Aliases for USP22 Gene

Aliases for USP22 Gene

  • Ubiquitin Specific Peptidase 22 2 3 5
  • Ubiquitin Carboxyl-Terminal Hydrolase 22 3 4
  • Ubiquitin Specific Protease 22 2 3
  • Deubiquitinating Enzyme 22 3 4
  • Ubiquitin Thioesterase 22 3 4
  • KIAA1063 2 4
  • USP3L 3 4
  • Ubiquitin-Specific Processing Protease 22 3
  • Ubiquitin-Specific-Processing Protease 22 4
  • Ubiquitin Specific Peptidase 3-Like 2
  • Ubiquitin Thiolesterase 22 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 50
  • USP22 5

External Ids for USP22 Gene

Previous HGNC Symbols for USP22 Gene

  • USP3L

Previous GeneCards Identifiers for USP22 Gene

  • GC17P020956
  • GC17M022551
  • GC17M020808
  • GC17M021064
  • GC17M020843
  • GC17M020106
  • GC17M020902

Summaries for USP22 Gene

GeneCards Summary for USP22 Gene

USP22 (Ubiquitin Specific Peptidase 22) is a Protein Coding gene. Among its related pathways are Chromatin organization and Deubiquitination. Gene Ontology (GO) annotations related to this gene include enzyme binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP51.

UniProtKB/Swiss-Prot Summary for USP22 Gene

  • Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP22 Gene

Genomics for USP22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP22

Top Transcription factor binding sites by QIAGEN in the USP22 gene promoter:
  • AP-2rep
  • AREB6
  • ATF-2
  • CRE-BP1
  • CREB
  • deltaCREB
  • E47
  • LCR-F1
  • Pax-5
  • YY1

Genomic Locations for USP22 Gene

Latest Assembly
chr17:20,999,596-21,043,760
(GRCh38/hg38)
Size:
44,165 bases
Orientation:
Minus strand

Previous Assembly
chr17:20,902,909-20,946,324
(GRCh37/hg19 by Entrez Gene)
Size:
43,416 bases
Orientation:
Minus strand

chr17:20,902,910-20,947,073
(GRCh37/hg19 by Ensembl)
Size:
44,164 bases
Orientation:
Minus strand

Genomic View for USP22 Gene

Genes around USP22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP22 Gene

Proteins for USP22 Gene

  • Protein details for USP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT9-UBP22_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 22
    Protein Accession:
    Q9UPT9
    Secondary Accessions:
    • A0JNS3
    • Q2NLE2
    • Q6MZY4
    • Q8TBS8
    • Q96IW5

    Protein attributes for USP22 Gene

    Size:
    525 amino acids
    Molecular mass:
    59961 Da
    Quaternary structure:
    • Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination (PubMed:18206972, PubMed:27601583). Interacts directly with ATXN7L3; leading to its recruitment to the SAGA complex (PubMed:18206972). Interacts with ATXN7L3 and weakly with ATXN7L3B (PubMed:27601583).
    SequenceCaution:
    • Sequence=AAH25317.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA83015.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP22 Gene

Selected DME Specific Peptides for USP22 Gene

Q9UPT9:
  • HNPKRRKIT
  • SYQESTKQ
  • LFQEFYSG
  • HARHLAGY
  • RKRKAKSC
  • TCFMNCIVQAL
  • GNTCFMN
  • TIGLRGL
  • PHIPYKLLHL
  • CNCIIDQIFTG
  • CDDAIITKA
  • FTRPEHLGSSAKIKC
  • QQDAHEF
  • KRHNLAI
  • CVFFGCF
  • DQWFKCDDA
  • VSTTIDP
  • NLGNTCF
  • WEPTKRELELL

Post-translational modifications for USP22 Gene

  • Ubiquitination at Lys144, Lys166, Lys382, and Lys442
  • Modification sites at PhosphoSitePlus

Other Protein References for USP22 Gene

Domains & Families for USP22 Gene

Gene Families for USP22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP22 Gene

InterPro:
Blocks:
  • Ubiquitin thiolesterase, family 2
  • Zn-finger in ubiquitin thiolesterase

Suggested Antigen Peptide Sequences for USP22 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-specific-processing protease 22 (UBP22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UPT9

UniProtKB/Swiss-Prot:

UBP22_HUMAN :
  • Belongs to the peptidase C19 family. UBP8 subfamily.
Family:
  • Belongs to the peptidase C19 family. UBP8 subfamily.
genes like me logo Genes that share domains with USP22: view

Function for USP22 Gene

Molecular function for USP22 Gene

UniProtKB/Swiss-Prot Function:
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:18206973};.

Enzyme Numbers (IUBMB) for USP22 Gene

Phenotypes From GWAS Catalog for USP22 Gene

Gene Ontology (GO) - Molecular Function for USP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 18206972
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IEA,IMP 18206973
GO:0005515 protein binding IPI 18206972
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP22: view
genes like me logo Genes that share phenotypes with USP22: view

Animal Models for USP22 Gene

MGI Knock Outs for USP22:
  • Usp22 Usp22<tm1a(KOMP)Wtsi>
  • Usp22 Usp22<tm1Dfan>
  • Usp22 Usp22<tm1b(KOMP)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for USP22

miRNA for USP22 Gene

miRTarBase miRNAs that target USP22

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP22

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP22 Gene

Localization for USP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP22 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IDA 18206972
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0070461 colocalizes_with SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with USP22: view

Pathways & Interactions for USP22 Gene

genes like me logo Genes that share pathways with USP22: view

Pathways by source for USP22 Gene

SIGNOR curated interactions for USP22 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for USP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0009792 embryo development ending in birth or egg hatching NAS 16378762
genes like me logo Genes that share ontologies with USP22: view

Drugs & Compounds for USP22 Gene

(1) Drugs for USP22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP22: view

Transcripts for USP22 Gene

mRNA/cDNA for USP22 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP22

Alternative Splicing Database (ASD) splice patterns (SP) for USP22 Gene

No ASD Table

Relevant External Links for USP22 Gene

GeneLoc Exon Structure for
USP22

Expression for USP22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.9), Fetal heart (25.8), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP22 Gene



Protein tissue co-expression partners for USP22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP22

SOURCE GeneReport for Unigene cluster for USP22 Gene:

Hs.462492

mRNA Expression by UniProt/SwissProt for USP22 Gene:

Q9UPT9-UBP22_HUMAN
Tissue specificity: Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.

Evidence on tissue expression from TISSUES for USP22 Gene

  • Nervous system(5)
  • Intestine(4.6)
  • Skin(4.4)
  • Lung(3.6)
  • Eye(2.8)
  • Kidney(2.6)
  • Muscle(2.6)
  • Liver(2.6)
  • Heart(2.4)
  • Lymph node(2.4)
  • Thyroid gland(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with USP22: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP22 Gene

Orthologs for USP22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP22 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia USP22 29 30
  • 97.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia USP22 29 30
  • 89.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Usp22 29
  • 89.46 (n)
Mouse
(Mus musculus)
Mammalia Usp22 29 16 30
  • 89.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia USP22 29 30
  • 88.39 (n)
OneToOne
Chicken
(Gallus gallus)
Aves USP22 29
  • 83.44 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia usp22 29
  • 78.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25481 29
Zebrafish
(Danio rerio)
Actinopterygii usp22 29 30
  • 80.02 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012119 29
  • 60.92 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta not 29 30 31
  • 60.69 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR551W 29
  • 48.21 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 29 30 32
  • 45.68 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06974g 29
  • 43.19 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0647300 29
  • 50 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1941 30
  • 56 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU02375 29
  • 46.67 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp8 29
  • 44.63 (n)
Species where no ortholog for USP22 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for USP22 Gene

ENSEMBL:
Gene Tree for USP22 (if available)
TreeFam:
Gene Tree for USP22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP22: view image
Alliance of Genome Resources:
Additional Orthologs for USP22

Paralogs for USP22 Gene

(6) SIMAP similar genes for USP22 Gene using alignment to 5 proteins:

  • UBP22_HUMAN
  • J3QRV6_HUMAN
  • J3QS30_HUMAN
  • K7ERX6_HUMAN
  • K7ESK0_HUMAN

Pseudogenes.org Pseudogenes for USP22 Gene

genes like me logo Genes that share paralogs with USP22: view

Variants for USP22 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for USP22 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for USP22 Gene

Variant ID Type Subtype PubMed ID
dgv515n67 CNV gain 20364138
esv2103773 CNV deletion 18987734
esv2751619 CNV gain 17911159
esv28319 CNV loss 19812545
esv3554253 CNV deletion 23714750
nsv1059146 CNV gain 25217958
nsv1072726 CNV deletion 25765185
nsv1078306 OTHER inversion 25765185
nsv1118751 CNV deletion 24896259
nsv827917 CNV gain 20364138

Variation tolerance for USP22 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP22
Leiden Open Variation Database (LOVD)
USP22

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP22 Gene

Disorders for USP22 Gene

Additional Disease Information for USP22

No disorders were found for USP22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP22 Gene

Publications for USP22 Gene

  1. Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. (PMID: 27601583) Li W … Dent SYR (Molecular and cellular biology 2016) 3 4
  2. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. (PMID: 18469533) Zhang XY … McMahon SB (Cell cycle (Georgetown, Tex.) 2008) 3 4
  3. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y … Devys D (Molecular cell 2008) 3 4
  4. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. (PMID: 18206973) Zhang XY … McMahon SB (Molecular cell 2008) 3 4
  5. The expression patterns of deubiquitinating enzymes, USP22 and Usp22. (PMID: 16378762) Lee HJ … Baek KH (Gene expression patterns : GEP 2006) 3 4

Products for USP22 Gene

Sources for USP22 Gene