This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008] See more...

Aliases for USP26 Gene

Aliases for USP26 Gene

  • Ubiquitin Specific Peptidase 26 2 3 5
  • Ubiquitin Carboxyl-Terminal Hydrolase 26 3 4
  • Ubiquitin Specific Protease 26 2 3
  • Deubiquitinating Enzyme 26 3 4
  • Ubiquitin Thioesterase 26 3 4
  • Ubiquitin-Specific Processing Protease 26 3
  • Ubiquitin-Specific-Processing Protease 26 4
  • Ubiquitin Thiolesterase 26 3
  • EC 3.4.19.12 4
  • USP26 5

External Ids for USP26 Gene

Previous GeneCards Identifiers for USP26 Gene

  • GC0XM126805
  • GC0XM129005
  • GC0XM130104
  • GC0XM130865
  • GC0XM131885
  • GC0XM131986
  • GC0XM132158
  • GC0XM121562

Summaries for USP26 Gene

Entrez Gene Summary for USP26 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP26 Gene

USP26 (Ubiquitin Specific Peptidase 26) is a Protein Coding gene. Diseases associated with USP26 include Male Infertility and Azoospermia. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP29.

UniProtKB/Swiss-Prot Summary for USP26 Gene

  • Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

Additional gene information for USP26 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP26 Gene

Genomics for USP26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ132610 Enhancer 0.2 FANTOM5 11.7 +486.3 486323 0.3 USP26 HS6ST2 RF00026-1201 RNU6-98P piR-60146-211 MBNL3
GH0XJ133189 Enhancer 0.2 FANTOM5 10.6 -92.3 -92309 0.2 RF00017-8720 HS6ST2 USP26 GPC4 piR-41306-281 TFDP3
GH0XJ133259 Enhancer 0.2 FANTOM5 4.7 -162.8 -162823 0.2 USP26 RF00003-096 RNU1-115P TFDP3 piR-43106-221 GPC4
GH0XJ133089 Enhancer 0.3 Ensembl 0.4 +6.9 6909 1.2 ZNF121 HS6ST2 LOC107983959 lnc-USP26-1 USP26 piR-50129-293
GH0XJ133172 Enhancer 0.6 Ensembl 0.2 -75.3 -75307 0.9 CTCF PRDM10 ZNF174 RAD21 ELF4 ZBTB11 GABPA SMC3 ELF1 SPI1 HS6ST2 piR-44133-036 piR-41306-281 TFDP3 USP26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP26

Top Transcription factor binding sites by QIAGEN in the USP26 gene promoter:
  • CUTL1
  • ER-alpha
  • FOXF2
  • FOXO1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for USP26 Gene

Genomic Locations for USP26 Gene
chrX:133,024,631-133,097,109
(GRCh38/hg38)
Size:
72,479 bases
Orientation:
Minus strand
chrX:132,158,659-132,231,137
(GRCh37/hg19)
Size:
72,479 bases
Orientation:
Minus strand

Genomic View for USP26 Gene

Genes around USP26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP26 Gene

Proteins for USP26 Gene

  • Protein details for USP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXU7-UBP26_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26
    Protein Accession:
    Q9BXU7
    Secondary Accessions:
    • B9WRT6
    • Q5H9H4

    Protein attributes for USP26 Gene

    Size:
    913 amino acids
    Molecular mass:
    104047 Da
    Quaternary structure:
    • Interacts with AR.

neXtProt entry for USP26 Gene

Post-translational modifications for USP26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP26 Gene

Domains & Families for USP26 Gene

Gene Families for USP26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP26 Gene

InterPro:
Blocks:
  • Ubiquitin thiolesterase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for USP26 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin carboxyl-terminal hydrolase (Q495F8_HUMAN)
  • Ubiquitin-specific-processing protease 26 (UBP26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BXU7

UniProtKB/Swiss-Prot:

UBP26_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP26: view

Function for USP26 Gene

Molecular function for USP26 Gene

UniProtKB/Swiss-Prot Function:
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;.

Enzyme Numbers (IUBMB) for USP26 Gene

Phenotypes From GWAS Catalog for USP26 Gene

Gene Ontology (GO) - Molecular Function for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA 21873635
GO:0005515 protein binding IPI 20501646
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP26: view
genes like me logo Genes that share phenotypes with USP26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP26

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP26 Gene

Localization for USP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP26 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 20501646
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with USP26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for USP26 Gene

Pathways & Interactions for USP26 Gene

PathCards logo

SuperPathways for USP26 Gene

genes like me logo Genes that share pathways with USP26: view

Pathways by source for USP26 Gene

1 Qiagen pathway for USP26 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis

Gene Ontology (GO) - Biological Process for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA 21873635
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IBA,TAS --
genes like me logo Genes that share ontologies with USP26: view

No data available for SIGNOR curated interactions for USP26 Gene

Drugs & Compounds for USP26 Gene

(1) Drugs for USP26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP26: view

Transcripts for USP26 Gene

mRNA/cDNA for USP26 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP26

Alternative Splicing Database (ASD) splice patterns (SP) for USP26 Gene

No ASD Table

Relevant External Links for USP26 Gene

GeneLoc Exon Structure for
USP26

Expression for USP26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP26 Gene

This gene is overexpressed in Testis (x36.3).

Protein differential expression in normal tissues from HIPED for USP26 Gene

This gene is overexpressed in Serum (58.7) and Placenta (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for USP26 Gene



Protein tissue co-expression partners for USP26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP26

SOURCE GeneReport for Unigene cluster for USP26 Gene:

Hs.333137
genes like me logo Genes that share expression patterns with USP26: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP26 Gene

Orthologs for USP26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia USP26 30 31
  • 96.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia USP26 30 31
  • 74.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia USP26 30 31
  • 70.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Usp26 30
  • 61.44 (n)
Mouse
(Mus musculus)
Mammalia Usp26 30 17 31
  • 61.44 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 18 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii USP29 31
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2829 31
  • 25 (a)
OneToMany
Species where no ortholog for USP26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for USP26 Gene

ENSEMBL:
Gene Tree for USP26 (if available)
TreeFam:
Gene Tree for USP26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP26: view image

Paralogs for USP26 Gene

(2) SIMAP similar genes for USP26 Gene using alignment to 2 proteins:

  • UBP26_HUMAN
  • Q495F8_HUMAN

Pseudogenes.org Pseudogenes for USP26 Gene

genes like me logo Genes that share paralogs with USP26: view

Variants for USP26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP26 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
711746 Benign: not provided 133,026,484(-) C/T MISSENSE_VARIANT
717498 Likely Benign: not provided 133,026,245(-) G/A MISSENSE_VARIANT
718406 Benign: not provided 133,027,399(-) G/A SYNONYMOUS_VARIANT
737008 Likely Benign: not provided 133,026,334(-) A/G SYNONYMOUS_VARIANT
761702 Likely Benign: not provided 133,028,070(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for USP26 Gene

Structural Variations from Database of Genomic Variants (DGV) for USP26 Gene

Variant ID Type Subtype PubMed ID
esv3574585 CNV loss 25503493

Variation tolerance for USP26 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP26 Gene

Human Gene Mutation Database (HGMD)
USP26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP26 Gene

Disorders for USP26 Gene

MalaCards: The human disease database

(6) MalaCards diseases for USP26 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
azoospermia
  • spermatogenic failure
infertility
spermatogenic failure, x-linked, 1
  • spgfx1
oligospermia
- elite association - COSMIC cancer census association via MalaCards
Search USP26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with USP26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP26 Gene

Publications for USP26 Gene

  1. USP26 gene variations in fertile and infertile men. (PMID: 18927127) Ribarski I … Kleiman SE (Human reproduction (Oxford, England) 2009) 3 4 23 41
  2. Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls. (PMID: 18377898) Christensen GL … Carrell DT (Fertility and sterility 2008) 3 4 23 41
  3. Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism. (PMID: 15970005) Paduch DA … Schlegel PN (Reproductive biomedicine online 2005) 3 4 23 41
  4. Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. (PMID: 18958354) Lee IW … Teng YN (Asian journal of andrology 2008) 3 23 41
  5. Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility. (PMID: 17968467) Zhang J … Zhang QY (Asian journal of andrology 2007) 3 23 41

Products for USP26 Gene

Sources for USP26 Gene