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Aliases for USF2 Gene

Aliases for USF2 Gene

  • Upstream Transcription Factor 2, C-Fos Interacting 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 12 3 4
  • Major Late Transcription Factor 2 3 4
  • BHLHb12 3 4
  • FIP 3 4
  • Upstream Transcription Factor 2 4
  • Upstream Stimulatory Factor 2 3
  • C-Fos Interacting Protein 3
  • FOS-Interacting Protein 4
  • BHLHB12 4

External Ids for USF2 Gene

Previous GeneCards Identifiers for USF2 Gene

  • GC19P036377
  • GC19P036208
  • GC19P040435
  • GC19P040451
  • GC19P035759
  • GC19P032268

Summaries for USF2 Gene

Entrez Gene Summary for USF2 Gene

  • This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

GeneCards Summary for USF2 Gene

USF2 (Upstream Transcription Factor 2, C-Fos Interacting) is a Protein Coding gene. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is USF1.

UniProtKB/Swiss-Prot for USF2 Gene

  • Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters.

Gene Wiki entry for USF2 Gene

Additional gene information for USF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USF2 Gene

Genomics for USF2 Gene

GeneHancer (GH) Regulatory Elements for USF2 Gene

Promoters and enhancers for USF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J035266 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.5 -517 4.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 USF2 ZNF599 HAUS5 TMEM147-AS1 KMT2B PROSER3 ZNF146 ZNF792 LIN37 ZNF565
GH19J035136 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -129.5 -129520 5.4 HDGF FOXA2 MLX ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 ZNF548 ENSG00000221857 FXYD7 FXYD1 ENSG00000279619 ZNF599 TMEM147-AS1 LSM14A HAUS5 ZNF792 KIAA0355
GH19J035202 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -63.4 -63437 6.1 HDGF PKNOX1 SMAD1 ARNT YBX1 IRF4 POLR2B ZNF766 CBX5 ZNF207 LOC105372379 ZNF599 HAUS5 KIAA0355 FXYD5 ZNF792 TMEM147-AS1 USF2 FAM187B LSR
GH19J035208 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -56.6 -56554 7.1 PKNOX1 CLOCK FOXA2 SMAD1 FEZF1 ZNF2 IRF4 SP3 SP5 JUNB ZNF599 TMEM147-AS1 HAUS5 KIAA0355 PROSER3 MAG ZNF792 SDHAF1 USF2 ENSG00000267049
GH19J035217 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -51.8 -51777 1.2 BCOR CTCF ESRRA USF1 ZNF777 ZMYM3 REST RAD21 MITF RBAK TMEM147-AS1 USF2 ZNF146 SDHAF1 ZNF599 HAUS5 HAMP KIAA0355 MAG FFAR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USF2 gene promoter:

Genomic Locations for USF2 Gene

Genomic Locations for USF2 Gene
chr19:35,268,978-35,279,821
(GRCh38/hg38)
Size:
10,844 bases
Orientation:
Plus strand
chr19:35,759,881-35,770,724
(GRCh37/hg19)

Genomic View for USF2 Gene

Genes around USF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USF2 Gene

Proteins for USF2 Gene

  • Protein details for USF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15853-USF2_HUMAN
    Recommended name:
    Upstream stimulatory factor 2
    Protein Accession:
    Q15853
    Secondary Accessions:
    • O00671
    • O00709
    • Q05750
    • Q07952
    • Q15851
    • Q15852
    • Q6FI33
    • Q6YI47

    Protein attributes for USF2 Gene

    Size:
    346 amino acids
    Molecular mass:
    36955 Da
    Quaternary structure:
    • Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The USF1/USF2B heterodimer accounted for almost 15% in some cell.

    Alternative splice isoforms for USF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USF2 Gene

Post-translational modifications for USF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USF2 Gene

Domains & Families for USF2 Gene

Gene Families for USF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for USF2 Gene

Suggested Antigen Peptide Sequences for USF2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with USF2: view

No data available for UniProtKB/Swiss-Prot for USF2 Gene

Function for USF2 Gene

Molecular function for USF2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters.
GENATLAS Biochemistry:
upstream stimulatory transcription factor 2,ubiquitously expressed,disrupted in t(6;19) with multicystic renal dysplasia (see also PUJO)

Phenotypes From GWAS Catalog for USF2 Gene

Gene Ontology (GO) - Molecular Function for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 1589769
genes like me logo Genes that share ontologies with USF2: view
genes like me logo Genes that share phenotypes with USF2: view

Animal Models for USF2 Gene

MGI Knock Outs for USF2:

Animal Model Products

CRISPR Products

Transcription Factor Targets for USF2 Gene

Selected GeneGlobe predicted Target genes for USF2
Targeted motifs for USF2 Gene
HOMER Transcription Factor Regulatory Elements motif USF2
  • Consensus sequence: GTCACGTGGT Submotif: canonical Cell Type: C2C12 GEO ID: GSE36030

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USF2

Clone Products

  • Addgene plasmids for USF2

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for USF2 Gene

Localization for USF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USF2 gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8576131
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with USF2: view

