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Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-... See more...
Aliases for USP10 Gene
Aliases for USP10 Gene
External Ids for USP10 Gene
- HGNC: 12608
- Entrez Gene: 9100
- Ensembl: ENSG00000103194
- OMIM: 609818
- UniProtKB: Q14694
Previous GeneCards Identifiers for USP10 Gene
- GC16M075919
- GC16P085700
- GC16P084472
- GC16P084513
- GC16P083291
- GC16P070487
Summaries for USP10 Gene
-
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
GeneCards Summary for USP10 Gene
USP10 (Ubiquitin Specific Peptidase 10) is a Protein Coding gene. Diseases associated with USP10 include Small Intestine Adenocarcinoma and Small Intestine Cancer. Among its related pathways are Apoptosis and Autophagy and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is USP19.
UniProtKB/Swiss-Prot Summary for USP10 Gene
-
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP10 Gene
Genomics for USP10 Gene
GeneHancer (GH) Regulatory Elements for USP10 Gene
Promoters and enhancers for USP10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around USP10 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the USP10 gene promoter:
-
- c-Myb
- Egr-2
- HTF
- MyoD
- POU2F1
- POU2F1a
- Sox5
- YY1
Genomic Locations for USP10 Gene
Genomic Locations for USP10 Gene
- chr16:84,699,949-84,779,922
- (GRCh38/hg38)
- Size:
- 79,974 bases
- Orientation:
- Plus strand
- chr16:84,733,555-84,813,528
- (GRCh37/hg19)
- Size:
- 79,974 bases
- Orientation:
- Plus strand
Genomic View for USP10 Gene
Genes around USP10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.1 by HGNC
- 16q24.1 by Entrez Gene
- 16q24.1 by Ensembl
USP10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for USP10 Gene
Proteins for USP10 Gene
-
Protein details for USP10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14694-UBP10_HUMAN
- Recommended name:
- Ubiquitin carboxyl-terminal hydrolase 10
- Protein Accession:
- Q14694
- B2RDJ8
- B4DS84
- Q9BWG7
- Q9NSL7
Protein attributes for USP10 Gene
- Size:
- 798 amino acids
- Molecular mass:
- 87134 Da
- Quaternary structure:
-
- Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta (IL1B)-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with G3BP1 (via NTF2-like domain) and G3BP2 (via NTF2-like domain) (PubMed:11439350, PubMed:23279204). Interacts with p53/TP53 (PubMed:20096447). Interacts with SNX3 (PubMed:18632802). Interacts with CFTR (PubMed:19398555). Interacts with TBX21 (PubMed:24845384).
- SequenceCaution:
-
- Sequence=CAD97644.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for USP10 Gene
Post-translational modifications for USP10 Gene
- Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.
- Ubiquitinated. Deubiquitinated by USP13.
-
Ubiquitination at Lys408
- NX_Q14694 (NX_Q14694-1)
- Modification sites at PhosphoSitePlus
Other Protein References for USP10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ USP10 Antibody
- Atlas Antibodies Anti-USP10 Antibody (HPA006749) and Anti-USP10 Antibody (HPA006731)
- Creative Diagnostics Anti-USP10 monoclonal antibody, clone 3F2 and Rabbit Anti-Human USP10 Polyclonal antibody
-
Creative Biolabs
- Mouse Anti-USP10 Recombinant Antibody (2E1)
- Mouse Anti-USP10 Recombinant Antibody (1H9)
- Mouse Anti-USP10 Recombinant Antibody (1A10)
- Hi-Affi™ Recombinant Rabbit Anti-USP10 Monoclonal Antibody (DS3802AB)
- Mouse Anti-USP10 (aa 699-797) Recombinant Antibody (3B8)
- Mouse Anti-USP10 Recombinant Antibody (CBXU-065)
- Rabbit Anti-USP10 Recombinant Antibody (CBXU-157)
- Mouse Anti-USP10 Recombinant Antibody (CBXU-006)
- Recombinant Mouse anti-Human USP10 Monoclonal antibody (EML870)
- Rabbit Anti-USP10 Recombinant Antibody (CBXU-028)
- Mouse Anti-USP10 Recombinant Antibody (CBXU-066)
-
Custom Antibody ServicesOriGene Antibodies for USP10
- Novus Biologicals Antibodies for USP10
-
Abcam antibodies for USP10
- Invitrogen Antibodies for USP10 (AFLGC-USP10)
-
Biorbyt antibodies for USP10
-
Boster Bio Antibodies for USP10
-
Custom Antibody ServicesProSci Antibodies for USP10
-
Santa Cruz Biotechnology (SCBT) Antibodies for USP10
Protein Products
- Atlas Antibodies PrEST Antigen USP10 (APrEST70789) and PrEST Antigen USP10 (APrEST70790)
-
OriGene Purified Proteins for USP10
- Search Origene for MassSpec and Protein Over-expression Lysates for USP10
- Origene Custom Protein Services for USP10
- antibodies-online: Show 4 available USP10 Proteins ranked by validation data
- Compare Top USP10 Proteins
-
Quality Products:
-
Abcam proteins for USP10
No data available for DME Specific Peptides for USP10 Gene
Domains & Families for USP10 Gene
Gene Families for USP10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for USP10 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for USP10 Gene
- GenScript: Design optimal peptide antigens:
-
- USP10 protein (Q6P2I0_HUMAN)
- Ubiquitin-specific-processing protease 10 (UBP10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14694- Family:
-
- Belongs to the peptidase C19 family. USP10 subfamily.
Function for USP10 Gene
Molecular function for USP10 Gene
- UniProtKB/Swiss-Prot Function:
- Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence=. ;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes.
- UniProtKB/Swiss-Prot Induction:
- Following DNA damage. Down-regulated in renal cell carcinomas.
- GENATLAS Biochemistry:
- ubiquitin specific protease 10,deubiquitin enzyme family
Enzyme Numbers (IUBMB) for USP10 Gene
Phenotypes From GWAS Catalog for USP10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002039 | p53 binding | IPI | 20096447 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004197 | cysteine-type endopeptidase activity | IMP | 21962518 |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 19398555 |
Phenotypes for USP10 Gene
- MGI mutant phenotypes for USP10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for USP10:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Dynamic nuclei (hole, folded or small irregular)
- Increased cell death HMECs cells
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
Animal Models for USP10 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for USP10
CRISPR Products
-
OriGene CRISPR knockouts for USP10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP10
- genomics-online: gRNA clones - Search for available USP10 gRNA products
- Overview of 136 available USP10 gene related products
- Applied Biological Materials (abm): CRISPR Clones for USP10 - Select products 50% OFF >
- * USP10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * USP10 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP10
miRNA for USP10 Gene
- miRTarBase miRNAs that target USP10
-
- hsa-mir-375 (MIRT019670)
- hsa-mir-124-3p (MIRT022173)
- hsa-mir-122-5p (MIRT023247)
- hsa-mir-98-5p (MIRT027416)
- hsa-mir-24-3p (MIRT030377)
- hsa-let-7b-5p (MIRT032235)
- hsa-mir-455-3p (MIRT037849)
- hsa-mir-652-3p (MIRT039563)
- hsa-mir-181b-5p (MIRT047239)
- hsa-mir-92a-3p (MIRT049080)
- hsa-mir-20a-5p (MIRT050557)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for USP10
- Browse OriGene Inhibitory RNA Products For USP10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP10
- genomics-online: shRNA clones - Search for available USP10 shRNA products
- Overview of 136 available USP10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for USP10
- Addgene plasmids for USP10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP10
- genomics-online: cdna clones - Search for available USP10 CDNA products
- Overview of 136 available USP10 gene related products
- orf clones - Search for available USP10 ORF products
- Overview of 136 available USP10 gene related products
- Applied Biological Materials (abm): Clones for USP10 - Select products 50% OFF >
- * USP10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * USP10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for USP10
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP10 Gene
Localization for USP10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for USP10 Gene
- Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). {ECO:0000269 PubMed:20096447}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 20096447 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 20096447 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IDA,IBA | 19398555 |
Pathways & Interactions for USP10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
| 2 | Deubiquitination |
.74
|
|
| 3 | Metabolism of proteins | ||
| 4 | Apoptosis and Autophagy | ||
| 5 | DNA Damage | ||
Pathways by source for USP10 Gene
8 Reactome pathways for USP10 Gene
1 Qiagen pathway for USP10 Gene
- Ubiquitin-Proteasome Dependent Proteolysis
2 Cell Signaling Technology pathways for USP10 Gene
Interacting Proteins for USP10 Gene
Selected Interacting proteins:
Q14694-UBP10_HUMAN
ENSP00000457411
for USP10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for USP10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0006914 | autophagy | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 25861989 |
No data available for SIGNOR curated interactions for USP10 Gene
Drugs & Compounds for USP10 Gene
(1) ApexBio Compounds for USP10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Spautin-1 | Novel autophagy inhibitor | 1262888-28-7 |
Drug Products
- Atlas Antibodies PrEST Antigen USP10 (APrEST70789) and PrEST Antigen USP10 (APrEST70790)
- ApexBio compounds for USP10
Transcripts for USP10 Gene
mRNA/cDNA for USP10 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (354) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000219473 3009 bps (ENST00000219473.11)
- ENST00000540269 3070 bps (ENST00000540269.6)
- ENST00000562092 254 bps (ENST00000562092.1)
- ENST00000562283 569 bps (ENST00000562283.5)
- ENST00000562743 888 bps (ENST00000562743.5)
CRISPR Products
-
OriGene CRISPR knockouts for USP10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP10
- genomics-online: gRNA clones - Search for available USP10 gRNA products
- Overview of 136 available USP10 gene related products
- Applied Biological Materials (abm): CRISPR Clones for USP10 - Select products 50% OFF >
- * USP10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * USP10 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP10
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for USP10
- Browse OriGene Inhibitory RNA Products For USP10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP10
- genomics-online: shRNA clones - Search for available USP10 shRNA products
- Overview of 136 available USP10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for USP10
- Addgene plasmids for USP10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP10
- genomics-online: cdna clones - Search for available USP10 CDNA products
- Overview of 136 available USP10 gene related products
- orf clones - Search for available USP10 ORF products
- Overview of 136 available USP10 gene related products
- Applied Biological Materials (abm): Clones for USP10 - Select products 50% OFF >
- * USP10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * USP10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · | 10h | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - |
| ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||
| SP13: | - | - | |||||||||||||||||||||||
| SP14: |
Expression for USP10 Gene
mRNA differential expression in normal tissues according to GTEx for USP10 Gene
This gene is overexpressed in Whole Blood (x5.0).
This gene is overexpressed in Pancreas (16.1), Breast (9.7), and Peripheral blood mononuclear cells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of USP10 Gene:
USP10SOURCE GeneReport for Unigene cluster for USP10 Gene:
Hs.136778mRNA Expression by UniProt/SwissProt for USP10 Gene:
Q14694-UBP10_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for USP10 Gene
- Nervous system(5)
- Eye(4.3)
- Liver(4.3)
- Bone marrow(4.2)
- Lung(3.1)
- Kidney(2.5)
Primer Products
-
OriGene qPCR primer pairs for USP10
-
OriGene qPCR primer pairs and template standards for USP10
- genomics-online: primer clones - Search for available USP10 Primer products
- Overview of 136 available USP10 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP10 Gene
Orthologs for USP10 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | USP10 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | USP10 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | USP10 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Usp10 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Usp10 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | USP10 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | USP10 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | usp10 32 |
|
||
| Str.51 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | usp10-prov 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | usp10 33 32 |
|
OneToOne | |
| wufc19h08 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32479 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP3 35 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | UBP24 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0661300 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6419 33 |
|
OneToOne | |
| Cin.3287 32 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3287 32 |
|
- Species where no ortholog for USP10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for USP10 Gene
- ENSEMBL:
- Gene Tree for USP10 (if available)
- TreeFam:
- Gene Tree for USP10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for USP10: view image
Paralogs for USP10 Gene
Paralogs for USP10 Gene
- USP19 5
- USP33 5
- USP8 5
- USP20 5
- USP4 5
- USP15 5
- USP38 5
- USP9X 5
- USP51 5
- USP11 5
- USP24 5
- USP9Y 5
- USP35 5
- USP22 5
- USP49 5
- USP36 5
- USP16 5
- USP37 5
- USP44 5
- USP43 5
- USP29 5
- USP2 5
- USP3 5
- USP30 5
- USP27X 5
- USP26 5
- USP48 5
- USP42 5
- USP17L19 5
- USP34 5
- USP31 5
- USP7 5
- USP17L11 5
- USP17L8 5
- USP17L29 5
- USP17L26 5
- USP17L13 5
- USP17L15 5
- USP17L25 5
- USP17L22 5
- USP17L2 5
- USP17L21 5
- USP5 5
- USP17L28 5
- USP17L10 5
- USP17L30 5
- USP17L4 5
- USP17L24 5
- USP13 5
- USP21 5
- USP17L12 5
- USP45 5
- USP17L17 5
- USP1 5
- USP17L27 5
- USP17L3 5
- USP17L20 5
- USP17L5 5
- USP17L18 5
- USP14 5
- USP17L1 5
- USP17L7 5
- USP50 5
- USP47 5
- USP28 5
- USP40 5
- USP18 5
- USP32 5
- USP41 5
- USP25 5
- USP6 5
- USP17L23 5
(54) SIMAP similar genes for USP10 Gene using alignment to 10 proteins:
- UBP10_HUMAN
- H3BNA1_HUMAN
- H3BNL0_HUMAN
- H3BNP1_HUMAN
- H3BNS8_HUMAN
- H3BQC6_HUMAN
- H3BQP1_HUMAN
- H3BVF1_HUMAN
- J3KT19_HUMAN
- Q6P2I0_HUMAN
- DKFZp686E14181
- DCTN5
- AURA2
- LYRM4
- UTY
- BTBD2
- FOPNL
- FAM210A
- NF2
- CHID1
- ZNF737
- ZNF564
- ZNF212
- ZNF585B
- UBIAD1
- ERBB2
- CATSPERG
- SEPT2
- CTSS
- ZNF738
- MPP4
- DNMT1
- ASB11
- DNAPTP3
- PKN1
- RNF217
- PLEKHH2
- NRAMP1
- EIF3L
- KDM5B
- GLT8D2
- FKBP3
- ZNF461
- GCDH
- DAPL1
- ATP6V0A1
- FAM175A
- APOD
- ZNF547
- HAUS1
- ZNF816
- ZNF28
- ZNF611
- HKR1
- TCF4
- ZNF283
- NEK4
- NPLOC4
- SNX31
- NSRP1
- ZNF468
- ZNF763
- TIMM23B
- USP8
Pseudogenes.org Pseudogenes for USP10 Gene
Variants for USP10 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001568 | -- | 84,779,005(+) | A/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000010798 | -- | 84,735,656(+) | A/G | intron_variant | |
| rs1000013148 | -- | 84,709,409(+) | C/G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000036949 | -- | 84,708,113(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000141000 | -- | 84,712,522(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22326 | CNV | loss | 19812545 |
| esv2714836 | CNV | deletion | 23290073 |
| esv2714837 | CNV | deletion | 23290073 |
| esv28029 | CNV | loss | 19812545 |
| esv3414928 | CNV | insertion | 20981092 |
| nsv1056758 | CNV | gain | 25217958 |
| nsv1061271 | CNV | loss | 25217958 |
| nsv1066260 | CNV | gain | 25217958 |
| nsv483044 | CNV | gain | 15286789 |
| nsv510429 | OTHER | sequence alteration | 20534489 |
| nsv573465 | CNV | loss | 21841781 |
| nsv984359 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.23;
84.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for USP10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP10 Gene
Disorders for USP10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| small intestine adenocarcinoma |
|
|
| small intestine cancer |
|
|
Search USP10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for USP10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for USP10 Gene
Publications for USP10 Gene
- The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. (PMID: 19398555) Bomberger JM … Stanton BA (The Journal of biological chemistry 2009) 3 4 23 56
- TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. (PMID: 25861989) Wang W … Wu ZH (The Journal of biological chemistry 2015) 3 4 56
- Deubiquitination and stabilization of T-bet by USP10. (PMID: 24845384) Pan L … Shi G (Biochemical and biophysical research communications 2014) 3 4 56
- Both G3BP1 and G3BP2 contribute to stress granule formation. (PMID: 23279204) Matsuki H … Fujii M (Genes to cells : devoted to molecular & cellular mechanisms 2013) 3 4 56
- Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PMID: 21962518) Liu J … Yuan J (Cell 2011) 3 4 56
ExternalLinks
Products for USP10 Gene
- Custom Antibody ServicesOriGene Antibodies for USP10
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for USP10
- Search Origene for MassSpec and Protein Over-expression Lysates for USP10
- Origene Custom Protein Services for USP10
- Origene sirna, shrna, and RNAi products in human, mouse, rat for USP10
- Browse OriGene Inhibitory RNA Products For USP10
- OriGene qPCR primer pairs for USP10
- OriGene qPCR primer pairs and template standards for USP10
- OriGene CRISPR knockouts for USP10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For USP10
- Sino Biological Human cDNA Clone for USP10
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for USP10
- Novus Biologicals proteins and lysates for USP10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for USP10
- Abcam proteins for USP10
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for USP10
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for USP10 (AFLGC-USP10)
- ApexBio compounds for USP10
- Addgene plasmids for USP10
- antibodies-online: Show 34 available USP10 Antibodies ranked by validation data
- Compare Top USP10 Antibodies
- antibodies-online: Search results for available USP10 related products ranked by validation data
- antibodies-online: Show 4 available USP10 Proteins ranked by validation data
- Compare Top USP10 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for USP10
- Search Santa Cruz Biotechnology (SCBT) for USP10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for USP10
- Custom Antibody ServicesProSci Antibodies for USP10
- Search for USP10 Proteins at ProSci
- Horizon Cell Lines for USP10
- genomics-online: cdna clones - Search for available USP10 CDNA products
- Overview of 136 available USP10 gene related products
- orf clones - Search for available USP10 ORF products
- Overview of 136 available USP10 gene related products
- genomics-online: gRNA clones - Search for available USP10 gRNA products
- Overview of 136 available USP10 gene related products
- genomics-online: primer clones - Search for available USP10 Primer products
- Overview of 136 available USP10 gene related products
- genomics-online: shRNA clones - Search for available USP10 shRNA products
- Overview of 136 available USP10 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for USP10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP10
- Boster Bio Antibodies for USP10
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for USP10
Sources for USP10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource