Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair... See more...
Aliases for USP1 Gene
Aliases for USP1 Gene
External Ids for USP1 Gene
- HGNC: 12607
- NCBI Entrez Gene: 7398
- Ensembl: ENSG00000162607
- OMIM®: 603478
- UniProtKB/Swiss-Prot: O94782
Previous GeneCards Identifiers for USP1 Gene
- GC01P062837
- GC01P061825
- GC01P062259
- GC01P062272
- GC01P062614
- GC01P062674
- GC01P061014
Summaries for USP1 Gene
-
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for USP1 Gene
USP1 (Ubiquitin Specific Peptidase 1) is a Protein Coding gene. Diseases associated with USP1 include Fanconi Anemia, Complementation Group I and Mast Syndrome. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and miR-517 relationship with ARCN1 and USP1. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP8.
UniProtKB/Swiss-Prot Summary for USP1 Gene
-
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Additional gene information for USP1 Gene
- HGNC (12607)
- NCBI Entrez Gene (7398)
- Ensembl (ENSG00000162607)
- OMIM® (603478)
- UniProtKB/Swiss-Prot (O94782)
- Open Targets Platform(ENSG00000162607)
- Search for USP1 at DataMed
- Search for USP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for USP1 Gene
Genomics for USP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for USP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around USP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for USP1
- Top Transcription factor binding sites by QIAGEN in the USP1 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- HFH-1
Genomic Locations for USP1 Gene
Latest Assembly
- chr1:62,436,297-62,451,804
- (GRCh38/hg38)
- Size:
- 15,508 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:62,902,066-62,917,475
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 15,410 bases
- Orientation:
- Plus strand
- chr1:62,901,968-62,917,475
- (GRCh37/hg19 by Ensembl)
- Size:
- 15,508 bases
- Orientation:
- Plus strand
Genomic View for USP1 Gene
Genes around USP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
USP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for USP1 Gene
Proteins for USP1 Gene
-
Protein details for USP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94782-UBP1_HUMAN
- Recommended name:
- Ubiquitin carboxyl-terminal hydrolase 1
- Protein Accession:
- O94782
- A0PJ95
- D3DQ57
- Q05BX7
- Q59H66
- Q9UFR0
- Q9UNJ3
Protein attributes for USP1 Gene
- Size:
- 785 amino acids
- Molecular mass:
- 88207 Da
- Quaternary structure:
-
- Interacts with FANCD2 and PCNA (PubMed:15694335, PubMed:16531995). Interacts with WDR48 (PubMed:18082604, PubMed:26388029).
- SequenceCaution:
-
- Sequence=AAH18745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32364.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD92130.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.
Protein Expression for USP1 Gene
Selected DME Specific Peptides for USP1 Gene
- O94782:
-
- KQPSILSKFCS
- EENQRQTRSKRKA
Post-translational modifications for USP1 Gene
- Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
- Ubiquitinated; leading to its subsequent proteasomal degradation.
-
Ubiquitination at Lys73, Lys110, Lys689, Lys746, and Lys761
- NX_O94782 (NX_O94782-1)
- Modification sites at PhosphoSitePlus
Other Protein References for USP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ USP1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for USP1
- Novus Biologicals Antibodies for USP1
-
Abcam antibodies for USP1
- Invitrogen Antibodies for USP1 (AFLGC-USP1)
-
Boster Bio Antibodies for USP1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for USP1
- Origene Custom Protein Services for USP1
- antibodies-online: Show 7 available USP1 Proteins ranked by validation data
- Compare Top USP1 Proteins
-
Quality Products:
-
Abcam proteins for USP1
Assay products for research
- antibodies-online: Search results for available USP1 related products ranked by validation data
Domains & Families for USP1 Gene
Gene Families for USP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for USP1 Gene
- InterPro:
- Blocks:
-
- Ubiquitin thiolesterase, family 2
- ProtoNet:
Suggested Antigen Peptide Sequences for USP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-specific-processing protease 1 (UBP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O94782- Family:
-
- Belongs to the peptidase C19 family.
Function for USP1 Gene
Molecular function for USP1 Gene
- UniProtKB/Swiss-Prot Function:
- Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:9806842};.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated following DNA damage.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.7 uM for ubiquitin vinyl sulfone (in presence of WDR48) {ECO:0000269|PubMed:18082604}; KM=1.4 uM for ubiquitin vinyl sulfone (in absence of WDR48) {ECO:0000269|PubMed:18082604};
- GENATLAS Biochemistry:
- ubiquitin-specific protease 1,88.2kDa,ubiquitin specific processing family member,involved in cleavage beta galactosidase,deubiquitin enzyme family
Enzyme Numbers (IUBMB) for USP1 Gene
Phenotypes From GWAS Catalog for USP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004197 | cysteine-type endopeptidase activity | TAS,IBA | 21873635 |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity | TAS,IMP | 20129063 |
| GO:0005515 | protein binding | IPI | 18082604 |
| GO:0008233 | peptidase activity | EXP | 16531995 |
| GO:0008234 | cysteine-type peptidase activity | IEA | -- |
Phenotypes for USP1 Gene
- MGI mutant phenotypes for USP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for USP1:
-
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased ionizing radiation sensitivity
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 25%
- Decreased viability in ovarian lineage
- Decreased viability after Maraba virus infection
- Two nuclei (binuclear)
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased hepcidin::fluc mRNA expression
- Increased cell death HMECs cells
- Increased circadian period length
- Increased ionizing radiation sensitivity
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased caspase 3/7 activity
- Increased nuclear migration distance, increased nuclear migration speed
Animal Models for USP1 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for USP1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for USP1 - Starting at $85 >
- * USP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for USP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP1
miRNA for USP1 Gene
- miRTarBase miRNAs that target USP1
-
- mmu-miR-375-3p (MIRT001668)
- hsa-miR-375 (MIRT001747)
- hsa-miR-215-5p (MIRT024602)
- hsa-miR-192-5p (MIRT026803)
- hsa-miR-100-5p (MIRT048468)
- hsa-let-7f-2-3p (MIRT074510)
- hsa-miR-517a-3p (MIRT074511)
- hsa-miR-517b-3p (MIRT074512)
- hsa-miR-517c-3p (MIRT074513)
- hsa-miR-625-3p (MIRT074514)
- hsa-miR-1185-2-3p (MIRT074515)
- hsa-miR-1185-1-3p (MIRT074516)
- hsa-miR-298 (MIRT074517)
- hsa-miR-4424 (MIRT074518)
- hsa-miR-4517 (MIRT074519)
- hsa-miR-1262 (MIRT343405)
- hsa-miR-4701-3p (MIRT343412)
- hsa-miR-6736-5p (MIRT343414)
- hsa-miR-4536-3p (MIRT529626)
- hsa-miR-5683 (MIRT529627)
- hsa-miR-7641 (MIRT629664)
- hsa-miR-640 (MIRT629665)
- hsa-miR-378a-5p (MIRT629666)
- hsa-miR-4695-3p (MIRT629667)
- hsa-miR-6821-3p (MIRT629668)
- hsa-miR-6790-3p (MIRT629669)
- hsa-miR-1976 (MIRT629670)
- hsa-miR-3653-5p (MIRT629671)
- hsa-miR-575 (MIRT629672)
- hsa-miR-4676-5p (MIRT629673)
- hsa-miR-6858-3p (MIRT629674)
- hsa-miR-7703 (MIRT632258)
- hsa-miR-6720-5p (MIRT632259)
- hsa-miR-6512-3p (MIRT632260)
- hsa-miR-542-3p (MIRT632261)
- hsa-miR-661 (MIRT632262)
- hsa-miR-6776-5p (MIRT632263)
- hsa-miR-4793-3p (MIRT632264)
- hsa-miR-766-3p (MIRT632265)
- hsa-miR-6742-3p (MIRT632266)
- hsa-miR-6849-3p (MIRT632267)
- hsa-miR-508-5p (MIRT632268)
- hsa-miR-1226-3p (MIRT651844)
- hsa-miR-1247-3p (MIRT761588)
- hsa-miR-25-5p (MIRT764264)
- hsa-miR-3160-3p (MIRT765152)
- hsa-miR-4327 (MIRT768691)
- hsa-miR-4487 (MIRT769690)
- hsa-miR-455-3p (MIRT770461)
- hsa-miR-4649-3p (MIRT770689)
- hsa-miR-4722-5p (MIRT771601)
- hsa-miR-558 (MIRT774861)
- hsa-miR-6087 (MIRT775713)
- hsa-miR-6499-3p (MIRT776406)
- hsa-miR-6516-5p (MIRT777252)
- hsa-miR-665 (MIRT777641)
- hsa-miR-6808-5p (MIRT779731)
- hsa-miR-6893-5p (MIRT781263)
- hsa-miR-7160-5p (MIRT781653)
- hsa-miR-940 (MIRT782956)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP1
- Browse OriGene Inhibitory RNA Products For USP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP1
Clone products for research
- Applied Biological Materials (abm): Clones for USP1 - Starting at $45 >
- * USP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- RC208487
- RC208487L1
- RC208487L2
- RC208487L3
- RC208487L4
- RC218192
- RC218192L3
- RC218192L4
- RC218309
- RC218309L1
- RC218309L2
- RC218309L3
- RC218309L4
- RG208487
- RG218192
- RG218309
- RR214933
- RR214933L3
- RR214933L4
- MR210640L3V
- MR210640L4V
- RC208487L1V
- RC208487L2V
- RC208487L3V
- RC208487L4V
- RC218192L3V
- RC218192L4V
- RC218309L1V
- RC218309L2V
- RC218309L3V
- RC218309L4V
- RR214933L3V
- RR214933L4V
- MG210640
- MR210640
- MR210640L3
- MR210640L4
- MR231140
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for USP1
- Addgene plasmids for USP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP1 Gene
