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Aliases for USP24 Gene

Aliases for USP24 Gene

  • Ubiquitin Specific Peptidase 24 2 3 5
  • Ubiquitin-Specific-Processing Protease 24 4
  • Ubiquitin Specific Protease 24 2
  • Deubiquitinating Enzyme 24 4
  • Ubiquitin Thioesterase 24 4
  • EC 3.4.19.12 4
  • KIAA1057 4

External Ids for USP24 Gene

Previous GeneCards Identifiers for USP24 Gene

  • GC01M055368
  • GC01M054433
  • GC01M054889
  • GC01M054901
  • GC01M055244
  • GC01M055533
  • GC01M053645
  • GC01M055536
  • GC01M055543

Summaries for USP24 Gene

Entrez Gene Summary for USP24 Gene

  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for USP24 Gene

USP24 (Ubiquitin Specific Peptidase 24) is a Protein Coding gene. Diseases associated with USP24 include Parkinson Disease, Late-Onset. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP9X.

UniProtKB/Swiss-Prot for USP24 Gene

  • Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Gene Wiki entry for USP24 Gene

Additional gene information for USP24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP24 Gene

Genomics for USP24 Gene

GeneHancer (GH) Regulatory Elements for USP24 Gene

Promoters and enhancers for USP24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I055210 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 564.8 +0.8 794 8.1 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 USP24 LOC100507634 RPSAP20 MIR4422HG GC01P055101
GH01I055204 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +10.3 10261 0.6 HDGF BATF RARA YY1 RUNX3 RXRA CEBPB PPARG NR2F2 ZNF592 USP24 GC01P055101
GH01I055127 Enhancer 0.9 ENCODE dbSUPER 11.5 +87.2 87183 0.9 FOXA2 JUN BATF FOXK2 FOS NR2F6 RUNX3 RXRA ZBED1 NR2F2 USP24 GC01P055101
GH01I055064 Enhancer 0.7 Ensembl ENCODE 13.3 +151.0 151014 0.5 ZNF335 CTCF ZNF449 PRDM10 ZBTB17 GC01P055065 USP24 PCSK9
GH01I055192 Enhancer 0.7 ENCODE 12.4 +23.1 23065 0.2 TEAD4 TAL1 ZIC2 FOSL1 TCF12 NCOR1 CBFA2T2 NFE2 TCF7L2 SMARCE1 USP24 GYG1P3 MIR4422HG GC01P055101
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP24 gene promoter:

Genomic Locations for USP24 Gene

Genomic Locations for USP24 Gene
chr1:55,066,359-55,215,368
(GRCh38/hg38)
Size:
149,010 bases
Orientation:
Minus strand
chr1:55,532,032-55,681,039
(GRCh37/hg19)

Genomic View for USP24 Gene

Genes around USP24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP24 Gene

Proteins for USP24 Gene

  • Protein details for USP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPU5-UBP24_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 24
    Protein Accession:
    Q9UPU5
    Secondary Accessions:
    • Q6ZSY2
    • Q8N2Y4
    • Q9NXD1

    Protein attributes for USP24 Gene

    Size:
    2620 amino acids
    Molecular mass:
    294365 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29660.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91084.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP24 Gene

Post-translational modifications for USP24 Gene

  • Ubiquitination at isoforms=275, posLast=369369, posLast=421421, posLast=620620, isoforms=648, isoforms=1764, and isoforms=2097
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for USP24 Gene

Domains & Families for USP24 Gene

Gene Families for USP24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for USP24 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPU5

UniProtKB/Swiss-Prot:

UBP24_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP24: view

Function for USP24 Gene

Molecular function for USP24 Gene

GENATLAS Biochemistry:
uiquitin specific protease 24 (ubiquitin thiolesterase),carboxyterminal hydrolase,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Enzyme Numbers (IUBMB) for USP24 Gene

Phenotypes From GWAS Catalog for USP24 Gene

Gene Ontology (GO) - Molecular Function for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS,IEA --
genes like me logo Genes that share ontologies with USP24: view
genes like me logo Genes that share phenotypes with USP24: view

Animal Models for USP24 Gene

MGI Knock Outs for USP24:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP24

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP24 Gene

Localization for USP24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP24 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with USP24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP24 Gene

Pathways & Interactions for USP24 Gene

genes like me logo Genes that share pathways with USP24: view

Pathways by source for USP24 Gene

SIGNOR curated interactions for USP24 Gene

Activates:

Gene Ontology (GO) - Biological Process for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,TAS --
genes like me logo Genes that share ontologies with USP24: view

Drugs & Compounds for USP24 Gene

No Compound Related Data Available

Transcripts for USP24 Gene

Unigene Clusters for USP24 Gene

Ubiquitin specific peptidase 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP24 Gene

No ASD Table

Relevant External Links for USP24 Gene

GeneLoc Exon Structure for
USP24
ECgene alternative splicing isoforms for
USP24

Expression for USP24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP24 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for USP24 Gene

This gene is overexpressed in Breast (23.8) and Peripheral blood mononuclear cells (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP24 Gene



Protein tissue co-expression partners for USP24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP24 Gene:

USP24

SOURCE GeneReport for Unigene cluster for USP24 Gene:

Hs.477009

Evidence on tissue expression from TISSUES for USP24 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with USP24: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP24 Gene

Orthologs for USP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP24 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia USP24 33 34
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia USP24 33 34
  • 92.52 (n)
rat
(Rattus norvegicus)
Mammalia Usp24 33
  • 90.12 (n)
mouse
(Mus musculus)
Mammalia Usp24 33 16 34
  • 89.68 (n)
oppossum
(Monodelphis domestica)
Mammalia USP24 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP24 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP24 33 34
  • 82.34 (n)
lizard
(Anolis carolinensis)
Reptilia USP24 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp24 33
  • 78.35 (n)
Str.4161 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7973 33
zebrafish
(Danio rerio)
Actinopterygii usp24 33 34
  • 72.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F37B12.4 35
  • 29 (a)
T24B8.7 34
  • 15 (a)
OneToMany
Species where no ortholog for USP24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP24 Gene

ENSEMBL:
Gene Tree for USP24 (if available)
TreeFam:
Gene Tree for USP24 (if available)

Paralogs for USP24 Gene

Paralogs for USP24 Gene

(1) SIMAP similar genes for USP24 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for USP24 Gene

genes like me logo Genes that share paralogs with USP24: view

Variants for USP24 Gene

Sequence variations from dbSNP and Humsavar for USP24 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000016326 -- 55,206,996(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000021167 -- 55,180,421(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000049358 -- 55,072,294(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000071080 -- 55,143,886(-) AGAGAGA/AGAGA intron_variant
rs1000104225 -- 55,157,662(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USP24 Gene

Variant ID Type Subtype PubMed ID
esv2496177 CNV deletion 19546169
esv3577877 CNV loss 25503493
nsv473865 CNV novel sequence insertion 20440878
nsv481393 CNV novel sequence insertion 20440878
nsv518539 CNV loss 19592680
nsv525879 CNV loss 19592680
nsv817614 CNV gain 22305530
nsv921 CNV insertion 18451855

Variation tolerance for USP24 Gene

Residual Variation Intolerance Score: 1.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP24 Gene

Human Gene Mutation Database (HGMD)
USP24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP24 Gene

Disorders for USP24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search USP24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with USP24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP24 Gene

Publications for USP24 Gene

  1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PMID: 16917932) Li Y … Grupe A (Human mutation 2006) 3 22 44 58
  2. The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. (PMID: 23159851) Zhang L … Gong F (Cell cycle (Georgetown, Tex.) 2012) 3 4 58
  3. Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. (PMID: 20302855) Wu YR … Lee-Chen GJ (Clinica chimica acta; international journal of clinical chemistry 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill LM … Peters EC (Analytical chemistry 2004) 3 4 58

Products for USP24 Gene

Sources for USP24 Gene

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