Aliases for USP17L4 Gene

Aliases for USP17L4 Gene

  • Ubiquitin Specific Peptidase 17 Like Family Member 4 2 3 5
  • Inactive Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 4 3 4
  • Ubiquitin Specific Peptidase 17-Like 4 2
  • EC 50
  • USP17L4 5

External Ids for USP17L4 Gene

Previous GeneCards Identifiers for USP17L4 Gene

  • GC08P007187
  • GC08P007181
  • GC08P007194

Summaries for USP17L4 Gene

GeneCards Summary for USP17L4 Gene

USP17L4 (Ubiquitin Specific Peptidase 17 Like Family Member 4) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP17L8.

Additional gene information for USP17L4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP17L4 Gene

Genomics for USP17L4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP17L4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J007354 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +18.0 17989 1.8 ZNF207 ZNF654 ZNF600 ZNF10 ZIC2 CTCF REST TRIM22 ZNF513 ZNF843 FAM66B MCPH1 FAM86B3P piR-31534-629 USP17L4 ZNF705G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP17L4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP17L4

Top Transcription factor binding sites by QIAGEN in the USP17L4 gene promoter:
  • AML1a
  • C/EBPbeta
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • HTF
  • p53

Genomic Locations for USP17L4 Gene

Latest Assembly
1,593 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,593 bases
Plus strand

(GRCh37/hg19 by Ensembl)
1,593 bases
Plus strand

Genomic View for USP17L4 Gene

Genes around USP17L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L4 Gene

Proteins for USP17L4 Gene

  • Protein details for USP17L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4
    Protein Accession:

    Protein attributes for USP17L4 Gene

    530 amino acids
    Molecular mass:
    59636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L4 Gene

Selected DME Specific Peptides for USP17L4 Gene


Post-translational modifications for USP17L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L4 Gene

Gene Families for USP17L4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP17L4 Gene

Suggested Antigen Peptide Sequences for USP17L4 Gene

GenScript: Design optimal peptide antigens:
  • Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 (U17L4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family. USP17 subfamily.
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L4: view

Function for USP17L4 Gene

Enzyme Numbers (IUBMB) for USP17L4 Gene

Gene Ontology (GO) - Molecular Function for USP17L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA 21873635
genes like me logo Genes that share ontologies with USP17L4: view
genes like me logo Genes that share phenotypes with USP17L4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP17L4

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L4 Gene

Localization for USP17L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L4 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP17L4 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 3
cytosol 3

Gene Ontology (GO) - Cellular Components for USP17L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with USP17L4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for USP17L4 Gene

Pathways & Interactions for USP17L4 Gene

genes like me logo Genes that share pathways with USP17L4: view

Pathways by source for USP17L4 Gene

Interacting Proteins for USP17L4 Gene

Gene Ontology (GO) - Biological Process for USP17L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016579 protein deubiquitination IBA 21873635
GO:0018215 protein phosphopantetheinylation IEA --
GO:0042981 regulation of apoptotic process IBA 21873635
genes like me logo Genes that share ontologies with USP17L4: view

No data available for SIGNOR curated interactions for USP17L4 Gene

Drugs & Compounds for USP17L4 Gene

No Compound Related Data Available

Transcripts for USP17L4 Gene

mRNA/cDNA for USP17L4 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP17L4

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L4 Gene

No ASD Table

Relevant External Links for USP17L4 Gene

GeneLoc Exon Structure for

Expression for USP17L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP17L4 Gene

SOURCE GeneReport for Unigene cluster for USP17L4 Gene:

genes like me logo Genes that share expression patterns with USP17L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L4 Gene

Orthologs for USP17L4 Gene

Evolution for USP17L4 Gene

Gene Tree for USP17L4 (if available)
Gene Tree for USP17L4 (if available)
Alliance of Genome Resources:
Additional Orthologs for USP17L4

No data available for Orthologs for USP17L4 Gene

Paralogs for USP17L4 Gene

genes like me logo Genes that share paralogs with USP17L4: view

Variants for USP17L4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for USP17L4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for USP17L4 Gene

Variant ID Type Subtype PubMed ID
dgv11911n54 CNV loss 21841781
dgv11912n54 CNV loss 21841781
dgv2035e212 CNV gain 25503493
dgv6878n100 CNV gain 25217958
dgv6879n100 CNV gain 25217958
dgv6882n100 CNV gain 25217958
dgv6884n100 CNV gain 25217958
dgv6885n100 CNV gain 25217958
dgv6887n100 CNV loss 25217958
dgv6888n100 CNV gain+loss 25217958
dgv6889n100 CNV loss 25217958
dgv6890n100 CNV gain 25217958
dgv6891n100 CNV gain+loss 25217958
dgv6892n100 CNV loss 25217958
dgv6893n100 CNV gain 25217958
dgv6894n100 CNV gain+loss 25217958
dgv6895n100 CNV loss 25217958
dgv6896n100 CNV gain+loss 25217958
dgv6897n100 CNV gain 25217958
dgv6898n100 CNV loss 25217958
dgv6899n100 CNV gain 25217958
dgv6900n100 CNV gain+loss 25217958
dgv6901n100 CNV gain+loss 25217958
dgv6902n100 CNV gain 25217958
dgv6903n100 CNV loss 25217958
dgv6904n100 CNV gain 25217958
dgv6905n100 CNV gain 25217958
dgv6906n100 CNV gain 25217958
dgv6907n100 CNV loss 25217958
dgv6908n100 CNV gain 25217958
dgv6909n100 CNV gain 25217958
dgv6910n100 CNV gain+loss 25217958
dgv6911n100 CNV loss 25217958
dgv6912n100 CNV loss 25217958
dgv6913n100 CNV gain 25217958
dgv6914n100 CNV gain+loss 25217958
dgv6915n100 CNV gain 25217958
esv1000362 CNV gain 20482838
esv21583 CNV gain+loss 19812545
esv2759589 CNV gain+loss 17122850
esv2761169 CNV gain+loss 21179565
esv2764098 CNV gain+loss 21179565
esv33606 CNV gain+loss 17666407
esv3616114 CNV loss 21293372
esv3891318 CNV gain 25118596
esv3891324 CNV gain 25118596
nsv1023986 CNV loss 25217958
nsv1026778 CNV gain 25217958
nsv1027709 CNV gain+loss 25217958
nsv1028208 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv1075101 CNV deletion 25765185
nsv1161709 CNV duplication 26073780
nsv1161710 CNV deletion 26073780
nsv1161711 OTHER complex 26073780
nsv428194 CNV gain+loss 18775914
nsv471650 CNV gain+loss 15918152
nsv510977 OTHER complex 20534489
nsv515968 CNV gain+loss 19592680
nsv610036 CNV loss 21841781
nsv821142 CNV deletion 20802225
nsv821656 CNV gain 15273396
nsv8281 CNV gain+loss 18304495
nsv831223 CNV loss 17160897
nsv831224 CNV gain+loss 17160897
nsv831225 CNV loss 17160897
nsv951091 CNV deletion 24416366
nsv971277 CNV duplication 23825009

Additional Variant Information for USP17L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for USP17L4 Gene

Disorders for USP17L4 Gene

Additional Disease Information for USP17L4

No disorders were found for USP17L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L4 Gene

Publications for USP17L4 Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin JM … Baek KH (BMC genomics 2006) 2 3 4
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows JF … Johnston JA (Genomics 2005) 2 3 4
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4
  4. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M … Johnston JA (Nature communications 2011) 3
  5. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S … Baek KH (The Journal of biological chemistry 2011) 3

Products for USP17L4 Gene

Sources for USP17L4 Gene