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Aliases for USP17L2 Gene

Aliases for USP17L2 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 2 2 3 5
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 2 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 2 3 4
  • Deubiquitinating Enzyme 17-Like Protein 2 3 4
  • Ubiquitin Thioesterase 17-Like Protein 2 3 4
  • Ubiquitin Specific Peptidase 17-Like 2 2 3
  • Deubiquitinating Protein 3 3 4
  • Deubiquitinating Enzyme 3 2 3
  • DUB-3 3 4
  • USP17 3 4
  • DUB3 3 4
  • Ubiquitin Thiolesterase 17-Like Protein 2 3
  • Ubiquitin Carboxyl-Terminal Hydrolase 17 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56
  • USP17L 4
  • USP17H 4
  • USP17I 4
  • USP17J 4
  • USP17K 4
  • USP17M 4

External Ids for USP17L2 Gene

Previous GeneCards Identifiers for USP17L2 Gene

  • GC08M012034
  • GC08M011994

Summaries for USP17L2 Gene

Entrez Gene Summary for USP17L2 Gene

  • DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]

GeneCards Summary for USP17L2 Gene

USP17L2 (Ubiquitin Specific Peptidase 17-Like Family Member 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP17L1.

UniProtKB/Swiss-Prot for USP17L2 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of Lys-48- and Lys-63-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.

Additional gene information for USP17L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L2 Gene

Genomics for USP17L2 Gene

GeneHancer (GH) Regulatory Elements for USP17L2 Gene

Promoters and enhancers for USP17L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I012138 Promoter 0.5 EPDnew 550.8 +0.2 208 0.1 USP17L2 USP17L7 GC08M011947 FAM66D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP17L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for USP17L2 Gene

Genomic Locations for USP17L2 Gene
chr8:12,137,168-12,139,077
(GRCh38/hg38)
Size:
1,910 bases
Orientation:
Minus strand
chr8:11,994,677-11,996,586
(GRCh37/hg19)

Genomic View for USP17L2 Gene

Genes around USP17L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L2 Gene

Proteins for USP17L2 Gene

  • Protein details for USP17L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6R6M4-U17L2_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17
    Protein Accession:
    Q6R6M4

    Protein attributes for USP17L2 Gene

    Size:
    530 amino acids
    Molecular mass:
    59619 Da
    Quaternary structure:
    • Interacts with SUDS3; the interaction is direct.
    Miscellaneous:
    • Overexpressed in a subset of human breast cancers, overexpression leading to an abnormally high level of CDC25A, which arrests cells through replication stress or premature mitosis, the latter occurring when CDK1 is activated inappropriately.

neXtProt entry for USP17L2 Gene

Selected DME Specific Peptides for USP17L2 Gene

Q6R6M4:
  • AQSVKQAL
  • SDTFDPYLDI
  • WRSQIKCL
  • VYVLYAVLVH
  • QALEQLVKPEELNGENAYHCG
  • HEFLMFTVDAMKKACLPGHKQVDHH
  • QCLTYTPPLANY
  • SVLSQQAYVLFYI
  • TLTLHTSAKVLILVLKRFSDV
  • LVERATQESTLDHWKF
  • CTMQAHIT
  • RVDLCDDLAPVARQLAPR
  • GFHRGKQED

Post-translational modifications for USP17L2 Gene

No Post-translational modifications

Other Protein References for USP17L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L2 Gene

Gene Families for USP17L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP17L2 Gene

Suggested Antigen Peptide Sequences for USP17L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6R6M4

UniProtKB/Swiss-Prot:

U17L2_HUMAN :
  • Belongs to the peptidase C19 family. USP17 subfamily.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L2: view

Function for USP17L2 Gene

Molecular function for USP17L2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of Lys-48- and Lys-63-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4/interleukin-4, IL6/interleukin-6 and chemokines including CXCL8 and CXCL12 (at protein level). Up-regulated during the G1/S transition of the cell cycle.

Enzyme Numbers (IUBMB) for USP17L2 Gene

Gene Ontology (GO) - Molecular Function for USP17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IMP 19188362
GO:0005515 protein binding IPI 21239494
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L2: view
genes like me logo Genes that share phenotypes with USP17L2: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L2 Gene

Localization for USP17L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L2 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP17L2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21239494
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA 19188362
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP17L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for USP17L2 Gene

Pathways & Interactions for USP17L2 Gene

genes like me logo Genes that share pathways with USP17L2: view

Pathways by source for USP17L2 Gene

Gene Ontology (GO) - Biological Process for USP17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007093 mitotic cell cycle checkpoint IMP 20228808
genes like me logo Genes that share ontologies with USP17L2: view

No data available for SIGNOR curated interactions for USP17L2 Gene

Drugs & Compounds for USP17L2 Gene

No Compound Related Data Available

Transcripts for USP17L2 Gene

mRNA/cDNA for USP17L2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L2 Gene

No ASD Table

Relevant External Links for USP17L2 Gene

GeneLoc Exon Structure for
USP17L2
ECgene alternative splicing isoforms for
USP17L2

Expression for USP17L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP17L2 Gene

Protein differential expression in normal tissues from HIPED for USP17L2 Gene

This gene is overexpressed in Breast (50.9) and Fetal gut (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP17L2 Gene



Protein tissue co-expression partners for USP17L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L2 Gene:

USP17L2

SOURCE GeneReport for Unigene cluster for USP17L2 Gene:

Hs.531448

mRNA Expression by UniProt/SwissProt for USP17L2 Gene:

Q6R6M4-U17L2_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with USP17L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L2 Gene

Orthologs for USP17L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 60 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17lb 34
  • 47 (a)
ManyToMany
Usp17la 34
  • 46 (a)
ManyToMany
Usp17lc 34
  • 45 (a)
ManyToMany
Usp17ld 34
  • 45 (a)
ManyToMany
Usp17le 34
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 34
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 34
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 34
  • 20 (a)
OneToMany
Species where no ortholog for USP17L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L2 Gene

ENSEMBL:
Gene Tree for USP17L2 (if available)
TreeFam:
Gene Tree for USP17L2 (if available)

Paralogs for USP17L2 Gene

Variants for USP17L2 Gene

Sequence variations from dbSNP and Humsavar for USP17L2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1008742680 -- 12,140,222(-) C/G upstream_transcript_variant
rs10090565 -- 12,140,019(-) G/A upstream_transcript_variant
rs10090570 -- 12,140,021(-) G/A upstream_transcript_variant
rs1012872703 -- 12,139,518(-) G/A upstream_transcript_variant
rs1022360289 -- 12,138,011(-) A/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for USP17L2 Gene

Variant ID Type Subtype PubMed ID
nsv967564 CNV duplication 23825009
nsv951104 CNV deletion 24416366
nsv8288 CNV gain+loss 18304495
nsv610313 CNV loss 21841781
nsv610309 CNV loss 21841781
nsv610297 CNV gain 21841781
nsv516685 CNV gain+loss 19592680
nsv471462 CNV gain 19718026
nsv442420 CNV gain+loss 18776908
nsv428195 CNV gain 18775914
nsv1161718 OTHER complex 26073780
nsv1139930 CNV duplication 24896259
nsv1110510 CNV duplication 24896259
nsv1077517 CNV duplication 25765185
nsv1034132 CNV gain 25217958
esv3616267 CNV loss 21293372
esv3584578 CNV gain 24956385
esv3447577 CNV duplication 20981092
esv2759593 CNV gain+loss 17122850
esv2736614 CNV deletion 23290073
esv2550155 CNV deletion 19546169
esv22986 CNV gain+loss 19812545
esv1009029 CNV gain 20482838
dgv7026n100 CNV gain+loss 25217958
dgv7025n100 CNV gain 25217958
dgv7021n100 CNV loss 25217958
dgv7020n100 CNV loss 25217958
dgv7019n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7017n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7015n100 CNV gain 25217958
dgv27n31 CNV gain 19718026
dgv244e55 CNV gain 17911159
dgv154e203 CNV gain+loss 21179565
dgv1375e214 CNV gain 21293372
dgv1270e199 CNV deletion 23128226
dgv11964n54 CNV loss 21841781
dgv11961n54 CNV loss 21841781
dgv11960n54 CNV gain 21841781

Variation tolerance for USP17L2 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP17L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP17L2 Gene

Disorders for USP17L2 Gene

Additional Disease Information for USP17L2

No disorders were found for USP17L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L2 Gene

Publications for USP17L2 Gene

  1. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. (PMID: 14699124) Burrows JF … Johnston JA (The Journal of biological chemistry 2004) 3 4 22 58
  2. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M … Johnston JA (Nature communications 2011) 3 4 58
  3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S … Baek KH (The Journal of biological chemistry 2011) 3 4 58
  4. The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. (PMID: 20368735) Chen R … Shu HB (Cell research 2010) 3 4 58
  5. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. (PMID: 20403174) Burrows JF … Johnston JA (BMC genomics 2010) 3 4 58

Products for USP17L2 Gene

Sources for USP17L2 Gene

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