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The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
USP28 (Ubiquitin Specific Peptidase 28) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP25.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IEA,IMP | 16901786 |
GO:0005515 | protein binding | IEA,IPI | 16901786 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0016604 | nuclear body | IDA | -- |
GO:0032991 | protein-containing complex | IDA | 17873522 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Deubiquitination |
.74
|
|
2 | Metabolism of proteins | ||
3 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000077 | DNA damage checkpoint | IBA,IMP | 18662541 |
GO:0006281 | DNA repair | IEA | -- |
GO:0006508 | proteolysis | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IEA,IDA | 17873522 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Water | Approved | Pharma | 0 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | |||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||
SP5: | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | USP28 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | USP28 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | USP28 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Usp28 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Usp28 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | USP28 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | USP28 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | USP28 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | USP28 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp28 30 |
|
||
Str.12044 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | usp28 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | K02C4.3 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP2 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17115997 | Benign: not provided | 113,801,625(-) |
T/A NM_020886.4(USP28):c.2916A>T (p.Val972=) |
SYNONYMOUS | |
rs193920846 | Uncertain Significance: Malignant tumor of prostate | 113,834,299(-) |
G/A NM_020886.4(USP28):c.571C>T (p.Leu191Phe) |
MISSENSE_VARIANT,FIVE_PRIME_UTR |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761711 | CNV | gain | 21179565 |
esv3627781 | CNV | loss | 21293372 |
nsv497 | CNV | insertion | 18451855 |
nsv832273 | CNV | loss | 17160897 |
No disorders were found for USP28 Gene.