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Aliases for USP17L15 Gene
Aliases for USP17L15 Gene
External Ids for USP17L15 Gene
- HGNC: 44443
- NCBI Entrez Gene: 100288520
- Ensembl: ENSG00000223569
- UniProtKB/Swiss-Prot: C9J2P7
Summaries for USP17L15 Gene
GeneCards Summary for USP17L15 Gene
USP17L15 (Ubiquitin Specific Peptidase 17 Like Family Member 15) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L11.
UniProtKB/Swiss-Prot Summary for USP17L15 Gene
-
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Additional gene information for USP17L15 Gene
- Alliance of Genome Resources
- Search for USP17L15 at DataMed
- Search for USP17L15 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP17L15 Gene
Genomics for USP17L15 Gene
Genomic Locations for USP17L15 Gene
Latest Assembly
- chr4:9,234,385-9,236,046
- (GRCh38/hg38)
- Size:
- 1,662 bases
- Orientation:
- Plus strand
Previous Assembly
- chr4:9,236,111-9,237,772
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 1,662 bases
- Orientation:
- Plus strand
Genomic View for USP17L15 Gene
Genes around USP17L15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by HGNC
- 4p16.1 by Entrez Gene
- 4p16.1 by Ensembl
USP17L15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for USP17L15 Gene
No data available for GeneHancer (GH) Regulatory Elements for USP17L15 Gene
Proteins for USP17L15 Gene
-
Protein details for USP17L15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- C9J2P7-U17LF_HUMAN
- Recommended name:
- Ubiquitin carboxyl-terminal hydrolase 17-like protein 15
- Protein Accession:
- C9J2P7
Protein attributes for USP17L15 Gene
- Size:
- 553 amino acids
- Molecular mass:
- 62502 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for USP17L15 Gene
No Post-translational modifications
Other Protein References for USP17L15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for USP17L15
- Origene Custom Protein Services for USP17L15
Assay products for research
No data available for DME Specific Peptides for USP17L15 Gene
Domains & Families for USP17L15 Gene
Gene Families for USP17L15 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for USP17L15 Gene
Graphical View of Domain Structure for InterPro Entry
C9J2P7- Family:
-
- Belongs to the peptidase C19 family. USP17 subfamily.
No data available for Suggested Antigen Peptide Sequences for USP17L15 Gene
Function for USP17L15 Gene
Molecular function for USP17L15 Gene
- UniProtKB/Swiss-Prot Function:
- Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;.
Enzyme Numbers (IUBMB) for USP17L15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IBA | 21873635 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008234 | cysteine-type peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Browse CRISPR knockouts for USP17L15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP17L15
miRNA products for research
Inhibitory RNAs for research
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP17L15
Clone products for research
- Sino Biological Human cDNA Clone for USP17L15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP17L15
Cell Lines for research
-
Horizon Cell Lines for USP17L15
No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L15 Gene
Localization for USP17L15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for USP17L15 Gene
- Nucleus. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 4 |
| endoplasmic reticulum | 3 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005829 | cytosol | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for USP17L15 Gene
Pathways & Interactions for USP17L15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Deubiquitination |
.74
|
|
| 2 | Metabolism of proteins | ||
Pathways by source for USP17L15 Gene
4 Reactome pathways for USP17L15 Gene
Interacting Proteins for USP17L15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0016579 | protein deubiquitination | IBA | 21873635 |
| GO:0018215 | protein phosphopantetheinylation | IEA | -- |
| GO:0042981 | regulation of apoptotic process | IBA | 21873635 |
No data available for SIGNOR curated interactions for USP17L15 Gene
Transcripts for USP17L15 Gene
mRNA/cDNA for USP17L15 Gene
- 1 REFSEQ mRNAs :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000456464 1662 nts (view in UCSC)
CRISPR products for research
- Browse CRISPR knockouts for USP17L15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP17L15
miRNA products for research
Inhibitory RNAs for research
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP17L15
Clone products for research
- Sino Biological Human cDNA Clone for USP17L15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP17L15
Relevant External Links for USP17L15 Gene
- GeneLoc Exon Structure for
- USP17L15
Expression for USP17L15 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP17L15
SOURCE GeneReport for Unigene cluster for USP17L15 Gene:
Hs.528621Primer products for research
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L15 Gene
Orthologs for USP17L15 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Usp17lb 30 |
|
ManyToMany | |
| Usp17lc 30 |
|
ManyToMany | |||
| Usp17la 30 |
|
ManyToMany | |||
| Usp17ld 30 |
|
ManyToMany | |||
| Usp17le 30 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | usp42 30 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | scny 30 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP8 30 |
|
OneToMany |
- Species where no ortholog for USP17L15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for USP17L15 Gene
- ENSEMBL:
- Gene Tree for USP17L15 (if available)
- TreeFam:
- Gene Tree for USP17L15 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for USP17L15
Paralogs for USP17L15 Gene
Paralogs for USP17L15 Gene
- USP17L11 5
- USP17L12 5
- USP17L17 5
- USP17L18 5
- USP17L19 5
- USP17L20 5
- USP17L21 5
- USP17L22 5
- USP17L24 5
- USP17L25 5
- USP17L26 5
- USP17L5 5
- USP17L27 5
- USP17L28 5
- USP17L29 5
- USP17L30 5
- USP17L13 5
- USP17L10 5
- USP17L2 5
- USP17L1 5
- USP17L8 5
- USP17L3 5
- USP17L4 5
- USP17L7 5
- USP42 5
- USP36 5
- USP17L23 5
- USP31 5
- USP47 5
- USP6 5
- USP32 5
- USP43 5
- USP19 5
- USP10 5
- USP27X 5
- USP49 5
- USP4 5
- USP38 5
- USP33 5
- USP35 5
- USP44 5
- USP25 5
- USP16 5
- USP11 5
- USP7 5
- USP22 5
- USP45 5
- USP15 5
- USP28 5
- USP21 5
- USP9X 5
- USP51 5
- USP8 5
- USP20 5
- USP2 5
- USP9Y 5
- USP14 5
- USP48 5
- USP3 5
- USP24 5
- USP1 5
- USP34 5
- USP30 5
- USP40 5
- USP50 5
- USP5 5
- USP29 5
- USP13 5
- USP37 5
- USP26 5
- USP18 5
- USP41 5
- USP17L18 29
- USP17L20 29
- USP17L21 29
- USP17L5 29
- USP17L25 29
- USP17L11 29
- USP17L12 29
- USP17L22 29
- USP17L29 29
- USP17L28 29
- USP17L10 29
- USP17L17 29
- USP17L26 29
- USP17L27 29
- USP17L24 29
- USP17L30 29
- USP17L13 29
- USP17L19 29
(31) SIMAP similar genes for USP17L15 Gene using alignment to 1 proteins:
- U17LF_HUMAN
Variants for USP17L15 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv922e199 | CNV | deletion | 23128226 |
| esv2678198 | CNV | deletion | 23128226 |
| esv2759222 | CNV | gain+loss | 17122850 |
| esv2763860 | CNV | gain+loss | 21179565 |
| esv34196 | OTHER | inversion | 12058347 |
| nsv1005698 | CNV | gain | 25217958 |
| nsv1077433 | CNV | duplication | 25765185 |
| nsv1118713 | CNV | duplication | 24896259 |
| nsv1141450 | CNV | duplication | 24896259 |
| nsv1147485 | CNV | duplication | 26484159 |
| nsv428437 | CNV | gain | 18775914 |
| nsv949790 | CNV | duplication | 24416366 |
Gene Damage Index Score:
0.53;
11.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for USP17L15 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP17L15 Gene
Disorders for USP17L15 Gene
Additional Disease Information for USP17L15
No disorders were found for USP17L15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L15 Gene
Publications for USP17L15 Gene
- The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M … Johnston JA (Nature communications 2011) 3
- Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S … Baek KH (The Journal of biological chemistry 2011) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. (PMID: 20368735) Chen R … Shu HB (Cell research 2010) 3
- Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y … Dixit VM (Nature cell biology 2010) 3
ExternalLinks
Products for USP17L15 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for USP17L15
- Origene Custom Protein Services for USP17L15
- Browse OriGene Inhibitory RNA Products For USP17L15
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for USP17L15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For USP17L15
- Sino Biological Human cDNA Clone for USP17L15
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for USP17L15 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for USP17L15 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for USP17L15 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for USP17L15 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for USP17L15
- Horizon Cell Lines for USP17L15
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP17L15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP17L15
- Search GeneCopoeia for miRNA 3'UTR Target clone products for USP17L15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP17L15
Sources for USP17L15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources