Aliases for USF1 Gene
External Ids for USF1 Gene
Previous GeneCards Identifiers for USF1 Gene
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]
GeneCards Summary for USF1 Gene
USF1 (Upstream Transcription Factor 1) is a Protein Coding gene. Diseases associated with USF1 include Hyperlipidemia, Familial Combined, 1 and Hyperlipidemia, Familial Combined, 3. Among its related pathways are Signaling mediated by p38-alpha and p38-beta. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is USF2.
UniProtKB/Swiss-Prot Summary for USF1 Gene
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.