Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied... See more...

Aliases for USP25 Gene

Aliases for USP25 Gene

  • Ubiquitin Specific Peptidase 25 2 3 5
  • USP21 2 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 25 3 4
  • Deubiquitinating Enzyme 25 3 4
  • Ubiquitin Thioesterase 25 3 4
  • USP On Chromosome 21 3 4
  • Ubiquitin-Specific Processing Protease 25 3
  • Ubiquitin-Specific-Processing Protease 25 4
  • Ubiquitin Specific Protease 25 2
  • Ubiquitin Thiolesterase 25 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 51
  • USP25 5

External Ids for USP25 Gene

Previous GeneCards Identifiers for USP25 Gene

  • GC21P013766
  • GC21P016024
  • GC21P017102
  • GC21P002481

Summaries for USP25 Gene

Entrez Gene Summary for USP25 Gene

  • Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

GeneCards Summary for USP25 Gene

USP25 (Ubiquitin Specific Peptidase 25) is a Protein Coding gene. Diseases associated with USP25 include Arthrogryposis, Renal Dysfunction, And Cholestasis 1 and Arthrogryposis, Renal Dysfunction, And Cholestasis 2. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include peptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP28.

UniProtKB/Swiss-Prot Summary for USP25 Gene

  • Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.
  • The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.

Additional gene information for USP25 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP25 Gene

Genomics for USP25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J015729 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 613.6 +2.9 2867 7.6 HNRNPL PRDM10 RFX1 IKZF1 ZNF692 POLR2A BACH1 JUND LARP7 PRDM1 USP25 lnc-NRIP1-9
GH21J015753 Enhancer 1 FANTOM5 ENCODE 20.2 +23.9 23874 2.7 CREB1 GATAD2A KDM1A JUND POLR2A SP1 ZNF766 NFE2 ZNF316 FOXA2 USP25 RBPMSLP lnc-NRIP1-10 NONHSAG032420.2
GH21J015767 Enhancer 0.8 Ensembl ENCODE 20.3 +42.6 42567 11 ZNF629 SOX13 CEBPB NFE2 TSHZ1 ZNF316 FOXA2 OSR2 MAFF FOS USP25 NONHSAG032420.2 RBPMSLP lnc-NRIP1-10
GH21J015706 Enhancer 0.8 Ensembl ENCODE 20.1 -23.0 -23033 1.4 CREB1 FOXA1 ATF7 SP1 CTBP1 FOS ZNF217 FOSL1 FOSL2 GATA3 SNODB878 piR-57460-418 USP25 lnc-NRIP1-9 NRIP1
GH21J015788 Enhancer 0.7 Ensembl ENCODE 24.1 +59.5 59467 2.4 FOXA1 CEBPB PKNOX1 GATA3 STAT1 JUN NR2C1 USP25 NONHSAG032420.2 lnc-NRIP1-11 lnc-NRIP1-10 RBPMSLP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP25

Top Transcription factor binding sites by QIAGEN in the USP25 gene promoter:
  • AML1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for USP25 Gene

Genomic Locations for USP25 Gene
chr21:15,729,934-15,880,072
(GRCh38/hg38)
Size:
150,139 bases
Orientation:
Plus strand
chr21:17,102,344-17,252,377
(GRCh37/hg19)
Size:
150,034 bases
Orientation:
Plus strand

Genomic View for USP25 Gene

Genes around USP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP25 Gene

Proteins for USP25 Gene

  • Protein details for USP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHP3-UBP25_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 25
    Protein Accession:
    Q9UHP3
    Secondary Accessions:
    • C0LSZ0
    • Q6DHZ9
    • Q9H9W1

    Protein attributes for USP25 Gene

    Size:
    1055 amino acids
    Molecular mass:
    122218 Da
    Quaternary structure:
    • Homodimer or oligomer. Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels.

    Three dimensional structures from OCA and Proteopedia for USP25 Gene

    Alternative splice isoforms for USP25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP25 Gene

Selected DME Specific Peptides for USP25 Gene

Q9UHP3:
  • QQQDVSEFTHKLLDWLEDAFQ
  • LHAVLVH
  • FGQYPLQVNG
  • LPPVLTFELSRFEFNQ

Post-translational modifications for USP25 Gene

  • Acetylated.
  • Sumoylation impairs binding to and hydrolysis of ubiquitin chains. Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP1. Regulated by ubiquitination on the same residue.
  • Preferentially monoubiquitinated but can also be polyubiquitinated. Autodeubiquitinated. Ubiquitination activates the enzymatic activity either by preventing sumoylation or by allowing novel interactions.
  • Phosphorylation in the C-terminal by SYK regulates USP25 cellular levels.
  • Ubiquitination at Lys15, Lys201, Lys250, Lys254, Lys312, Lys313, Lys392, Lys444, Lys520, Lys584, Lys630, Lys698, Lys715, and Lys721
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for USP25
  • Santa Cruz Biotechnology (SCBT) Antibodies for USP25

Domains & Families for USP25 Gene

Gene Families for USP25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP25 Gene

InterPro:
Blocks:
  • Ubiquitin interacting motif
  • Ubiquitin thiolesterase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for USP25 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-specific-processing protease 25 (UBP25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHP3

UniProtKB/Swiss-Prot:

