Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008] See more...

Aliases for USP24 Gene

Aliases for USP24 Gene

  • Ubiquitin Specific Peptidase 24 2 3 5
  • Ubiquitin Carboxyl-Terminal Hydrolase 24 3 4
  • Ubiquitin Specific Protease 24 2 3
  • Deubiquitinating Enzyme 24 3 4
  • Ubiquitin Thioesterase 24 3 4
  • Ubiquitin-Specific Processing Protease 24 3
  • Ubiquitin-Specific-Processing Protease 24 4
  • Ubiquitin Thiolesterase 24 3
  • EC 3.4.19.12 4
  • KIAA1057 4

External Ids for USP24 Gene

Previous GeneCards Identifiers for USP24 Gene

  • GC01M055368
  • GC01M054433
  • GC01M054889
  • GC01M054901
  • GC01M055244
  • GC01M055533
  • GC01M053645
  • GC01M055536
  • GC01M055543

Summaries for USP24 Gene

Entrez Gene Summary for USP24 Gene

  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for USP24 Gene

USP24 (Ubiquitin Specific Peptidase 24) is a Protein Coding gene. Diseases associated with USP24 include Parkinson Disease, Late-Onset. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP9X.

UniProtKB/Swiss-Prot Summary for USP24 Gene

  • Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.

Gene Wiki entry for USP24 Gene

Additional gene information for USP24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP24 Gene

Genomics for USP24 Gene

GeneHancer (GH) Regulatory Elements for USP24 Gene

Promoters and enhancers for USP24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J055210 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 764.6 +0.8 794 8.1 ZNF24 ZBTB40 ZBTB6 MLX RBPJ POLR2A CTBP1 CREB1 HCFC1 MIXL1 USP24 LOC100507634 SSBP3-AS1 RPSAP20 MIR4422HG lnc-DHCR24-4
GH01J055190 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.3 +22.5 22468 11.4 SMARCE1 CC2D1A DACH1 ZNF121 TEAD4 ZC3H8 ZNF384 CEBPG CBFA2T2 SMARCA4 USP24 MIR4422HG GYG1P3 lnc-DHCR24-4
GH01J055179 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.3 +34.5 34468 4.2 ZBTB40 SMARCE1 L3MBTL2 TEAD4 CBFA2T2 SMARCA4 ZNF680 TRIM24 ZNF404 ZNF560 SSBP3-AS1 CYB5RL ENSG00000256407 USP24 TTC4 lnc-DHCR24-4
GH01J055140 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.4 +74.8 74840 2.3 ZNF24 CTCF CC2D1A RAD21 ELF3 MAFK NCOA6 ZSCAN21 CREB1 ARID2 SSBP3-AS1 USP24 lnc-DHCR24-4
GH01J055127 Enhancer 1 Ensembl ENCODE dbSUPER 11.5 +86.3 86326 2.7 FOXA1 NR2F6 SP1 HNF1A ZBED1 CEBPA RXRA FOXA2 JUND RUNX3 USP24 lnc-DHCR24-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP24 gene promoter:
  • aMEF-2
  • AML1a
  • AP-1
  • c-Jun
  • GATA-1
  • MEF-2A
  • Olf-1
  • Pax-2
  • Pax-2a
  • TGIF

Genomic Locations for USP24 Gene

Genomic Locations for USP24 Gene
chr1:55,066,359-55,215,368
(GRCh38/hg38)
Size:
149,010 bases
Orientation:
Minus strand
chr1:55,532,032-55,681,039
(GRCh37/hg19)
Size:
149,008 bases
Orientation:
Minus strand

Genomic View for USP24 Gene

Genes around USP24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP24 Gene

Proteins for USP24 Gene

  • Protein details for USP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPU5-UBP24_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 24
    Protein Accession:
    Q9UPU5
    Secondary Accessions:
    • Q6ZSY2
    • Q8N2Y4
    • Q9NXD1

    Protein attributes for USP24 Gene

    Size:
    2620 amino acids
    Molecular mass:
    294365 Da
    Quaternary structure:
    • (Microbial infection) Interacts with human cytomegalovirus protein UL38.
    SequenceCaution:
    • Sequence=AAH29660.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91084.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP24 Gene

Post-translational modifications for USP24 Gene

  • Ubiquitination at Lys275, Lys369, Lys421, Lys620, Lys648, Lys1764, and Lys2097
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for USP24 Gene

Domains & Families for USP24 Gene

Gene Families for USP24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for USP24 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin carboxyl-terminal hydrolase (B7WPF4_HUMAN)
  • Ubiquitin-specific-processing protease 24 (UBP24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UPU5

UniProtKB/Swiss-Prot:

UBP24_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP24: view

Function for USP24 Gene

Molecular function for USP24 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;.
GENATLAS Biochemistry:
uiquitin specific protease 24 (ubiquitin thiolesterase),carboxyterminal hydrolase,deubiquitin enzyme family

Enzyme Numbers (IUBMB) for USP24 Gene

Phenotypes From GWAS Catalog for USP24 Gene

Gene Ontology (GO) - Molecular Function for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP24: view
genes like me logo Genes that share phenotypes with USP24: view

Animal Models for USP24 Gene

MGI Knock Outs for USP24:
  • Usp24 Usp24<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for USP24

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP24 Gene

Localization for USP24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP24 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
extracellular 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with USP24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP24 Gene

Pathways & Interactions for USP24 Gene

genes like me logo Genes that share pathways with USP24: view

Pathways by source for USP24 Gene

SIGNOR curated interactions for USP24 Gene

Activates:

Gene Ontology (GO) - Biological Process for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,TAS --
genes like me logo Genes that share ontologies with USP24: view

Drugs & Compounds for USP24 Gene

No Compound Related Data Available

Transcripts for USP24 Gene

mRNA/cDNA for USP24 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP24 Gene

No ASD Table

Relevant External Links for USP24 Gene

GeneLoc Exon Structure for
USP24
ECgene alternative splicing isoforms for
USP24

Expression for USP24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP24 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for USP24 Gene

This gene is overexpressed in Breast (23.8) and Peripheral blood mononuclear cells (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP24 Gene



Protein tissue co-expression partners for USP24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP24 Gene:

USP24

SOURCE GeneReport for Unigene cluster for USP24 Gene:

Hs.477009

Evidence on tissue expression from TISSUES for USP24 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with USP24: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP24 Gene

Orthologs for USP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP24 33 32
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia USP24 33 32
  • 92.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia USP24 33 32
  • 92.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp24 32
  • 90.12 (n)
mouse
(Mus musculus)
Mammalia Usp24 17 33 32
  • 89.68 (n)
oppossum
(Monodelphis domestica)
Mammalia USP24 33
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP24 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP24 33 32
  • 82.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP24 33
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp24 32
  • 78.35 (n)
Str.4161 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.7973 32
zebrafish
(Danio rerio)
Actinopterygii usp24 33 32
  • 72.95 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F37B12.4 34
  • 29 (a)
T24B8.7 33
  • 15 (a)
OneToMany
Species where no ortholog for USP24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP24 Gene

ENSEMBL:
Gene Tree for USP24 (if available)
TreeFam:
Gene Tree for USP24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP24: view image

Paralogs for USP24 Gene

(1) SIMAP similar genes for USP24 Gene using alignment to 2 proteins:

  • UBP24_HUMAN
  • B7WPF4_HUMAN

Pseudogenes.org Pseudogenes for USP24 Gene

genes like me logo Genes that share paralogs with USP24: view

Variants for USP24 Gene

Sequence variations from dbSNP and Humsavar for USP24 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1557523211 likely-pathogenic, Short stature 55,073,913(-) G/A genic_downstream_transcript_variant, intron_variant
rs1557625169 uncertain-significance, Short stature 55,141,619(-) T/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1557627382 uncertain-significance, Short stature 55,143,068(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000016326 -- 55,206,996(-) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000021167 -- 55,180,421(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USP24 Gene

Variant ID Type Subtype PubMed ID
esv2496177 CNV deletion 19546169
esv3577877 CNV loss 25503493
nsv473865 CNV novel sequence insertion 20440878
nsv481393 CNV novel sequence insertion 20440878
nsv518539 CNV loss 19592680
nsv525879 CNV loss 19592680
nsv817614 CNV gain 22305530
nsv921 CNV insertion 18451855

Variation tolerance for USP24 Gene

Residual Variation Intolerance Score: 1.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP24 Gene

Human Gene Mutation Database (HGMD)
USP24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP24 Gene

Disorders for USP24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search USP24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with USP24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP24 Gene

Publications for USP24 Gene

  1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PMID: 16917932) Li Y … Grupe A (Human mutation 2006) 3 23 43 56
  2. The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. (PMID: 23159851) Zhang L … Gong F (Cell cycle (Georgetown, Tex.) 2012) 3 4 56
  3. Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. (PMID: 20302855) Wu YR … Lee-Chen GJ (Clinica chimica acta; international journal of clinical chemistry 2010) 3 43 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for USP24 Gene

Sources for USP24 Gene