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Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
USP10 (Ubiquitin Specific Peptidase 10) is a Protein Coding gene. Diseases associated with USP10 include Small Intestine Adenocarcinoma and Small Intestine Cancer. Among its related pathways are Apoptosis and Autophagy and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is USP19.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002039 | p53 binding | IPI | 20096447 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004197 | cysteine-type endopeptidase activity | IMP | 21962518 |
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | TAS | -- |
GO:0005515 | protein binding | IPI | 19398555 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 20096447 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA,IDA | 20096447 |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | IDA,IBA | 19398555 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
2 | Deubiquitination |
.74
|
|
3 | Metabolism of proteins | ||
4 | Apoptosis and Autophagy | ||
5 | DNA Damage |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006281 | DNA repair | IEA | -- |
GO:0006508 | proteolysis | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
GO:0006914 | autophagy | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IMP | 25861989 |
Compound | Action | Cas Number |
---|---|---|
Spautin-1 | Novel autophagy inhibitor | 1262888-28-7 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · | 10h | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - |
ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||
SP13: | - | - | |||||||||||||||||||||||
SP14: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | USP10 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | USP10 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | USP10 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Usp10 32 |
|
||
mouse (Mus musculus) |
Mammalia | Usp10 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
-- 33 |
|
OneToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | USP10 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | USP10 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | usp10 32 |
|
||
Str.51 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | usp10-prov 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | usp10 33 32 |
|
OneToOne | |
wufc19h08 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG32479 33 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP3 35 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | UBP24 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os07g0661300 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6419 33 |
|
OneToOne | |
Cin.3287 32 |
|
||||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3287 32 |
|
SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000001568 | -- | 84,779,005(+) | A/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1000010798 | -- | 84,735,656(+) | A/G | intron_variant | |
rs1000013148 | -- | 84,709,409(+) | C/G/T | genic_upstream_transcript_variant, intron_variant | |
rs1000036949 | -- | 84,708,113(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000141000 | -- | 84,712,522(+) | C/T | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv22326 | CNV | loss | 19812545 |
esv2714836 | CNV | deletion | 23290073 |
esv2714837 | CNV | deletion | 23290073 |
esv28029 | CNV | loss | 19812545 |
esv3414928 | CNV | insertion | 20981092 |
nsv1056758 | CNV | gain | 25217958 |
nsv1061271 | CNV | loss | 25217958 |
nsv1066260 | CNV | gain | 25217958 |
nsv483044 | CNV | gain | 15286789 |
nsv510429 | OTHER | sequence alteration | 20534489 |
nsv573465 | CNV | loss | 21841781 |
nsv984359 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
small intestine adenocarcinoma |
|
|
small intestine cancer |
|
|