Localization for USP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for USP1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 18082604 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IBA | 21873635 |
Pathways & Interactions for USP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fanconi anemia pathway | ||
| 2 | DNA Damage | ||
| 3 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
-
|
|
| 4 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
| 5 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for USP1 Gene
1 BioSystems pathway for USP1 Gene
4 Reactome pathways for USP1 Gene
1 KEGG pathway for USP1 Gene
1 GeneGo (Thomson Reuters) pathway for USP1 Gene
- DNA damage_ATM/ATR regulation of G1/S checkpoint
1 Qiagen pathway for USP1 Gene
- Ubiquitin-Proteasome Dependent Proteolysis
1 Cell Signaling Technology pathway for USP1 Gene
Interacting Proteins for USP1 Gene
Selected Interacting proteins:
O94782-UBP1_HUMAN
ENSP00000343526
for USP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for USP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006282 | regulation of DNA repair | IDA | 18082604 |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
Drugs & Compounds for USP1 Gene
(4) ApexBio Compounds for USP1 Gene
Transcripts for USP1 Gene
mRNA/cDNA for USP1 Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000339950 3602 nts (view in UCSC)
- ENST00000371146 3507 nts (view in UCSC)
- ENST00000442679 502 nts (view in UCSC)
- ENST00000452143 893 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for USP1 - Starting at $85 >
- * USP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for USP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for USP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP1
- Browse OriGene Inhibitory RNA Products For USP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP1
Clone products for research
- Applied Biological Materials (abm): Clones for USP1 - Starting at $45 >
- * USP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- RC208487
- RC208487L1
- RC208487L2
- RC208487L3
- RC208487L4
- RC218192
- RC218192L3
- RC218192L4
- RC218309
- RC218309L1
- RC218309L2
- RC218309L3
- RC218309L4
- RG208487
- RG218192
- RG218309
- RR214933
- RR214933L3
- RR214933L4
- MR210640L3V
- MR210640L4V
- RC208487L1V
- RC208487L2V
- RC208487L3V
- RC208487L4V
- RC218192L3V
- RC218192L4V
- RC218309L1V
- RC218309L2V
- RC218309L3V
- RC218309L4V
- RR214933L3V
- RR214933L4V
- MG210640
- MR210640
- MR210640L3
- MR210640L4
- MR231140
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for USP1
- Addgene plasmids for USP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP1
Relevant External Links for USP1 Gene
- GeneLoc Exon Structure for
- USP1
Expression for USP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- Primordial Germ Cells Allantois
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Thyroid (Endocrine System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
This gene is overexpressed in Serum (40.3) and Liver (24.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for USP1
SOURCE GeneReport for Unigene cluster for USP1 Gene:
Hs.35086Evidence on tissue expression from TISSUES for USP1 Gene
- Nervous system(5)
- Eye(4.8)
- Intestine(4.7)
- Thyroid gland(4.6)
- Lung(4.4)
- Pancreas(4.4)
- Kidney(4.2)
- Skin(3.9)
- Liver(3.9)
- Stomach(3.2)
- Blood(3)
- Bone(2.5)
- Spleen(2.1)
- Bone marrow(2.1)
- Muscle(2)
Primer products for research
-
OriGene qPCR primer pairs for USP1
-
OriGene qPCR primer pairs and template standards for USP1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP1 Gene
Orthologs for USP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | USP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | USP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | USP1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Usp1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Usp1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | USP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | USP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | USP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | USP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | usp1 30 |
|
||
| Str.2887 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398530 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | usp1 30 31 |
|
OneToOne | |
| wufb43a02 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG15817 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP9 31 |
|
ManyToMany | |
| UBP13 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for USP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for USP1 Gene
- ENSEMBL:
- Gene Tree for USP1 (if available)
- TreeFam:
- Gene Tree for USP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for USP1: view image
Paralogs for USP1 Gene
Paralogs for USP1 Gene
- USP8 5
- USP19 5
- USP4 5
- USP45 5
- USP33 5
- USP16 5
- USP31 5
- USP49 5
- USP20 5
- USP15 5
- USP38 5
- USP2 5
- USP11 5
- USP51 5
- USP48 5
- USP22 5
- USP24 5
- USP10 5
- USP35 5
- USP44 5
- USP32 5
- USP21 5
- USP42 5
- USP27X 5
- USP17L12 5
- USP17L21 5
- USP47 5
- USP7 5
- USP6 5
- USP5 5
- USP43 5
- USP34 5
- USP28 5
- USP36 5
- USP37 5
- USP25 5
- USP18 5
- USP17L1 5
- USP17L4 5
- USP17L8 5
- USP17L3 5
- USP14 5
- USP17L2 5
- USP17L10 5
- USP17L11 5
- USP17L13 5
- USP17L15 5
- USP17L17 5
- USP17L18 5
- USP17L19 5
- USP17L20 5
- USP17L22 5
- USP17L24 5
- USP17L25 5
- USP17L26 5
- USP17L5 5
- USP17L27 5
- USP17L28 5
- USP17L29 5
- USP17L30 5
- USP50 5
- USP3 5
- USP30 5
- USP13 5
- USP40 5
- USP9Y 5
- USP41 5
- USP9X 5
- USP17L7 5
- USP26 5
- USP29 5
- USP17L23 5
Variants for USP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for USP1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114296661 | Benign: not provided | 62,450,639(+) |
A/G NM_003368.5(USP1):c.2016A>G (p.Gln672=) |
SYNONYMOUS | |
| rs140409730 | Benign: not provided | 62,445,230(+) |
C/T NM_003368.5(USP1):c.1050C>T (p.Ser350=) |
SYNONYMOUS | |
| rs751218576 | Not Provided: not provided | 62,450,600(+) |
CA/C NM_003368.5(USP1):c.1985del (p.Asn662fs) |
FRAMESHIFT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.84;
34.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for USP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP1 Gene
Disorders for USP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi anemia, complementation group i |
|
|
| mast syndrome |
|
|
| paranoid personality disorder |
|
|
| xeroderma pigmentosum, variant type |
|
|
| fanconi anemia, complementation group a |
|
|
Search USP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for USP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for USP1 Gene
Publications for USP1 Gene
- A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. (PMID: 18082604) Cohn MA … D'Andrea AD (Molecular cell 2007) 3 4 23
- Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. (PMID: 9806842) Fujiwara T … Tanaka K (Genomics 1998) 3 4 23
- Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. (PMID: 26388029) Yin J … Harris SF (Structure (London, England : 1993) 2015) 3 4
- CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. (PMID: 20129063) Terai K … Dutta A (Molecular cell 2010) 3 23
- Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. (PMID: 20147293) Lee KY … Myung K (The Journal of biological chemistry 2010) 3 23
ExternalLinks
Products for USP1 Gene
- Custom Antibody ServicesOriGene Antibodies for USP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for USP1
- Origene Custom Protein Services for USP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for USP1
- Browse OriGene Inhibitory RNA Products For USP1
- OriGene qPCR primer pairs for USP1
- OriGene qPCR primer pairs and template standards for USP1
- OriGene CRISPR knockouts for USP1
- RC208487
- RC208487L1
- RC208487L2
- RC208487L3
- RC208487L4
- RC218192
- RC218192L3
- RC218192L4
- RC218309
- RC218309L1
- RC218309L2
- RC218309L3
- RC218309L4
- RG208487
- RG218192
- RG218309
- RR214933
- RR214933L3
- RR214933L4
- MR210640L3V
- MR210640L4V
- RC208487L1V
- RC208487L2V
- RC208487L3V
- RC208487L4V
- RC218192L3V
- RC218192L4V
- RC218309L1V
- RC218309L2V
- RC218309L3V
- RC218309L4V
- RR214933L3V
- RR214933L4V
- MG210640
- MR210640
- MR210640L3
- MR210640L4
- MR231140
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For USP1
- Sino Biological Human cDNA Clone for USP1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for USP1
- Novus Biologicals proteins and lysates for USP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for USP1
- Abcam proteins for USP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for USP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for USP1 (AFLGC-USP1)
- ApexBio compounds for USP1
- VectorBuilder Custom and pre-made DNA vectors for USP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for USP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for USP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for USP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for USP1
- Addgene plasmids for USP1
- antibodies-online: Show 35 available USP1 Antibodies ranked by validation data
- Compare Top USP1 Antibodies
- antibodies-online: Search results for available USP1 related products ranked by validation data
- antibodies-online: Show 7 available USP1 Proteins ranked by validation data
- Compare Top USP1 Proteins
- Quality Products:
- Horizon Cell Lines for USP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for USP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for USP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for USP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USP1
- Boster Bio Antibodies for USP1
- Browse Boster Bio ELISA Kits
Sources for USP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB