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Aliases for USP17L5 Gene

Aliases for USP17L5 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 5 2 3 5
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 5 4
  • Deubiquitinating Enzyme 17-Like Protein 5 4
  • Ubiquitin Thioesterase 17-Like Protein 5 4
  • Ubiquitin Specific Peptidase 17-Like 5 2
  • EC 4
  • EC 56

External Ids for USP17L5 Gene

Previous GeneCards Identifiers for USP17L5 Gene

  • GC04P008952

Summaries for USP17L5 Gene

GeneCards Summary for USP17L5 Gene

USP17L5 (Ubiquitin Specific Peptidase 17-Like Family Member 5) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L29.

UniProtKB/Swiss-Prot for USP17L5 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Additional gene information for USP17L5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L5 Gene

Genomics for USP17L5 Gene

GeneHancer (GH) Regulatory Elements for USP17L5 Gene

Top Transcription factor binding sites by QIAGEN in the USP17L5 gene promoter:

Genomic Locations for USP17L5 Gene

Genomic Locations for USP17L5 Gene
1,593 bases
Plus strand

Genomic View for USP17L5 Gene

Genes around USP17L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L5 Gene

Proteins for USP17L5 Gene

  • Protein details for USP17L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 5
    Protein Accession:

    Protein attributes for USP17L5 Gene

    530 amino acids
    Molecular mass:
    59683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L5 Gene

Selected DME Specific Peptides for USP17L5 Gene


Post-translational modifications for USP17L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L5 Gene

Gene Families for USP17L5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP17L5 Gene

Suggested Antigen Peptide Sequences for USP17L5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family. USP17 subfamily.
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L5: view

Function for USP17L5 Gene

Molecular function for USP17L5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L5 Gene

Gene Ontology (GO) - Molecular Function for USP17L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L5: view

Phenotypes for USP17L5 Gene

genes like me logo Genes that share phenotypes with USP17L5: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L5 Gene

Localization for USP17L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L5 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP17L5 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP17L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for USP17L5 Gene

Pathways & Interactions for USP17L5 Gene

genes like me logo Genes that share pathways with USP17L5: view

Pathways by source for USP17L5 Gene

Gene Ontology (GO) - Biological Process for USP17L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L5: view

No data available for SIGNOR curated interactions for USP17L5 Gene

Drugs & Compounds for USP17L5 Gene

No Compound Related Data Available

Transcripts for USP17L5 Gene

mRNA/cDNA for USP17L5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L5 Gene

No ASD Table

Relevant External Links for USP17L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP17L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP17L5 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L5 Gene:


SOURCE GeneReport for Unigene cluster for USP17L5 Gene:

genes like me logo Genes that share expression patterns with USP17L5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L5 Gene

Orthologs for USP17L5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
-- 34
  • 94 (a)
(Canis familiaris)
Mammalia -- 34
  • 60 (a)
-- 34
  • 53 (a)
-- 34
  • 53 (a)
-- 34
  • 53 (a)
-- 34
  • 53 (a)
-- 34
  • 52 (a)
-- 34
  • 52 (a)
(Mus musculus)
Mammalia Usp17lb 34
  • 47 (a)
Usp17la 34
  • 45 (a)
Usp17lc 34
  • 45 (a)
Usp17ld 34
  • 44 (a)
Usp17le 34
  • 44 (a)
(Danio rerio)
Actinopterygii usp42 34
  • 17 (a)
fruit fly
(Drosophila melanogaster)
Insecta scny 34
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 34
  • 20 (a)
Species where no ortholog for USP17L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L5 Gene

Gene Tree for USP17L5 (if available)
Gene Tree for USP17L5 (if available)

Paralogs for USP17L5 Gene

genes like me logo Genes that share paralogs with USP17L5: view

Variants for USP17L5 Gene

Sequence variations from dbSNP and Humsavar for USP17L5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs139738122 -- 9,338,874(+) T/G upstream_transcript_variant
rs142784386 -- 9,338,743(+) A/T upstream_transcript_variant
rs147432277 -- 9,338,787(+) C/T upstream_transcript_variant
rs199855117 -- 9,340,493(+) G/A/C coding_sequence_variant, missense_variant
rs200006135 -- 9,340,692(+) G/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for USP17L5 Gene

Variant ID Type Subtype PubMed ID
dgv2934e59 CNV duplication 20981092
dgv922e199 CNV deletion 23128226
esv1010945 CNV gain 20482838
esv22777 CNV gain+loss 19812545
esv2678198 CNV deletion 23128226
esv2727131 CNV deletion 23290073
esv2759222 CNV gain+loss 17122850
esv2763860 CNV gain+loss 21179565
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1077962 CNV duplication 25765185
nsv1078532 CNV duplication 25765185
nsv1078533 CNV duplication 25765185
nsv1115664 CNV duplication 24896259
nsv1124886 CNV duplication 24896259
nsv1128885 CNV duplication 24896259
nsv1132583 CNV duplication 24896259
nsv1139811 CNV duplication 24896259
nsv1139812 CNV duplication 24896259
nsv1149003 CNV duplication 26484159
nsv1154116 CNV duplication 26484159
nsv4227 CNV deletion 18451855
nsv428437 CNV gain 18775914
nsv469637 CNV loss 16826518
nsv471623 CNV gain+loss 15918152
nsv515014 CNV gain 21397061
nsv515015 CNV gain 21397061
nsv515016 CNV gain 21397061
nsv949795 CNV duplication 24416366
nsv949796 CNV duplication 24416366
nsv980182 CNV duplication 23825009

Additional Variant Information for USP17L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L5 Gene

Disorders for USP17L5 Gene

Additional Disease Information for USP17L5

No disorders were found for USP17L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L5 Gene

Publications for USP17L5 Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin JM … Baek KH (BMC genomics 2006) 2 3 4 58
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows JF … Johnston JA (Genomics 2005) 2 3 4 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S … Baek KH (The Journal of biological chemistry 2011) 3 58

Products for USP17L5 Gene

Sources for USP17L5 Gene

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