Aliases for USP13 Gene

Aliases for USP13 Gene

  • Ubiquitin Specific Peptidase 13 2 3 5
  • Ubiquitin Specific Protease 13 (Isopeptidase T-3) 2 3
  • Ubiquitin-Specific-Processing Protease 13 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 13 3 4
  • Deubiquitinating Enzyme 13 3 4
  • Ubiquitin Thioesterase 13 3 4
  • Isopeptidase T-3 2 4
  • IsoT-3 2 3
  • ISOT3 3 4
  • Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) 3
  • Ubiquitin Thiolesterase 13 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 50
  • ISOT-3 4
  • USP13 5

External Ids for USP13 Gene

Previous GeneCards Identifiers for USP13 Gene

  • GC03P176137
  • GC03P180213
  • GC03P180772
  • GC03P180691
  • GC03P180853
  • GC03P179370
  • GC03P176774

Summaries for USP13 Gene

GeneCards Summary for USP13 Gene

USP13 (Ubiquitin Specific Peptidase 13) is a Protein Coding gene. Diseases associated with USP13 include Fetal Adenoma and Hemangioma Of Subcutaneous Tissue. Among its related pathways are Deubiquitination and Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP5.

UniProtKB/Swiss-Prot Summary for USP13 Gene

  • Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.

Gene Wiki entry for USP13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP13 Gene

Genomics for USP13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for USP13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J179652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 256.5 +0.7 675 3.4 ZNF600 POLR2A CHD4 YY1 MXD4 KLF11 BHLHE40 FEZF1 ZNF341 HOMEZ USP13 HSALNG0030986 GNB4 RF00017-3764 ENSG00000288698 PEX5L
GH03J179651 Promoter 0.3 Ensembl 256.5 -1.1 -1131 0.2 USP13 H3P13 HSALNG0030986 lnc-MRPL47-4 ENSG00000288698
GH03J179603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 -48.4 -48431 3.2 BCLAF1 SP1 ZNF600 MYC SIX5 POLR2A YY1 MXD4 CTCF SMAD5 NDUFB5 MRPL47 ENSG00000288698 TTC14 USP13 MFN1 HSALNG0030980 lnc-ACTL6A-2 ACTL6A
GH03J179738 Enhancer 1 Ensembl ENCODE 17.1 +86.7 86720 1.7 CEBPA YY1 FOXA1 HOMEZ KMT2B FOXA2 KDM6A SMAD4 RXRA ZNF511 USP13 ENSG00000272910 ZNF639 HSALNG0030987 piR-55657-187 ENSG00000288698 PEX5L
GH03J179712 Enhancer 0.7 Ensembl ENCODE 15.5 +62.8 62787 5.8 EBF1 MAFK JUND BACH1 TOE1 POLR2A NFE2L2 EP300 RUNX3 FOS USP13 piR-42491-158 piR-55657-187 ENSG00000288698 PEX5L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP13

Top Transcription factor binding sites by QIAGEN in the USP13 gene promoter:
  • Bach1
  • Brachyury
  • Cdc5
  • Evi-1
  • LCR-F1
  • Nkx2-5
  • Pax-3
  • POU6F1 (c2)
  • SEF-1 (1)
  • Zic1

Genomic Locations for USP13 Gene

Latest Assembly
chr3:179,653,032-179,804,366
(GRCh38/hg38)
Size:
151,335 bases
Orientation:
Plus strand

Previous Assembly
chr3:179,370,828-179,507,189
(GRCh37/hg19 by Entrez Gene)
Size:
136,362 bases
Orientation:
Plus strand

chr3:179,370,543-179,507,189
(GRCh37/hg19 by Ensembl)
Size:
136,647 bases
Orientation:
Plus strand

Genomic View for USP13 Gene

Genes around USP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP13 Gene

Proteins for USP13 Gene

  • Protein details for USP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92995-UBP13_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 13
    Protein Accession:
    Q92995
    Secondary Accessions:
    • A8K2S3
    • B4DYF3
    • D3DNS2
    • Q96B25

    Protein attributes for USP13 Gene

    Size:
    863 amino acids
    Molecular mass:
    97327 Da
    Quaternary structure:
    • Interacts with UFD1. Interacts (via UBA domains) with SIAH2 (when ubiquitinated). Interacts with BAG6; the interaction is direct and may mediate UBL4A deubiquitination (PubMed:24424410). Interacts (via UBA 2 domain) with AMFR; the interaction is direct (PubMed:24424410). Interacts with UBL4A; may be indirect via BAG6 (PubMed:24424410).

    Three dimensional structures from OCA and Proteopedia for USP13 Gene

    Alternative splice isoforms for USP13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP13 Gene

Selected DME Specific Peptides for USP13 Gene

Q92995:
  • NRQQDAQEFFLHL
  • KEGRWVI
  • NLGNSCY
  • ENLWLNLTDG
  • QIKKFTFGLDWVPKK
  • ACRKAVY
  • LFAFISHMGTSTM
  • VKLGTIT
  • VFRFLVEE

Post-translational modifications for USP13 Gene

  • Ubiquitination at Lys18, Lys176, Lys190, Lys259, Lys326, Lys328, Lys389, Lys405, Lys538, Lys565, Lys598, and Lys640
  • Modification sites at PhosphoSitePlus

Domains & Families for USP13 Gene

Gene Families for USP13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP13 Gene

InterPro:
Blocks:
  • Ubiquitin-associated domain
  • Ubiquitin thiolesterase, family 2
  • Zn-finger in ubiquitin thiolesterase

Suggested Antigen Peptide Sequences for USP13 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin carboxyl-terminal hydrolase (B4DYF3_HUMAN)
  • Ubiquitin-specific-processing protease 13 (UBP13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92995

UniProtKB/Swiss-Prot:

UBP13_HUMAN :
  • The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin. Swapping with the UBP-type zinc finger from USP5 restores ability to bind unanchored ubiquitin and subsequent activation of the protein (PubMed:22216260).
  • Belongs to the peptidase C19 family.
Domain:
  • The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin. Swapping with the UBP-type zinc finger from USP5 restores ability to bind unanchored ubiquitin and subsequent activation of the protein (PubMed:22216260).
  • The UBA domains mediate binding to ubiquitin.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP13: view

Function for USP13 Gene

Molecular function for USP13 Gene

UniProtKB/Swiss-Prot Function:
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP13 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes. The weak deubiquitinase activity in vitro suggests the existence of some mechanism that activates the enzyme.
GENATLAS Biochemistry:
ubiquitin specific protease 13,expressed in testis and ovary,ubiquitin C terminal hydrolase family member,deubiquitin enzyme family

Enzyme Numbers (IUBMB) for USP13 Gene

Phenotypes From GWAS Catalog for USP13 Gene

Gene Ontology (GO) - Molecular Function for USP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS,IMP 21811243
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IDA 21811243
GO:0005515 protein binding IEA,IPI 21811243
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP13: view
genes like me logo Genes that share phenotypes with USP13: view

Animal Models for USP13 Gene

MGI Knock Outs for USP13:
  • Usp13 Usp13<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for USP13

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP13

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP13 Gene

Localization for USP13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP13 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
lysosome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP13 Gene

Pathways & Interactions for USP13 Gene

PathCards logo

SuperPathways for USP13 Gene

genes like me logo Genes that share pathways with USP13: view

Pathways by source for USP13 Gene

1 Qiagen pathway for USP13 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis

SIGNOR curated interactions for USP13 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for USP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IMP 21811243
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006914 autophagy IEA --
GO:0008283 cell proliferation IMP 21811243
genes like me logo Genes that share ontologies with USP13: view

Drugs & Compounds for USP13 Gene

(2) Drugs for USP13 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Spautin-1 Pharma Novel autophagy inhibitor 0

(1) ApexBio Compounds for USP13 Gene

Compound Action Cas Number
Spautin-1 Novel autophagy inhibitor 1262888-28-7
genes like me logo Genes that share compounds with USP13: view

Drug products for research

Transcripts for USP13 Gene

mRNA/cDNA for USP13 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
73 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP13

Alternative Splicing Database (ASD) splice patterns (SP) for USP13 Gene

No ASD Table

Relevant External Links for USP13 Gene

GeneLoc Exon Structure for
USP13

Expression for USP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP13 Gene

This gene is overexpressed in Muscle - Skeletal (x21.0) and Heart - Left Ventricle (x5.7).

Protein differential expression in normal tissues from HIPED for USP13 Gene

This gene is overexpressed in Cerebrospinal fluid (51.2) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP13 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP13

SOURCE GeneReport for Unigene cluster for USP13 Gene:

Hs.175322

mRNA Expression by UniProt/SwissProt for USP13 Gene:

Q92995-UBP13_HUMAN
Tissue specificity: Highly expressed in ovary and testes.

Evidence on tissue expression from TISSUES for USP13 Gene

  • Liver(2.7)
  • Muscle(2.6)
  • Blood(2.4)
  • Heart(2.3)
  • Kidney(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with USP13: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP13 Gene

Orthologs for USP13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia USP13 29 30
  • 99.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia USP13 29 30
  • 93.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia USP13 29 30
  • 93.08 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 91 (a)
OneToMany
-- 30
  • 89 (a)
OneToMany
-- 30
  • 85 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Usp13 29 16 30
  • 88.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Usp13 29
  • 88.42 (n)
Oppossum
(Monodelphis domestica)
Mammalia USP13 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves USP13 29 30
  • 78.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia USP13 30
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia usp13 29
  • 73.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16188 29
Zebrafish
(Danio rerio)
Actinopterygii usp13 29 30
  • 72.36 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG12082 30 31
  • 45 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea usp-5 30
  • 34 (a)
OneToMany
T27A3.2 31
  • 31 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP14 30
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9810 30
  • 46 (a)
OneToMany
Species where no ortholog for USP13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for USP13 Gene

ENSEMBL:
Gene Tree for USP13 (if available)
TreeFam:
Gene Tree for USP13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP13: view image
Alliance of Genome Resources:
Additional Orthologs for USP13

Paralogs for USP13 Gene

(1) SIMAP similar genes for USP13 Gene using alignment to 3 proteins:

  • UBP13_HUMAN
  • H7C502_HUMAN
  • H7C5J3_HUMAN

Pseudogenes.org Pseudogenes for USP13 Gene

genes like me logo Genes that share paralogs with USP13: view

Variants for USP13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP13 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs11917211 Benign: not provided 179,708,794(+) C/T
NM_003940.3(USP13):c.642C>T (p.Cys214=)
SYNONYMOUS
rs35132005 Benign: not provided 179,742,292(+) G/A
NM_003940.3(USP13):c.1476G>A (p.Thr492=)
SYNONYMOUS
rs41265421 Benign: not provided 179,754,859(+) C/T
NM_003940.3(USP13):c.1921+5C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for USP13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for USP13 Gene

Variant ID Type Subtype PubMed ID
esv2656680 CNV deletion 23128226
esv2726257 CNV deletion 23290073
esv3562975 CNV deletion 23714750
esv3598847 CNV loss 21293372
esv3893829 CNV loss 25118596
nsv1073696 CNV deletion 25765185
nsv1074642 CNV deletion 25765185
nsv4140 CNV deletion 18451855
nsv522327 CNV loss 19592680

Variation tolerance for USP13 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP13
Leiden Open Variation Database (LOVD)
USP13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP13 Gene

Disorders for USP13 Gene

MalaCards: The human disease database

(3) MalaCards diseases for USP13 Gene - From: COP

Disorder Aliases PubMed IDs
fetal adenoma
  • microfollicular adenoma
hemangioma of subcutaneous tissue
  • angioma of the subcutaneous tissue
pneumothorax, primary spontaneous
  • psp
- elite association - COSMIC cancer census association via MalaCards
Search USP13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with USP13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP13 Gene

Publications for USP13 Gene

  1. The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP). (PMID: 9841226) Timms KM … Gibbs RA (Gene 1998) 3 4 22
  2. USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. (PMID: 24424410) Liu Y … Ye Y (eLife 2014) 3 4
  3. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PMID: 21962518) Liu J … Yuan J (Cell 2011) 3 4
  4. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. (PMID: 21571647) Chen M … Ronai ZA (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
  5. Regulation of MITF stability by the USP13 deubiquitinase. (PMID: 21811243) Zhao X … Fisher DE (Nature communications 2011) 3 4

Products for USP13 Gene

Sources for USP13 Gene