UBP25_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP25: view

Function for USP25 Gene

Molecular function for USP25 Gene

UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.
UniProtKB/Swiss-Prot Function:
The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;.
UniProtKB/Swiss-Prot Induction:
The muscle-specific isoform (USP25m) is up-regulated during myocyte differentiation. Levels increase up to 100-fold towards completion of differentiation.
GENATLAS Biochemistry:
ubiquitin specific protease 25,expressed in testis,pancreas,kidney,liver,lung,brain,heart,skeletal muscle,encoding two alternatively spliced isoforms,deubiquitin enzyme family

Enzyme Numbers (IUBMB) for USP25 Gene

Phenotypes From GWAS Catalog for USP25 Gene

Gene Ontology (GO) - Molecular Function for USP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity TAS,IMP 18538659
GO:0005515 protein binding IPI 18538659
GO:0008233 peptidase activity TAS 10644437
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP25: view
genes like me logo Genes that share phenotypes with USP25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP25

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP25 Gene

Localization for USP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP25 Gene

Cytoplasm.
[Isoform USP25m]: Cytoplasm. Nucleus. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP25 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for USP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA 22590560
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP25: view

Pathways & Interactions for USP25 Gene

genes like me logo Genes that share pathways with USP25: view

Pathways by source for USP25 Gene

1 KEGG pathway for USP25 Gene
1 Qiagen pathway for USP25 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis

Gene Ontology (GO) - Biological Process for USP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10644437
GO:0006508 proteolysis TAS 10644437
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IDA,TAS --
GO:0070536 protein K63-linked deubiquitination IMP 18538659
genes like me logo Genes that share ontologies with USP25: view

No data available for SIGNOR curated interactions for USP25 Gene

Drugs & Compounds for USP25 Gene

(1) Drugs for USP25 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP25: view

Transcripts for USP25 Gene

mRNA/cDNA for USP25 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP25

Alternative Splicing Database (ASD) splice patterns (SP) for USP25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - -
SP2: - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4:
SP5: -
SP6: -
SP7: -
SP8:
SP9:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: -
SP2: -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for USP25 Gene

GeneLoc Exon Structure for
USP25

Expression for USP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP25 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for USP25 Gene

This gene is overexpressed in Lymph node (13.9), Monocytes (8.8), Plasma (7.6), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP25 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP25

SOURCE GeneReport for Unigene cluster for USP25 Gene:

Hs.743994

mRNA Expression by UniProt/SwissProt for USP25 Gene:

Q9UHP3-UBP25_HUMAN
Tissue specificity: Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific.

Evidence on tissue expression from TISSUES for USP25 Gene

  • Nervous system(4.5)
  • Muscle(2.8)
  • Kidney(2.5)
  • Lung(2.4)
  • Heart(2.3)
  • Spleen(2.3)
  • Liver(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with USP25: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP25 Gene

Orthologs for USP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia USP25 30 31
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia USP25 30 31
  • 94.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia USP25 30 31
  • 93.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Usp25 30
  • 87.79 (n)
Mouse
(Mus musculus)
Mammalia Usp25 30 17 31
  • 86.9 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia USP25 31
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia USP25 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves USP25 30 31
  • 81.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia USP25 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia usp25 30
  • 74.99 (n)
Str.4178 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18074 30
Zebrafish
(Danio rerio)
Actinopterygii usp25 30 31
  • 68.32 (n)
OneToOne
Dr.12045 30
Worm
(Caenorhabditis elegans)
Secernentea K02C4.3 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for USP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for USP25 Gene

ENSEMBL:
Gene Tree for USP25 (if available)
TreeFam:
Gene Tree for USP25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP25: view image

Paralogs for USP25 Gene

(1) SIMAP similar genes for USP25 Gene using alignment to 4 proteins:

  • UBP25_HUMAN
  • H7C1T8_HUMAN
  • H7C253_HUMAN
  • Q96B65_HUMAN
genes like me logo Genes that share paralogs with USP25: view

Variants for USP25 Gene

Additional dbSNP identifiers (rs#s) for USP25 Gene

Structural Variations from Database of Genomic Variants (DGV) for USP25 Gene

Variant ID Type Subtype PubMed ID
dgv4390n100 CNV gain 25217958
esv275197 CNV gain+loss 21479260
esv2762093 CNV gain 21179565
esv3568111 CNV loss 25503493
nsv1132560 CNV duplication 24896259
nsv1133523 CNV deletion 24896259
nsv3461 CNV insertion 18451855
nsv3462 CNV insertion 18451855
nsv459099 CNV gain 19166990
nsv587076 CNV gain 21841781
nsv834050 CNV gain 17160897

Variation tolerance for USP25 Gene

Residual Variation Intolerance Score: 6.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP25 Gene

Disorders for USP25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for USP25 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search USP25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with USP25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP25 Gene

Publications for USP25 Gene

  1. Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase. (PMID: 19909739) Cholay M … Daviet L (Experimental cell research 2010) 3 4 23
  2. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PMID: 18538659) Meulmeester E … Melchior F (Molecular cell 2008) 3 4 23
  3. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. (PMID: 16501887) Bosch-Comas A … Marfany G (Cellular and molecular life sciences : CMLS 2006) 3 4 23
  4. Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. (PMID: 11597335) Valero R … Marfany G (Genome biology 2001) 3 4 23
  5. Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. (PMID: 10612803) Groet J … Nizetic D (Genes, chromosomes & cancer 2000) 2 3 4

Products for USP25 Gene

  • Signalway Proteins for USP25

Sources for USP25 Gene