Aliases for USP24 Gene
External Ids for USP24 Gene
Previous GeneCards Identifiers for USP24 Gene
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
GeneCards Summary for USP24 Gene
USP24 (Ubiquitin Specific Peptidase 24) is a Protein Coding gene. Diseases associated with USP24 include Uv-Sensitive Syndrome and Parkinson Disease, Late-Onset. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP34.
UniProtKB/Swiss-Prot Summary for USP24 Gene
Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.