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Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
USP10 (Ubiquitin Specific Peptidase 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is USP8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002039 | p53 binding | IPI | 20096447 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004197 | cysteine-type endopeptidase activity | IMP | 21962518 |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | TAS | -- |
GO:0005515 | protein binding | IPI | 19398555 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 20096447 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA,IDA | 20096447 |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | IBA,IDA | 19398555 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
2 | Deubiquitination |
.74
|
|
3 | Metabolism of proteins | ||
4 | Apoptosis and Autophagy | ||
5 | DNA Damage |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006281 | DNA repair | IEA | -- |
GO:0006508 | proteolysis | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
GO:0006914 | autophagy | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IMP | 25861989 |
Compound | Action | Cas Number |
---|---|---|
Spautin-1 | Novel autophagy inhibitor | 1262888-28-7 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · | 10h | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - |
ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||
SP13: | - | - | |||||||||||||||||||||||
SP14: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | USP10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | USP10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | USP10 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Usp10 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Usp10 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | USP10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | USP10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp10 30 |
|
||
Str.51 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | usp10-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | usp10 30 31 |
|
OneToOne | |
wufc19h08 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG32479 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP3 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | UBP24 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0661300 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6419 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3287 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv22326 | CNV | loss | 19812545 |
esv2714836 | CNV | deletion | 23290073 |
esv2714837 | CNV | deletion | 23290073 |
esv28029 | CNV | loss | 19812545 |
esv3414928 | CNV | insertion | 20981092 |
nsv1056758 | CNV | gain | 25217958 |
nsv1061271 | CNV | loss | 25217958 |
nsv1066260 | CNV | gain | 25217958 |
nsv483044 | CNV | gain | 15286789 |
nsv510429 | OTHER | sequence alteration | 20534489 |
nsv573465 | CNV | loss | 21841781 |
nsv984359 | CNV | duplication | 23825009 |
No disorders were found for USP10 Gene.