Aliases for USP32 Gene

Aliases for USP32 Gene

  • Ubiquitin Specific Peptidase 32 2 3 5
  • USP10 2 3 4
  • Ubiquitin-Specific-Processing Protease 32 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 32 3 4
  • Renal Carcinoma Antigen NY-REN-60 3 4
  • Ubiquitin Specific Protease 32 2 3
  • Deubiquitinating Enzyme 32 3 4
  • Ubiquitin Thioesterase 32 3 4
  • NY-REN-60 2 3
  • Ubiquitin Thiolesterase 32 3
  • EC 4
  • EC 51
  • USP32 5

External Ids for USP32 Gene

Previous GeneCards Identifiers for USP32 Gene

  • GC17M058596
  • GC17M058730
  • GC17M058729
  • GC17M055609
  • GC17M058254
  • GC17M053625

Summaries for USP32 Gene

GeneCards Summary for USP32 Gene

USP32 (Ubiquitin Specific Peptidase 32) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP6.

Additional gene information for USP32 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP32 Gene

Genomics for USP32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J060387 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 618.5 +31.3 31298 6.5 HNRNPL PRDM10 REST ZNF629 TFE3 RFX1 LEF1 IKZF1 NFKBIZ KDM1A USP32 C17orf64 NDUFB8P2 PPM1D TUBD1 HEATR6 RPL32P32 RPS6KB1 CA4 ENSG00000275860
GH17J060420 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.9 869 2 HNRNPL CTCF BACH1 LARP7 ZNF143 POLR2A TRIM22 RAD21 DPF2 RUNX3 C17orf64 USP32 LOC105371850
GH17J060423 Enhancer 0.5 Ensembl 600.7 -1.6 -1631 1.4 KLF9 ZNF766 ZNF316 ZSCAN5C NFXL1 KLF10 KLF1 USP32 C17orf64 HMGN2P42 APPBP2
GH17J060149 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl 18.6 +271.7 271705 1.9 KDM1A EZH2 HES1 ZBTB26 NFXL1 WT1 CTCF SAFB ZNF202 REST CA4 VMP1 USP32 TUBD1 PPM1D HEATR6 RPS6KB1 SMG8 NDUFB8P2 RPL32P32
GH17J060161 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 17.8 +260.7 260673 1.5 PRDM10 RFX1 ZIC2 ZSCAN4 PKNOX1 PATZ1 ZNF600 ZNF341 RELA RFX3 VMP1 USP32 CA4 HEATR6 PPM1D lnc-CA4-2 C17orf64
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP32

Top Transcription factor binding sites by QIAGEN in the USP32 gene promoter:
  • FAC1
  • FOXD1
  • FOXJ2
  • FOXJ2 (long isoform)
  • LCR-F1
  • Lmo2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • RSRFC4

Genomic Locations for USP32 Gene

Genomic Locations for USP32 Gene
245,240 bases
Minus strand
245,141 bases
Minus strand

Genomic View for USP32 Gene

Genes around USP32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP32 Gene

Proteins for USP32 Gene

  • Protein details for USP32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 32
    Protein Accession:
    Secondary Accessions:
    • Q7Z5T3
    • Q9BX85
    • Q9Y591

    Protein attributes for USP32 Gene

    1604 amino acids
    Molecular mass:
    181656 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP32 Gene


neXtProt entry for USP32 Gene

Selected DME Specific Peptides for USP32 Gene


Post-translational modifications for USP32 Gene

  • Ubiquitination at Lys951
  • Modification sites at PhosphoSitePlus

Domains & Families for USP32 Gene

Gene Families for USP32 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP32 Gene

  • Ubiquitin thiolesterase, family 2
  • Ubiquitin-specific protease DUSP
  • Ubiquitin carboxyl-terminal hydrolase, N-terminal region 2

Suggested Antigen Peptide Sequences for USP32 Gene

GenScript: Design optimal peptide antigens:
  • USP32 protein (Q4VC15_HUMAN)
  • USP32 protein (Q6IRT0_HUMAN)
  • Ubiquitin-specific-processing protease 32 (UBP32_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP32: view

Function for USP32 Gene

Molecular function for USP32 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=; Evidence={ECO:0000269|PubMed:20549504};.

Enzyme Numbers (IUBMB) for USP32 Gene

Gene Ontology (GO) - Molecular Function for USP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA,IDA 20549504
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24705354
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP32: view
genes like me logo Genes that share phenotypes with USP32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USP32

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP32

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP32 Gene

Localization for USP32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP32 Gene

Membrane. Lipid-anchor. Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP32 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA,IDA 20549504
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with USP32: view

Pathways & Interactions for USP32 Gene

PathCards logo

SuperPathways for USP32 Gene

SuperPathway Contained pathways
1 Ubiquitin-Proteasome Dependent Proteolysis
genes like me logo Genes that share pathways with USP32: view

Pathways by source for USP32 Gene

1 Qiagen pathway for USP32 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis

Gene Ontology (GO) - Biological Process for USP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination TAS 20549504
genes like me logo Genes that share ontologies with USP32: view

No data available for SIGNOR curated interactions for USP32 Gene

Drugs & Compounds for USP32 Gene

(1) Drugs for USP32 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP32: view

Transcripts for USP32 Gene

mRNA/cDNA for USP32 Gene

9 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP32

Alternative Splicing Database (ASD) splice patterns (SP) for USP32 Gene

No ASD Table

Relevant External Links for USP32 Gene

GeneLoc Exon Structure for

Expression for USP32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP32 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for USP32 Gene

This gene is overexpressed in Testis (32.4), Lung (21.8), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP32 Gene

Protein tissue co-expression partners for USP32 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP32

SOURCE GeneReport for Unigene cluster for USP32 Gene:


Evidence on tissue expression from TISSUES for USP32 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with USP32: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP32 Gene

Orthologs for USP32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP32 31
  • 100 (a)
(Canis familiaris)
Mammalia -- 31
  • 94 (a)
USP32 30
  • 93.37 (n)
(Bos Taurus)
Mammalia -- 31
  • 93 (a)
USP32 30
  • 91.19 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
(Mus musculus)
Mammalia Usp32 30 17 31
  • 91.06 (n)
(Rattus norvegicus)
Mammalia Usp32 30
  • 90.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 90 (a)
(Gallus gallus)
Aves -- 31
  • 83 (a)
USP32 30
  • 80 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 77 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia usp32 30
  • 75.69 (n)
(Danio rerio)
Actinopterygii usp32 30 31
  • 69.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001209 30
  • 52.8 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8334 30 31
  • 52.34 (n)
(Caenorhabditis elegans)
Secernentea cyk-3 30
  • 45.87 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 31
  • 20 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
Species where no ortholog for USP32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for USP32 Gene

Gene Tree for USP32 (if available)
Gene Tree for USP32 (if available)
Evolutionary constrained regions (ECRs) for USP32: view image

Paralogs for USP32 Gene

(9) SIMAP similar genes for USP32 Gene using alignment to 12 proteins:

  • K7EL53_HUMAN
  • K7EN13_HUMAN
  • Q4VC15_HUMAN
  • Q7Z5T3_HUMAN Pseudogenes for USP32 Gene

genes like me logo Genes that share paralogs with USP32: view

Variants for USP32 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP32 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1053621 - p.Gly1568Arg
rs1053625 - p.Thr1578Ile
rs3207630 - p.Ala1469Gly
rs7208980 - p.His76Tyr

Additional dbSNP identifiers (rs#s) for USP32 Gene

Structural Variations from Database of Genomic Variants (DGV) for USP32 Gene

Variant ID Type Subtype PubMed ID
dgv3273n100 CNV gain 25217958
dgv535n67 CNV gain 20364138
dgv559e199 CNV deletion 23128226
dgv5734n54 CNV loss 21841781
dgv5735n54 CNV loss 21841781
dgv5736n54 CNV loss 21841781
dgv5737n54 CNV loss 21841781
esv2085161 CNV deletion 18987734
esv22599 CNV gain+loss 19812545
esv2438168 CNV deletion 19546169
esv24610 CNV gain+loss 19812545
esv2478804 CNV deletion 19546169
esv2667558 CNV deletion 23128226
esv2716087 CNV deletion 23290073
esv2716088 CNV deletion 23290073
esv2716089 CNV deletion 23290073
esv2716090 CNV deletion 23290073
esv3334367 CNV duplication 20981092
esv3554617 CNV deletion 23714750
esv3640923 CNV loss 21293372
esv3893033 CNV loss 25118596
nsv1063670 CNV loss 25217958
nsv1071394 CNV deletion 25765185
nsv1125639 CNV tandem duplication 24896259
nsv1134661 CNV deletion 24896259
nsv1134663 CNV deletion 24896259
nsv507850 OTHER sequence alteration 20534489
nsv519929 CNV loss 19592680
nsv575806 CNV loss 21841781
nsv575810 CNV loss 21841781
nsv820574 CNV deletion 20802225
nsv820735 CNV duplication 20802225
nsv828078 CNV loss 20364138
nsv828079 CNV loss 20364138
nsv833504 CNV gain 17160897
nsv9581 CNV loss 18304495
nsv960131 CNV duplication 23825009
nsv960514 CNV duplication 23825009
nsv962351 CNV duplication 23825009
nsv962352 CNV duplication 23825009
nsv962354 CNV duplication 23825009

Variation tolerance for USP32 Gene

Residual Variation Intolerance Score: 5.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP32 Gene

Disorders for USP32 Gene

Additional Disease Information for USP32

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for USP32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP32 Gene

Publications for USP32 Gene

  1. The Tre2 (USP6) oncogene is a hominoid-specific gene. (PMID: 12604796) Paulding CA … Haber DA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers. (PMID: 20549504) Akhavantabasi S … Erson AE (Mammalian genome : official journal of the International Mammalian Genome Society 2010) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3

Products for USP32 Gene

  • Signalway Proteins for USP32

Sources for USP32 Gene