Aliases for USF2 Gene
External Ids for USF2 Gene
Previous GeneCards Identifiers for USF2 Gene
This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
GeneCards Summary for USF2 Gene
USF2 (Upstream Transcription Factor 2, C-Fos Interacting) is a Protein Coding gene. Diseases associated with USF2 include Renal Dysplasia and Cowden Syndrome. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is USF1.
UniProtKB/Swiss-Prot Summary for USF2 Gene
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.