USP10 Gene (Protein Coding)

Ubiquitin Specific Peptidase 10

GC16P084734
GIFtS:
44
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-... See more...

Aliases for USP10 Gene

Aliases for USP10 Gene

  • Ubiquitin Specific Peptidase 10 2 3 5
  • Ubiquitin-Specific-Processing Protease 10 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 10 3 4
  • Ubiquitin Specific Protease 10 2 3
  • Deubiquitinating Enzyme 10 3 4
  • Ubiquitin Thioesterase 10 3 4
  • KIAA0190 2 4
  • UBPO 2 3
  • Ubiquitin Thiolesterase 10 3
  • EC 3.4.19.12 4
  • USP10 5

External Ids for USP10 Gene

Previous GeneCards Identifiers for USP10 Gene

  • GC16M075919
  • GC16P085700
  • GC16P084472
  • GC16P084513
  • GC16P083291
  • GC16P070487

Summaries for USP10 Gene

Entrez Gene Summary for USP10 Gene

  • Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for USP10 Gene

USP10 (Ubiquitin Specific Peptidase 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is USP8.

UniProtKB/Swiss-Prot Summary for USP10 Gene

  • Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).

Gene Wiki entry for USP10 Gene

Additional gene information for USP10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP10 Gene

Genomics for USP10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for USP10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around USP10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP10

Top Transcription factor binding sites by QIAGEN in the USP10 gene promoter:
  • c-Myb
  • Egr-2
  • HTF
  • MyoD
  • POU2F1
  • POU2F1a
  • Sox5
  • YY1

Genomic Locations for USP10 Gene

Genomic Locations for USP10 Gene
chr16:84,699,977-84,779,922
(GRCh38/hg38)
Size:
79,946 bases
Orientation:
Plus strand
chr16:84,733,555-84,813,528
(GRCh37/hg19)
Size:
79,974 bases
Orientation:
Plus strand

Genomic View for USP10 Gene

Genes around USP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for USP10 Gene

Proteins for USP10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for USP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14694-UBP10_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 10
    Protein Accession:
    Q14694
    Secondary Accessions:
    • B2RDJ8
    • B4DS84
    • Q9BWG7
    • Q9NSL7

    Protein attributes for USP10 Gene

    Size:
    798 amino acids
    Molecular mass:
    87134 Da
    Quaternary structure:
    • Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta (IL1B)-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with G3BP1 (via NTF2-like domain) and G3BP2 (via NTF2-like domain) (PubMed:11439350, PubMed:23279204). Interacts with p53/TP53 (PubMed:20096447). Interacts with SNX3 (PubMed:18632802). Interacts with CFTR (PubMed:19398555). Interacts with TBX21 (PubMed:24845384).
    SequenceCaution:
    • Sequence=CAD97644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP10 Gene

Protein Expression for USP10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for USP10 Gene

  • Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.
  • Ubiquitinated. Deubiquitinated by USP13.
  • Ubiquitination at Lys408
  • Modification sites at PhosphoSitePlus

Other Protein References for USP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for USP10
  • Santa Cruz Biotechnology (SCBT) Antibodies for USP10

No data available for DME Specific Peptides for USP10 Gene

Domains & Families for USP10 Gene

Gene Families for USP10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP10 Gene

InterPro:
Blocks:
  • Ubiquitin thiolesterase, family 2
  • Ataxin-2, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for USP10 Gene

GenScript: Design optimal peptide antigens:
  • USP10 protein (Q6P2I0_HUMAN)
  • Ubiquitin-specific-processing protease 10 (UBP10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14694

UniProtKB/Swiss-Prot:

UBP10_HUMAN :
  • Belongs to the peptidase C19 family. USP10 subfamily.
Family:
  • Belongs to the peptidase C19 family. USP10 subfamily.
genes like me logo Genes that share domains with USP10: view

Function for USP10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for USP10 Gene

UniProtKB/Swiss-Prot Function:
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:20096447};.
UniProtKB/Swiss-Prot Induction:
Following DNA damage. Down-regulated in renal cell carcinomas.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes.
GENATLAS Biochemistry:
ubiquitin specific protease 10,deubiquitin enzyme family

Enzyme Numbers (IUBMB) for USP10 Gene

Phenotypes From GWAS Catalog for USP10 Gene

Gene Ontology (GO) - Molecular Function for USP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 20096447
GO:0003723 RNA binding HDA 22658674
GO:0004197 cysteine-type endopeptidase activity IMP 21962518
GO:0004843 thiol-dependent ubiquitin-specific protease activity TAS --
GO:0005515 protein binding IPI 19398555
genes like me logo Genes that share ontologies with USP10: view
genes like me logo Genes that share phenotypes with USP10: view

Animal Models for USP10 Gene

MGI Knock Outs for USP10:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP10

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP10 Gene

Localization for USP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP10 Gene

Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). {ECO:0000269 PubMed:20096447}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP10 gene
Compartment Confidence
nucleus 5
endosome 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20096447
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 20096447
GO:0005768 endosome IEA --
GO:0005769 early endosome IBA,IDA 19398555
genes like me logo Genes that share ontologies with USP10: view

Pathways & Interactions for USP10 Gene

genes like me logo Genes that share pathways with USP10: view

Pathways by source for USP10 Gene

1 Qiagen pathway for USP10 Gene
  • Ubiquitin-Proteasome Dependent Proteolysis
2 Cell Signaling Technology pathways for USP10 Gene

SIGNOR curated interactions for USP10 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for USP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006914 autophagy IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 25861989
genes like me logo Genes that share ontologies with USP10: view

Drugs & Compounds for USP10 Gene

Products:

  1. Drug

(2) Drugs for USP10 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Spautin-1 Pharma Novel autophagy inhibitor 0

(1) ApexBio Compounds for USP10 Gene

Compound Action Cas Number
Spautin-1 Novel autophagy inhibitor 1262888-28-7
genes like me logo Genes that share compounds with USP10: view

Drug Products

Transcripts for USP10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for USP10 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP10

Alternative Splicing Database (ASD) splice patterns (SP) for USP10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - - - - - - -
SP9:
SP10: - - - - - - - -
SP11: -
SP12: -
SP13:
SP14: -

ExUns: 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d
SP1: -
SP2: - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:

Relevant External Links for USP10 Gene

GeneLoc Exon Structure for
USP10

Expression for USP10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP10 Gene

mRNA expression in normal human tissues for USP10 Gene
mRNA expression by GTEx for USP10 GenemRNA expression by BioGPS for USP10 Gene

mRNA differential expression in normal tissues according to GTEx for USP10 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for USP10 Gene

This gene is overexpressed in Pancreas (16.1), Breast (9.7), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP10 Gene



Protein tissue co-expression partners for USP10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP10

SOURCE GeneReport for Unigene cluster for USP10 Gene:

Hs.136778

mRNA Expression by UniProt/SwissProt for USP10 Gene:

Q14694-UBP10_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for USP10 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Eye(4.3)
  • Bone marrow(4.3)
  • Lung(3.3)
  • Kidney(3.1)
  • Intestine(2.5)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with USP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP10 Gene

Orthologs for USP10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia USP10 30 31
  • 99.52 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia USP10 30 31
  • 87.99 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia USP10 30 31
  • 85.55 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Usp10 30
  • 82.37 (n)
Mouse
(Mus musculus)
 Mammalia Usp10 30 17 31
  • 81.33 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 81 (a)
 OneToMany
-- 31
  • 76 (a)
 OneToMany
-- 31
  • 75 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia USP10 31
  • 79 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves USP10 30 31
  • 78.42 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 93 (a)
 OneToMany
-- 31
  • 68 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia usp10 30
  • 72.06 (n)
Str.51 30
African clawed frog
(Xenopus laevis)
 Amphibia usp10-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii usp10 30 31
  • 63.42 (n)
 OneToOne
wufc19h08 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG32479 31
  • 13 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes UBP3 31 33
  • 16 (a)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons UBP24 30
  • 49.62 (n)
Rice
(Oryza sativa)
 Liliopsida Os07g0661300 30
  • 48.35 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.6419 31
  • 45 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.3287 30
Species where no ortholog for USP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for USP10 Gene

ENSEMBL:
Gene Tree for USP10 (if available)
TreeFam:
Gene Tree for USP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USP10: view image

Paralogs for USP10 Gene

Paralogs for USP10 Gene

(54) SIMAP similar genes for USP10 Gene using alignment to 10 proteins:

  • UBP10_HUMAN
  • H3BNA1_HUMAN
  • H3BNL0_HUMAN
  • H3BNP1_HUMAN
  • H3BNS8_HUMAN
  • H3BQC6_HUMAN
  • H3BQP1_HUMAN
  • H3BVF1_HUMAN
  • J3KT19_HUMAN
  • Q6P2I0_HUMAN

Pseudogenes.org Pseudogenes for USP10 Gene

genes like me logo Genes that share paralogs with USP10: view

Variants for USP10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP10 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1812061 - p.Val204Leu
rs1862792 - p.Met200Val
rs2326391 - p.Ser203Pro

Additional dbSNP identifiers (rs#s) for USP10 Gene

Structural Variations from Database of Genomic Variants (DGV) for USP10 Gene

Variant ID Type Subtype PubMed ID
esv22326 CNV loss 19812545
esv2714836 CNV deletion 23290073
esv2714837 CNV deletion 23290073
esv28029 CNV loss 19812545
esv3414928 CNV insertion 20981092
nsv1056758 CNV gain 25217958
nsv1061271 CNV loss 25217958
nsv1066260 CNV gain 25217958
nsv483044 CNV gain 15286789
nsv510429 OTHER sequence alteration 20534489
nsv573465 CNV loss 21841781
nsv984359 CNV duplication 23825009

Variation tolerance for USP10 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP10 Gene

Human Gene Mutation Database (HGMD)
USP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP10 Gene

Disorders for USP10 Gene

Additional Disease Information for USP10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for USP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP10 Gene

Publications for USP10 Gene

  1. The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. (PMID: 19398555) Bomberger JM … Stanton BA (The Journal of biological chemistry 2009) 3 4 23
  2. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. (PMID: 25861989) Wang W … Wu ZH (The Journal of biological chemistry 2015) 3 4
  3. Deubiquitination and stabilization of T-bet by USP10. (PMID: 24845384) Pan L … Shi G (Biochemical and biophysical research communications 2014) 3 4
  4. Both G3BP1 and G3BP2 contribute to stress granule formation. (PMID: 23279204) Matsuki H … Fujii M (Genes to cells : devoted to molecular & cellular mechanisms 2013) 3 4
  5. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PMID: 21962518) Liu J … Yuan J (Cell 2011) 3 4

ExternalLinks

View latest publications for USP10 gene in Mastermind

Products for USP10 Gene

  • Addgene plasmids for USP10

Sources for USP10 Gene