
(Anolis carolinensis)
Reptilia USP34 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp34 33
  • 79.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24028 33
zebrafish
(Danio rerio)
Actinopterygii usp34 33 34
  • 71.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5794 33 34
  • 52.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003643 33
  • 51.86 (n)
worm
(Caenorhabditis elegans)
Secernentea T24B8.7 34
  • 16 (a)
OneToMany
Species where no ortholog for USP34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP34 Gene

ENSEMBL:
Gene Tree for USP34 (if available)
TreeFam:
Gene Tree for USP34 (if available)

Paralogs for USP34 Gene

Paralogs for USP34 Gene

Pseudogenes.org Pseudogenes for USP34 Gene

genes like me logo Genes that share paralogs with USP34: view

Variants for USP34 Gene

Sequence variations from dbSNP and Humsavar for USP34 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000004546 -- 61,443,881(-) A/C intron_variant
rs1000006832 -- 61,343,264(-) C/G intron_variant
rs1000034464 -- 61,276,134(-) T/C intron_variant
rs1000037184 -- 61,257,824(-) G/A intron_variant
rs1000042820 -- 61,205,543(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USP34 Gene

Variant ID Type Subtype PubMed ID
nsv961408 CNV duplication 23825009
nsv7313 OTHER inversion 18451855
nsv582119 CNV loss 21841781
nsv582118 CNV gain 21841781
nsv528479 CNV loss 19592680
nsv1129395 OTHER inversion 24896259
nsv1014905 CNV gain 25217958
nsv1012689 CNV gain 25217958
esv3591018 CNV loss 21293372
esv3591017 CNV loss 21293372
esv3591016 CNV loss 21293372
esv3583846 CNV loss 25503493
esv3583843 CNV loss 25503493
esv3583842 CNV loss 25503493
esv3396738 CNV insertion 20981092
esv2760616 CNV loss 21179565
esv2666095 CNV deletion 23128226
dgv1126e212 CNV loss 25503493

Variation tolerance for USP34 Gene

Residual Variation Intolerance Score: 0.0422% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP34 Gene

Human Gene Mutation Database (HGMD)
USP34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP34 Gene

Disorders for USP34 Gene

Additional Disease Information for USP34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for USP34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP34 Gene

Publications for USP34 Gene

  1. The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling. (PMID: 21383061) Lui TT … Angers S (Molecular and cellular biology 2011) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for USP34 Gene

Sources for USP34 Gene

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