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This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
USP16 (Ubiquitin Specific Peptidase 16) is a Protein Coding gene. Diseases associated with USP16 include Chronic Myelomonocytic Leukemia and Down Syndrome. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and cysteine-type endopeptidase activity. An important paralog of this gene is USP45.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003713 | transcription coactivator activity | IEA,IDA | 17914355 |
GO:0004197 | cysteine-type endopeptidase activity | IMP | 17914355 |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | TAS,IDA | 17914355 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 17914355 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | TAS | 10077596 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Deubiquitination |
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2 | Metabolism of proteins | ||
3 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
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4 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IEA,IDA | 17914355 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,ISS | -- |
GO:0006508 | proteolysis | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Water | Approved | Pharma | 0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 20b | ^ | 21 |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | USP16 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | USP16 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | USP16 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Usp16 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Usp16 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | USP16 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | USP16 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp16 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68701 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | usp16 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4165 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cyk-3 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP16 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3893402 | CNV | gain | 25118596 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chronic myelomonocytic leukemia |
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down syndrome |
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