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The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
USP28 (Ubiquitin Specific Peptidase 28) is a Protein Coding gene. Diseases associated with USP28 include Iodine Hypothyroidism and Toxic Diffuse Goiter. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP25.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IBA,IDA | 16901786 |
GO:0005515 | protein binding | IEA,IPI | 16901786 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0016604 | nuclear body | IDA | -- |
GO:0032991 | protein-containing complex | IDA | 17873522 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Deubiquitination |
.74
|
|
2 | Metabolism of proteins | ||
3 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000077 | DNA damage checkpoint | IMP | 18662541 |
GO:0006281 | DNA repair | IEA | -- |
GO:0006508 | proteolysis | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IEA,IDA | 17873522 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Water | Approved | Pharma | 0 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | |||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||
SP5: | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | USP28 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | USP28 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | USP28 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Usp28 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Usp28 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | USP28 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | USP28 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | USP28 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | USP28 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp28 30 |
|
||
Str.12044 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | usp28 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | K02C4.3 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP2 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
786926 | Benign: not provided | 113,801,625(-) | T/A | SYNONYMOUS_VARIANT | |
rs193920846 | Uncertain Significance: Malignant tumor of prostate | 113,834,299(-) | G/A | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761711 | CNV | gain | 21179565 |
esv3627781 | CNV | loss | 21293372 |
nsv497 | CNV | insertion | 18451855 |
nsv832273 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
iodine hypothyroidism |
|
|
toxic diffuse goiter |
|
|
hirata disease |
|
|
colorectal cancer |
|
|