Aliases for USP26 Gene
External Ids for USP26 Gene
Previous GeneCards Identifiers for USP26 Gene
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]
GeneCards Summary for USP26 Gene
USP26 (Ubiquitin Specific Peptidase 26) is a Protein Coding gene. Diseases associated with USP26 include Male Infertility and Azoospermia. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP29.
UniProtKB/Swiss-Prot Summary for USP26 Gene
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.