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The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016] See more...
Aliases for USP28 Gene
Aliases for USP28 Gene
External Ids for USP28 Gene
- HGNC: 12625
- NCBI Entrez Gene: 57646
- Ensembl: ENSG00000048028
- OMIM®: 610748
- UniProtKB/Swiss-Prot: Q96RU2
Previous GeneCards Identifiers for USP28 Gene
- GC11M116021
- GC11M115180
- GC11M113702
- GC11M113206
- GC11M113173
- GC11M109597
- GC11M113668
Summaries for USP28 Gene
-
The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
GeneCards Summary for USP28 Gene
USP28 (Ubiquitin Specific Peptidase 28) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP25.
UniProtKB/Swiss-Prot Summary for USP28 Gene
-
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).
Additional gene information for USP28 Gene
- HGNC (12625)
- NCBI Entrez Gene (57646)
- Ensembl (ENSG00000048028)
- OMIM® (610748)
- UniProtKB/Swiss-Prot (Q96RU2)
- Open Targets Platform(ENSG00000048028)
- Monarch Initiative
- Search for USP28 at DataMed
- Search for USP28 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP28 Gene
Genomics for USP28 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for USP28 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around USP28 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP28
- Top Transcription factor binding sites by QIAGEN in the USP28 gene promoter:
-
- c-Myc
- GATA-1
- LCR-F1
- Max1
- N-Myc
- Nkx2-5
- p53
- S8
- USF-1
- USF1
Genomic Locations for USP28 Gene
Latest Assembly
- chr11:113,797,874-113,875,572
- (GRCh38/hg38)
- Size:
- 77,699 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:113,668,597-113,746,294
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 77,698 bases
- Orientation:
- Minus strand
- chr11:113,668,596-113,746,292
- (GRCh37/hg19 by Ensembl)
- Size:
- 77,697 bases
- Orientation:
- Minus strand
Genomic View for USP28 Gene
Genes around USP28 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2 by HGNC
- 11q23.2 by Entrez Gene
- 11q23.2 by Ensembl
USP28 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for USP28 Gene
Proteins for USP28 Gene
-
Protein details for USP28 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RU2-UBP28_HUMAN
- Recommended name:
- Ubiquitin carboxyl-terminal hydrolase 28
- Protein Accession:
- Q96RU2
- B0YJC0
- B0YJC1
- Q6NZX9
- Q9P213
Protein attributes for USP28 Gene
- Size:
- 1077 amino acids
- Molecular mass:
- 122491 Da
- Quaternary structure:
-
- Interacts with ZNF304 (PubMed:24623306). Interacts with PRKD1 (PubMed:24623306). Interacts with TP53BP1 (PubMed:16901786). Interacts with isoform 1 of FBXW7; following DNA damage, dissociates from FBXW7 leading to degradation of MYC (PubMed:17873522, PubMed:17558397).
Three dimensional structures from OCA and Proteopedia for USP28 Gene
Protein Expression for USP28 Gene
Selected DME Specific Peptides for USP28 Gene
- Q96RU2:
-
- LQYLFAL
- QQQDVSEFTHKLLDWLEDAFQ
- LHAVLVH
- FGQYPLQVNG
- LPPVLTFELSRFEFNQ
Post-translational modifications for USP28 Gene
- Degraded upon nickel ion level or hypoxia exposure.
- Phosphorylated upon DNA damage at Ser-67 and Ser-714, by ATM or ATR (PubMed:16901786). Phosphorylated by PRKD1 (PubMed:24623306).
