This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling ... See more...

Aliases for USP15 Gene

Aliases for USP15 Gene

  • Ubiquitin Specific Peptidase 15 2 3 5
  • Ubiquitin-Specific-Processing Protease 15 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 15 3 4
  • Deubiquitinating Enzyme 15 3 4
  • Ubiquitin Thioesterase 15 3 4
  • KIAA0529 2 4
  • UNPH4 2 3
  • Ubiquitin Specific Protease 15 2
  • Ubiquitin Thiolesterase 15 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 50
  • UNPH-2 3
  • Unph-2 4
  • USP15 5
  • Unph4 4

External Ids for USP15 Gene

Previous GeneCards Identifiers for USP15 Gene

  • GC12P062434
  • GC12P062706
  • GC12P060940
  • GC12P059705

Summaries for USP15 Gene

Entrez Gene Summary for USP15 Gene

  • This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

GeneCards Summary for USP15 Gene

USP15 (Ubiquitin Specific Peptidase 15) is a Protein Coding gene. Diseases associated with USP15 include Breast Cancer. Among its related pathways are Signaling by GPCR and Deubiquitination. Gene Ontology (GO) annotations related to this gene include identical protein binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot Summary for USP15 Gene

  • Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102).
  • (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Gene Wiki entry for USP15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP15 Gene

Genomics for USP15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP15

Top Transcription factor binding sites by QIAGEN in the USP15 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AP-4
  • Brachyury
  • HSF1 (long)
  • HSF1short
  • Nkx3-1
  • Pax-4a

Genomic Locations for USP15 Gene

Latest Assembly
chr12:62,260,338-62,417,431
(GRCh38/hg38)
Size:
157,094 bases
Orientation:
Plus strand

Previous Assembly
chr12:62,654,185-62,810,169
(GRCh37/hg19 by Entrez Gene)
Size:
155,985 bases
Orientation:
Plus strand

chr12:62,654,119-62,811,211
(GRCh37/hg19 by Ensembl)
Size:
157,093 bases
Orientation:
Plus strand

Genomic View for USP15 Gene

Genes around USP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP15 Gene

Proteins for USP15 Gene

  • Protein details for USP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E8-UBP15_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 15
    Protein Accession:
    Q9Y4E8
    Secondary Accessions:
    • Q08AL5
    • Q9H8G9
    • Q9HCA6
    • Q9UNP0
    • Q9Y5B5

    Protein attributes for USP15 Gene

    Size:
    981 amino acids
    Molecular mass:
    112419 Da
    Quaternary structure:
    • A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN) (PubMed:16005295). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct (PubMed:21947082). Forms a complex with SMURF2 and SMAD7 (PubMed:22344298). Interacts with TGFBR1 (PubMed:22344298). Interacts with SART3; the interaction is direct (PubMed:24526689). May interact with RNF20 and RNF40 (PubMed:24526689). May interact with PRKN (PubMed:24852371). Interacts with INCA1 (PubMed:21750715).
    • (Microbial infection) Interacts with human papillomavirus type 16 protein E6.

    Three dimensional structures from OCA and Proteopedia for USP15 Gene

    Alternative splice isoforms for USP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP15 Gene

Selected DME Specific Peptides for USP15 Gene

Q9Y4E8:
  • DSRWFKQWKKYVGFDSWD
  • AAYVLFY
  • RLWNKYMSNT
  • HQQATKK
  • LKEHLIDELDY
  • CIELFTT
  • FLLDGLH
  • KWYYFDD
  • QPGLCGL
  • FHGLFKSTLVCPECAK
  • NEDGTWPR
  • GNTCFMN
  • RFAPQFSG
  • FVKHCKVEVYL
  • DGLHEDLN
  • DPWYCPNCK
  • NLGNTCF
  • YAELIKQMWSG

Post-translational modifications for USP15 Gene

  • Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
  • Ubiquitinated, leading to degradation by the proteasome.
  • Ubiquitination at Lys154, Lys228, Lys353, and Lys605
  • Modification sites at PhosphoSitePlus

Domains & Families for USP15 Gene

Gene Families for USP15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP15 Gene

InterPro:
Blocks:
  • Ubiquitin thiolesterase, family 2
  • Ubiquitin-specific protease DUSP
  • Ubiquitin carboxyl-terminal hydrolase, N-terminal region 2

Suggested Antigen Peptide Sequences for USP15 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin carboxyl-terminal hydrolase (E9PCQ3_HUMAN)
  • Ubiquitin carboxyl-terminal hydrolase (Q08AL5_HUMAN)
  • USP15 protein (Q2NL66_HUMAN)
  • cDNA FLJ77181, highly similar to Homo sapiens ubiquitin specific peptidase 15, mRNA (Q9H8G9_HUMAN)
  • Unph4 (UBP15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4E8

UniProtKB/Swiss-Prot:

UBP15_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP15: view

Function for USP15 Gene

Molecular function for USP15 Gene

UniProtKB/Swiss-Prot Function:
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:10444327, ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:27368102};.
GENATLAS Biochemistry:
ubiquitin specific protease 15,deubiquitin enzyme family

Enzyme Numbers (IUBMB) for USP15 Gene

Phenotypes From GWAS Catalog for USP15 Gene

Gene Ontology (GO) - Molecular Function for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004197 cysteine-type endopeptidase activity TAS,IMP 21947082
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IDA 16005295
GO:0005160 transforming growth factor beta receptor binding IPI 22344298
GO:0005515 protein binding IPI 21209336
genes like me logo Genes that share ontologies with USP15: view
genes like me logo Genes that share phenotypes with USP15: view

