Aliases for USP25 Gene
External Ids for USP25 Gene
Previous GeneCards Identifiers for USP25 Gene
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
GeneCards Summary for USP25 Gene
USP25 (Ubiquitin Specific Peptidase 25) is a Protein Coding gene. Diseases associated with USP25 include Arthrogryposis, Renal Dysfunction, And Cholestasis 1 and Arthrogryposis, Renal Dysfunction, And Cholestasis 2. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include peptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP28.
UniProtKB/Swiss-Prot Summary for USP25 Gene
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.
The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.