-
Ubiquitination at Lys243
- NX_Q96RU2 (NX_Q96RU2-1)
- Modification sites at PhosphoSitePlus
Other Protein References for USP28 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001287958.1
- NP_001333181.1
- NP_001333182.1
- NP_001333183.1
- NP_001333184.1
- NP_001333186.1
- NP_001333187.1
- NP_001333188.1
- NP_001333189.1
- NP_001333190.1
- NP_001333191.1
- NP_001333192.1
- NP_001333193.1
- NP_001333194.1
- NP_001333196.1
- NP_001333197.1
- NP_001333198.1
- NP_001333199.1
- NP_001333200.1
- NP_001333201.1
- NP_001333202.1
- NP_065937.1
Antibodies for research
- LifeSpan BioSciences USP28 Antibody
-
Custom Antibody ServicesOriGene Antibodies for USP28
- Novus Biologicals Antibodies for USP28
-
Abcam antibodies for USP28
- Invitrogen Antibodies for USP28 (AFLGC-USP28)
- Sino Biological Antibodies for USP28
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for USP28
- Origene Custom Protein Services for USP28
- antibodies-online: Show 4 available USP28 Proteins ranked by validation data
- Compare Top USP28 Proteins
-
Quality Products:
-
Abcam proteins for USP28
Assay products for research
Domains & Families for USP28 Gene
Gene Families for USP28 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for USP28 Gene
- InterPro:
- Blocks:
-
- Ubiquitin interacting motif
- Ubiquitin thiolesterase, family 2
- ProtoNet:
Suggested Antigen Peptide Sequences for USP28 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin carboxyl-terminal hydrolase (B4E3L3_HUMAN)
- Ubiquitin-specific-processing protease 28 (UBP28_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96RU2- Family:
-
- Belongs to the peptidase C19 family. USP28 subfamily.
Function for USP28 Gene
Molecular function for USP28 Gene
- UniProtKB/Swiss-Prot Function:
- Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated upon hypoxia (PubMed:20046830). Up-regulated by the transcription factor c-Jun/JUN in a KRAS-dependent manner in colorectal cancer (CRC) cells (PubMed:24623306).
Enzyme Numbers (IUBMB) for USP28 Gene
Phenotypes From GWAS Catalog for USP28 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IEA,IMP | 16901786 |
| GO:0005515 | protein binding | IEA,IPI | 16901786 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008234 | cysteine-type peptidase activity | IEA | -- |
Phenotypes for USP28 Gene
- MGI mutant phenotypes for USP28:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for USP28:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability in esophageal squamous lineage; decreased viability in glioblastoma multiforme (GBM) lineage
- Increased viability with nutlin-3
Animal Models for research
-
Taconic Biosciences Mouse Models for USP28
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for USP28 - Starting at $85 >
- * USP28 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for USP28
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP28
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP28
miRNA for USP28 Gene
- miRTarBase miRNAs that target USP28
-
- hsa-miR-122-5p (MIRT023273)
- hsa-miR-181a-5p (MIRT025164)
- hsa-miR-1301-3p (MIRT036013)
- hsa-miR-615-3p (MIRT039972)
- hsa-miR-221-3p (MIRT046845)
- hsa-miR-363-3p (MIRT053200)
- hsa-miR-340-5p (MIRT058232)
- hsa-miR-25-3p (MIRT178953)
- hsa-miR-32-5p (MIRT178954)
- hsa-miR-92a-3p (MIRT178955)
- hsa-miR-367-3p (MIRT178956)
- hsa-miR-92b-3p (MIRT178957)
- hsa-miR-3163 (MIRT178958)
- hsa-miR-5003-3p (MIRT178960)
- hsa-miR-20a-5p (MIRT439332)
- hsa-miR-106b-5p (MIRT439334)
- hsa-miR-5589-3p (MIRT553042)
- hsa-miR-20a-3p (MIRT553043)
- hsa-miR-4729 (MIRT553044)
- hsa-miR-4668-3p (MIRT553045)
- hsa-miR-137 (MIRT553046)
- hsa-miR-153-3p (MIRT553047)
- hsa-miR-519d-3p (MIRT726167)
- hsa-miR-20b-5p (MIRT726168)
- hsa-miR-93-5p (MIRT726169)
- hsa-miR-17-5p (MIRT726170)
- hsa-miR-3940-5p (MIRT733410)
- hsa-let-7a-2-3p (MIRT783020)
- hsa-let-7c-3p (MIRT783029)
- hsa-let-7g-3p (MIRT783038)
- hsa-miR-129-5p (MIRT783633)
- hsa-miR-493-5p (MIRT786906)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP28
- Browse OriGene Inhibitory RNA Products For USP28
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP28
Clone products for research
- Applied Biological Materials (abm): Clones for USP28 - Starting at $45 >
- * USP28 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for USP28
- Addgene plasmids for USP28
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP28
Cell Lines for research
-
Horizon Cell Lines for USP28
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP28 Gene
Localization for USP28 Gene
Subcellular locations from UniProtKB/Swiss-Prot for USP28 Gene
- Nucleus, nucleoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IBA | 21873635 |
| GO:0016604 | nuclear body | IDA | -- |
| GO:0032991 | protein-containing complex | IDA | 17873522 |
Pathways & Interactions for USP28 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Deubiquitination |
.74
|
|
| 2 | Metabolism of proteins | ||
| 3 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
-
|
|
Pathways by source for USP28 Gene
4 Reactome pathways for USP28 Gene
1 Qiagen pathway for USP28 Gene
- Ubiquitin-Proteasome Dependent Proteolysis
Interacting Proteins for USP28 Gene
Selected Interacting proteins:
Q96RU2-UBP28_HUMAN
ENSP00000003302
for USP28 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for USP28
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IBA,IMP | 18662541 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA,IDA | 17873522 |
Drugs & Compounds for USP28 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 |
Transcripts for USP28 Gene
mRNA/cDNA for USP28 Gene
- 22 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000003302 4669 nts (view in UCSC)
- ENST00000535607 683 nts (view in UCSC)
- ENST00000537490 567 nts (view in UCSC)
- ENST00000537642 732 nts (view in UCSC)
- ENST00000537706 1900 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for USP28 - Starting at $85 >
- * USP28 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for USP28
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP28
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP28
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP28
- Browse OriGene Inhibitory RNA Products For USP28
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP28
Clone products for research
- Applied Biological Materials (abm): Clones for USP28 - Starting at $45 >
- * USP28 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for USP28
- Addgene plasmids for USP28
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP28
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: |
Relevant External Links for USP28 Gene
- GeneLoc Exon Structure for
- USP28
Expression for USP28 Gene
mRNA differential expression in normal tissues according to GTEx for USP28 Gene
This gene is overexpressed in Heart - Left Ventricle (x5.6), Muscle - Skeletal (x5.0), and Heart - Atrial Appendage (x4.1).
This gene is overexpressed in Bone (35.2) and Fetal heart (14.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP28 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP28
SOURCE GeneReport for Unigene cluster for USP28 Gene:
Hs.503891Evidence on tissue expression from TISSUES for USP28 Gene
- Nervous system(4.4)
- Liver(4.4)
- Eye(4.1)
- Heart(2.5)
- Muscle(2.5)
- Intestine(2.2)
- Lymph node(2.2)
- Stomach(2.1)
- Kidney(2.1)
Primer products for research
-
OriGene qPCR primer pairs for USP28
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP28 Gene
Orthologs for USP28 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | USP28 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | USP28 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | USP28 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Usp28 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Usp28 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | USP28 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | USP28 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | USP28 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | USP28 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp28 30 |
|
||
| Str.12044 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | usp28 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | K02C4.3 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP2 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for USP28 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for USP28 Gene
- ENSEMBL:
- Gene Tree for USP28 (if available)
- TreeFam:
- Gene Tree for USP28 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for USP28: view image
Paralogs for USP28 Gene
Paralogs for USP28 Gene
- USP25 5
- USP47 5
- USP48 5
- USP7 5
- USP38 5
- USP42 5
- USP31 5
- USP34 5
- USP19 5
- USP20 5
- USP33 5
- USP35 5
- USP36 5
- USP17L11 5
- USP17L12 5
- USP17L13 5
- USP17L15 5
- USP17L17 5
- USP17L18 5
- USP17L19 5
- USP17L20 5
- USP17L21 5
- USP17L22 5
- USP17L24 5
- USP17L25 5
- USP17L26 5
- USP17L5 5
- USP17L27 5
- USP17L28 5
- USP17L29 5
- USP17L30 5
- USP43 5
- USP49 5
- USP8 5
- USP24 5
- USP15 5
- USP44 5
- USP32 5
- USP40 5
- USP9Y 5
- USP16 5
- USP17L1 5
- USP17L4 5
- USP17L8 5
- USP17L3 5
- USP9X 5
- USP17L2 5
- USP11 5
- USP17L10 5
- USP6 5
- USP4 5
- USP1 5
- USP2 5
- USP14 5
- USP17L7 5
- USP51 5
- USP5 5
- USP26 5
- USP22 5
- USP3 5
- USP45 5
- USP30 5
- USP13 5
- USP37 5
- USP21 5
- USP18 5
- USP27X 5
- USP50 5
- USP10 5
- USP29 5
- USP41 5
- USP17L23 5
(1) SIMAP similar genes for USP28 Gene using alignment to 14 proteins:
- UBP28_HUMAN
- B4E3L3_HUMAN
- F5GZ74_HUMAN
- F5H2G4_HUMAN
- F5H6Q3_HUMAN
- G3V1N5_HUMAN
- H0YFA0_HUMAN
- H0YFD7_HUMAN
- H0YFT9_HUMAN
- H0YFX3_HUMAN
- H0YG96_HUMAN
- H0YH19_HUMAN
- L8EA89_HUMAN
- Q6NZX9_HUMAN
Variants for USP28 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP28 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17115997 | Benign: not provided | 113,801,625(-) |
T/A NM_020886.4(USP28):c.2916A>T (p.Val972=) |
SYNONYMOUS | |
| rs193920846 | Uncertain Significance: Malignant tumor of prostate | 113,834,299(-) |
G/A NM_020886.4(USP28):c.571C>T (p.Leu191Phe) |
MISSENSE_VARIANT,FIVE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761711 | CNV | gain | 21179565 |
| esv3627781 | CNV | loss | 21293372 |
| nsv497 | CNV | insertion | 18451855 |
| nsv832273 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
3.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.89;
35.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for USP28 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- USP28
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP28 Gene
Disorders for USP28 Gene
Additional Disease Information for USP28
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for USP28 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP28 Gene
Publications for USP28 Gene
- Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. (PMID: 11597335) Valero R … Marfany G (Genome biology 2001) 2 3 4 23
- A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. (PMID: 24623306) Serra RW … Green MR (eLife 2014) 3 4
- The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PMID: 18662541) Bassermann F … Pagano M (Cell 2008) 3 4
- Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. (PMID: 17873522) Popov N … Eilers M (Cell cycle (Georgetown, Tex.) 2007) 3 4
- The ubiquitin-specific protease USP28 is required for MYC stability. (PMID: 17558397) Popov N … Eilers M (Nature cell biology 2007) 3 4
ExternalLinks
Products for USP28 Gene
- Custom Antibody ServicesOriGene Antibodies for USP28
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for USP28
- Origene Custom Protein Services for USP28
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP28
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- OriGene qPCR primer pairs for USP28
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For USP28
- Sino Biological Human cDNA Clone for USP28
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for USP28
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for USP28
- Browse Antibodies
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- Taconic Biosciences Mouse Models for USP28
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for USP28 (AFLGC-USP28)
- VectorBuilder Custom and pre-made DNA vectors for USP28 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for USP28 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for USP28 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for USP28 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for USP28
- Addgene plasmids for USP28
- antibodies-online: Show 26 available USP28 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Search results for available USP28 related products ranked by validation data
- antibodies-online: Show 4 available USP28 Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for USP28
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP28
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP28
- Search GeneCopoeia for miRNA 3'UTR Target clone products for USP28
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP28
Sources for USP28 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB