Aliases for USP27X Gene
External Ids for USP27X Gene
Previous GeneCards Identifiers for USP27X Gene
This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016]
GeneCards Summary for USP27X Gene
USP27X (Ubiquitin Specific Peptidase 27, X-Linked) is a Protein Coding gene. Diseases associated with USP27X include Mental Retardation, X-Linked 105 and X-Linked Non-Specific Intellectual Disability. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP22.
UniProtKB/Swiss-Prot for USP27X Gene
Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity.