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Aliases for USP29 Gene

Aliases for USP29 Gene

  • Ubiquitin Specific Peptidase 29 2 3 5
  • Ubiquitin-Specific-Processing Protease 29 3 4
  • Deubiquitinating Enzyme 29 3 4
  • Ubiquitin Thioesterase 29 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 29 3
  • Ubiquitin-Specific Processing Protease 3
  • Ubiquitin Specific Protease 29 2
  • Ubiquitin Thiolesterase 29 3
  • HOM-TES-84/86 3
  • EC 4
  • EC 56

External Ids for USP29 Gene

Previous GeneCards Identifiers for USP29 Gene

  • GC19P058538
  • GC19P058094
  • GC19P062316
  • GC19P062331
  • GC19P057631
  • GC19P053944

Summaries for USP29 Gene

GeneCards Summary for USP29 Gene

USP29 (Ubiquitin Specific Peptidase 29) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP37.

Additional gene information for USP29 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP29 Gene

Genomics for USP29 Gene

GeneHancer (GH) Regulatory Elements for USP29 Gene

Promoters and enhancers for USP29 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057119 Promoter 0.6 EPDnew 550.8 +0.8 828 0.1 GABPB1 USP29 GC19M057135 GC19M057103
GH19I057319 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.3 +201.7 201667 2.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 ZNF543 ZNF805 ZNF548 ZNF304 ZNF586 ZNF264 ZNF274 ZNF587B TRAPPC2B ZNF547
GH19I056972 Enhancer 1.1 ENCODE dbSUPER 11.1 -143.3 -143287 7.6 FOXA2 MLX ZFP64 ARID4B ZNF48 ETS1 RXRA SP5 NFYC ZHX2 USP29 ENSG00000269786 GC19P057027
GH19I056983 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 9.1 -135.5 -135496 0.7 ZNF146 ZNF280D RFX1 RFX3 AURKC USP29 ZNF471 ZNF835 ZNF772 GC19P057027 ENSG00000269786
GH19I057095 Enhancer 0.6 ENCODE 12 -22.2 -22190 2.5 SOX13 GATAD2A TFAP4 FOXA2 SAP130 TEAD1 FOXA3 KAT8 TEAD3 TGIF2 USP29 ZIM3 ZIM2 PEG3 AURKC ZNF805 ZNF418 ZNF814 ZNF417 LOC100128398
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP29 gene promoter:

Genomic Locations for USP29 Gene

Genomic Locations for USP29 Gene
12,789 bases
Plus strand

Genomic View for USP29 Gene

Genes around USP29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP29 Gene

Proteins for USP29 Gene

  • Protein details for USP29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 29
    Protein Accession:

    Protein attributes for USP29 Gene

    922 amino acids
    Molecular mass:
    104156 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP29 Gene

Selected DME Specific Peptides for USP29 Gene


Post-translational modifications for USP29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP29 Gene

Domains & Families for USP29 Gene

Gene Families for USP29 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP29 Gene

Suggested Antigen Peptide Sequences for USP29 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP29: view

Function for USP29 Gene

Molecular function for USP29 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP29 Gene

Gene Ontology (GO) - Molecular Function for USP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS 10958632
genes like me logo Genes that share ontologies with USP29: view

Phenotypes for USP29 Gene

genes like me logo Genes that share phenotypes with USP29: view

miRNA for USP29 Gene

miRTarBase miRNAs that target USP29

Clone Products

  • Addgene plasmids for USP29

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP29 Gene

Localization for USP29 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP29 gene
Compartment Confidence
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for USP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with USP29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for USP29 Gene

Pathways & Interactions for USP29 Gene

genes like me logo Genes that share pathways with USP29: view

Pathways by source for USP29 Gene

1 Qiagen pathway for USP29 Gene

Gene Ontology (GO) - Biological Process for USP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP29: view

No data available for SIGNOR curated interactions for USP29 Gene

Drugs & Compounds for USP29 Gene

(1) Drugs for USP29 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP29: view

Transcripts for USP29 Gene

mRNA/cDNA for USP29 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP29 Gene

Ubiquitin specific peptidase 29:
Representative Sequences:

Clone Products

  • Addgene plasmids for USP29

Alternative Splicing Database (ASD) splice patterns (SP) for USP29 Gene

No ASD Table

Relevant External Links for USP29 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP29 Gene

This gene is overexpressed in Testis (x49.0).

Protein differential expression in normal tissues from HIPED for USP29 Gene

This gene is overexpressed in Cerebrospinal fluid (32.0), Heart (16.3), Cervix (11.0), and Esophagus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP29 Gene

Protein tissue co-expression partners for USP29 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP29 Gene:


SOURCE GeneReport for Unigene cluster for USP29 Gene:

genes like me logo Genes that share expression patterns with USP29: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP29 Gene

Orthologs for USP29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP29 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP29 33
  • 98.92 (n)
(Mus musculus)
Mammalia Usp29 33 16 34
  • 64.65 (n)
(Rattus norvegicus)
Mammalia Usp29 33
  • 63.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
(Danio rerio)
Actinopterygii USP29 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2829 34
  • 25 (a)
Species where no ortholog for USP29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP29 Gene

Gene Tree for USP29 (if available)
Gene Tree for USP29 (if available)

Paralogs for USP29 Gene

Paralogs for USP29 Gene

(2) SIMAP similar genes for USP29 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with USP29: view

Variants for USP29 Gene

Sequence variations from dbSNP and Humsavar for USP29 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000838162 -- 57,126,027(+) A/C intron_variant
rs1000842628 -- 57,127,069(+) G/T intron_variant
rs1000849117 -- 57,131,217(+) T/A coding_sequence_variant, missense_variant
rs1001220970 -- 57,130,703(+) G/A coding_sequence_variant, synonymous_variant
rs1001421708 -- 57,119,025(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for USP29 Gene

Variant ID Type Subtype PubMed ID
esv3644892 CNV gain 21293372
esv3893256 CNV loss 25118596
nsv1062392 CNV gain 25217958

Variation tolerance for USP29 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP29 Gene

Disorders for USP29 Gene

Additional Disease Information for USP29

No disorders were found for USP29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP29 Gene

Publications for USP29 Gene

  1. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. (PMID: 10958632) Kim J … Stubbs L (Genome research 2000) 3 4 22 58
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 58
  3. USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination. (PMID: 24632611) Martín Y … Freire R (Oncogene 2015) 3 58
  4. JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. (PMID: 21285945) Liu J … Levens D (The EMBO journal 2011) 3 58
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa ME … Harper JW (Cell 2009) 3 58

Products for USP29 Gene

  • Addgene plasmids for USP29

Sources for USP29 Gene

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