Animal Models for USP15 Gene

MGI Knock Outs for USP15:
  • Usp15 Usp15<tm1b(EUCOMM)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for USP15

miRNA for USP15 Gene

miRTarBase miRNAs that target USP15

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP15

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP15 Gene

Localization for USP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP15 Gene

Cytoplasm. Nucleus. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP15 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 2
extracellular 2
lysosome 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21947082
GO:0005737 cytoplasm IEA,IDA 21947082
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with USP15: view

Pathways & Interactions for USP15 Gene

genes like me logo Genes that share pathways with USP15: view

Pathways by source for USP15 Gene

1 Qiagen pathway for USP15 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis
2 Cell Signaling Technology pathways for USP15 Gene

Gene Ontology (GO) - Biological Process for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 22344298
GO:0016032 viral process IEA --
GO:0016579 protein deubiquitination IEA,TAS --
genes like me logo Genes that share ontologies with USP15: view

No data available for SIGNOR curated interactions for USP15 Gene

Drugs & Compounds for USP15 Gene

(1) Drugs for USP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP15: view

Transcripts for USP15 Gene

mRNA/cDNA for USP15 Gene

11 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP15

Alternative Splicing Database (ASD) splice patterns (SP) for USP15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for USP15 Gene

GeneLoc Exon Structure for
USP15

Expression for USP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP15 Gene

This gene is overexpressed in Whole Blood (x9.2).

Protein differential expression in normal tissues from HIPED for USP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP15 Gene



Protein tissue co-expression partners for USP15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP15

SOURCE GeneReport for Unigene cluster for USP15 Gene:

Hs.434951

mRNA Expression by UniProt/SwissProt for USP15 Gene:

Q9Y4E8-UBP15_HUMAN
Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Evidence on tissue expression from TISSUES for USP15 Gene

  • Nervous system(4.6)
  • Skin(4.5)
  • Lung(4.4)
  • Liver(4.4)
  • Intestine(2.5)
  • Bone marrow(2.4)
  • Blood(2.4)
  • Lymph node(2.3)
  • Spleen(2.3)
  • Kidney(2.2)
  • Muscle(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with USP15: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for USP15 Gene

Orthologs for USP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia USP15 29 30
  • 99.68 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia USP15 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia USP15 29 30
  • 96.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia USP15 29 30
  • 95.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Usp15 29
  • 91.6 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia USP15 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Usp15 29 16 30
  • 90.23 (n)
OneToOne
Chicken
(Gallus gallus)
Aves USP15 29 30
  • 87.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia USP15 30
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia usp15 29
  • 81.47 (n)
Zebrafish
(Danio rerio)
Actinopterygii USP15 30
  • 51 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG30421 31
  • 36 (a)
Worm
(Caenorhabditis elegans)
Secernentea F07A11.4 31
  • 31 (a)
H34C03.2 30 31
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 30 32
  • 22 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons UBP11 29
  • 52.69 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0160000 29
  • 51.88 (n)
Os.14909 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2770 30
  • 42 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5425 29
Species where no ortholog for USP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for USP15 Gene

ENSEMBL:
Gene Tree for USP15 (if available)
TreeFam:
Gene Tree for USP15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP15: view image
Alliance of Genome Resources:
Additional Orthologs for USP15

Paralogs for USP15 Gene

(35) SIMAP similar genes for USP15 Gene using alignment to 10 proteins:

  • UBP15_HUMAN
  • E9PCQ3_HUMAN
  • F8VVY7_HUMAN
  • F8VZG8_HUMAN
  • F8W0H4_HUMAN
  • H0YH96_HUMAN
  • H0YHM4_HUMAN
  • H0YI26_HUMAN
  • H0YI31_HUMAN
  • Q2NL66_HUMAN

Pseudogenes.org Pseudogenes for USP15 Gene

genes like me logo Genes that share paralogs with USP15: view

Variants for USP15 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for USP15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for USP15 Gene

Variant ID Type Subtype PubMed ID
esv3394996 CNV insertion 20981092
esv3629732 CNV loss 21293372
nsv469417 CNV gain 19166990
nsv559155 CNV gain 21841781
nsv738 CNV insertion 18451855
nsv821671 CNV loss 15273396
nsv952195 CNV duplication 24416366

Variation tolerance for USP15 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP15 Gene

Human Gene Mutation Database (HGMD)
USP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP15
Leiden Open Variation Database (LOVD)
USP15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP15 Gene

Disorders for USP15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP15 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search USP15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with USP15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP15 Gene

Publications for USP15 Gene

  1. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PMID: 19576224) Huang X … Dubiel W (Journal of molecular biology 2009) 3 4 22
  2. The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. (PMID: 19553310) Vos RM … Howley PM (Journal of virology 2009) 3 4 22
  3. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PMID: 10444327) Baker RT … Sutherland GR (Genomics 1999) 3 4 22
  4. An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. (PMID: 27368102) Jongsma ML … Neefjes J (Cell 2016) 3 4
  5. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. (PMID: 24526689) Long L … Yao T (The Journal of biological chemistry 2014) 3 4

Products for USP15 Gene

Sources for USP15 Gene