Pathways & Interactions for USF2 Gene

genes like me logo Genes that share pathways with USF2: view

Pathways by source for USF2 Gene

Gene Ontology (GO) - Biological Process for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose IC 8576131
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with USF2: view

No data available for SIGNOR curated interactions for USF2 Gene

Drugs & Compounds for USF2 Gene

(6) Drugs for USF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for USF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with USF2: view

Transcripts for USF2 Gene

Unigene Clusters for USF2 Gene

Upstream transcription factor 2, c-fos interacting:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for USF2

Clone Products

  • Addgene plasmids for USF2

Alternative Splicing Database (ASD) splice patterns (SP) for USF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - -
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:

Relevant External Links for USF2 Gene

GeneLoc Exon Structure for
USF2
ECgene alternative splicing isoforms for
USF2

Expression for USF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USF2 Gene

Protein differential expression in normal tissues from HIPED for USF2 Gene

This gene is overexpressed in CD8 Tcells (16.2), Blymphocyte (11.4), Pancreas (10.3), Peripheral blood mononuclear cells (10.2), Placenta (6.9), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USF2 Gene



Protein tissue co-expression partners for USF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of USF2 Gene:

USF2

SOURCE GeneReport for Unigene cluster for USF2 Gene:

Hs.454534

mRNA Expression by UniProt/SwissProt for USF2 Gene:

Q15853-USF2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for USF2 Gene

  • Nervous system(5)
  • Liver(4.6)
  • Blood(4.4)
  • Eye(3.2)
  • Muscle(2.7)
  • Intestine(2.5)
  • Kidney(2.4)
  • Spleen(2.4)
  • Lung(2.3)
  • Heart(2.2)
  • Pancreas(2.2)
  • Skin(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with USF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for USF2 Gene

Orthologs for USF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USF2 34 33
  • 92.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Usf2 16 34 33
  • 92.49 (n)
rat
(Rattus norvegicus)
Mammalia Usf2 33
  • 92.2 (n)
chimpanzee
(Pan troglodytes)
Mammalia USF2 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USF2 34 33
  • 90.17 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USF2 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 78 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia USF2 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usf2 33
  • 76.59 (n)
Str.14981 33
zebrafish
(Danio rerio)
Actinopterygii usf2 34 33
  • 73.09 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Usf 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToMany
Cin.4872 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4872 33
Species where no ortholog for USF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USF2 Gene

ENSEMBL:
Gene Tree for USF2 (if available)
TreeFam:
Gene Tree for USF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for USF2: view image

Paralogs for USF2 Gene

Paralogs for USF2 Gene

(3) SIMAP similar genes for USF2 Gene using alignment to 8 proteins:

  • USF2_HUMAN
  • B4DLJ1_HUMAN
  • M0QXT0_HUMAN
  • M0QY46_HUMAN
  • M0QYU7_HUMAN
  • M0QZ39_HUMAN
  • M0R1C6_HUMAN
  • V9GYR5_HUMAN
genes like me logo Genes that share paralogs with USF2: view

Variants for USF2 Gene

Sequence variations from dbSNP and Humsavar for USF2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193920819 uncertain-significance, Malignant tumor of prostate 35,270,514(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs1000119262 -- 35,271,558(+) C/T intron_variant
rs1000208206 -- 35,274,573(+) G/A intron_variant
rs1000429501 -- 35,279,626(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001129625 -- 35,275,780(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USF2 Gene

Variant ID Type Subtype PubMed ID
dgv6416n54 CNV loss 21841781
dgv6417n54 CNV gain 21841781
dgv6418n54 CNV gain 21841781
dgv6419n54 CNV loss 21841781
esv2758758 CNV loss 17122850
esv27788 CNV loss 19812545
nsv1072881 CNV deletion 25765185
nsv1133449 CNV deletion 24896259
nsv510765 CNV deletion 20534489
nsv579389 CNV gain+loss 21841781
nsv579396 CNV gain 21841781
nsv579400 CNV gain+loss 21841781
nsv953283 CNV deletion 24416366

Variation tolerance for USF2 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.37; 81.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USF2 Gene

Disorders for USF2 Gene

Additional Disease Information for USF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for USF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USF2 Gene

Publications for USF2 Gene

  1. Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia. (PMID: 8954795) Groenen PM … Van de Ven WJ (Genomics 1996) 2 3 4 22 58
  2. Upstream stimulatory factor 2 is implicated in the progression of biliary atresia by regulation of hepcidin expression. (PMID: 18970934) Huang YH … Chen CL (Journal of pediatric surgery 2008) 3 22 44 58
  3. Isolation of a novel USF2 isoform: repressor of cathepsin B expression. (PMID: 15276216) Yan S … Sloane BF (Gene 2004) 3 4 22 58
  4. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. (PMID: 8576131) Viollet B … Martinez A (The Journal of biological chemistry 1996) 3 4 22 58
  5. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. (PMID: 1450663) Sirito M … Sawadogo M (Gene expression 1992) 3 4 22 58

Products for USF2 Gene

  • Addgene plasmids for USF2

Sources for USF2 Gene

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