This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced t... See more...

Aliases for URI1 Gene

Aliases for URI1 Gene

  • URI1 Prefoldin Like Chaperone 2 3 5
  • RPB5-Mediating Protein 2 3 4
  • PPP1R19 2 3 4
  • NNX3 2 3 4
  • RMP 2 3 4
  • URI 2 3 4
  • RNA Polymerase II Subunit 5-Mediating Protein 3 4
  • Protein Phosphatase 1, Regulatory Subunit 19 2 3
  • Unconventional Prefoldin RPB5 Interactor 1 3 4
  • C19orf2 3 4
  • Protein Phosphatase 1 Regulatory Subunit 19 4
  • Unconventional Prefoldin RPB5 Interactor 2
  • Chromosome 19 Open Reading Frame 2 2
  • Protein NNX3 4
  • FLJ10575 2
  • URI1 5

External Ids for URI1 Gene

Previous HGNC Symbols for URI1 Gene

  • C19orf2

Previous GeneCards Identifiers for URI1 Gene

  • GC19P030415

Summaries for URI1 Gene

Entrez Gene Summary for URI1 Gene

  • This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

GeneCards Summary for URI1 Gene

URI1 (URI1 Prefoldin Like Chaperone) is a Protein Coding gene. Diseases associated with URI1 include Far Eastern Spotted Fever and Ovarian Cancer. Among its related pathways are Apoptosis and Autophagy and Translational Control. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot Summary for URI1 Gene

  • Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
  • Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Gene Wiki entry for URI1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for URI1 Gene

Genomics for URI1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for URI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around URI1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for URI1

Genomic Locations for URI1 Gene

Genomic Locations for URI1 Gene
chr19:29,923,644-30,016,612
(GRCh38/hg38)
Size:
92,969 bases
Orientation:
Plus strand
chr19:30,414,551-30,506,616
(GRCh37/hg19)
Size:
92,066 bases
Orientation:
Plus strand

Genomic View for URI1 Gene

Genes around URI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URI1 Gene

Proteins for URI1 Gene

  • Protein details for URI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94763-RMP_HUMAN
    Recommended name:
    Unconventional prefoldin RPB5 interactor 1
    Protein Accession:
    O94763
    Secondary Accessions:
    • A8K805
    • H7BY42
    • Q8TC23
    • Q9UNU3

    Protein attributes for URI1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminal region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT. Interacts with TSC1 and TSC2 (PubMed:28561026). Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner (PubMed:28561026).
    SequenceCaution:
    • Sequence=AAH26184.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for URI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for URI1 Gene

Post-translational modifications for URI1 Gene

  • Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling.
  • Ubiquitination at Lys208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for URI1

No data available for DME Specific Peptides for URI1 Gene

Domains & Families for URI1 Gene

Gene Families for URI1 Gene

Protein Domains for URI1 Gene

InterPro:
Blocks:
  • Putative prefoldin chaperone
ProtoNet:

Suggested Antigen Peptide Sequences for URI1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ10575 fis, clone NT2RP2003295, highly similar to RNA polymerase II subunit 5-mediating protein (Q6NX55_HUMAN)
  • C19orf2 protein (Q8TC23_HUMAN)
  • C19orf2 protein (Q96C15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94763

UniProtKB/Swiss-Prot:

RMP_HUMAN :
  • Belongs to the RNA polymerase II subunit 5-mediating protein family.
Family:
  • Belongs to the RNA polymerase II subunit 5-mediating protein family.
genes like me logo Genes that share domains with URI1: view

Function for URI1 Gene

Molecular function for URI1 Gene

UniProtKB/Swiss-Prot Function:
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
UniProtKB/Swiss-Prot Function:
Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Phenotypes From GWAS Catalog for URI1 Gene

Gene Ontology (GO) - Molecular Function for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 9819440
GO:0003682 chromatin binding IBA,IDA 21730289
GO:0003714 transcription corepressor activity IMP 9819440
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 12737519
genes like me logo Genes that share ontologies with URI1: view
genes like me logo Genes that share phenotypes with URI1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for URI1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for URI1 Gene

Localization for URI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URI1 Gene

Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for URI1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 15367675
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS,IDA 15367675
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with URI1: view

Pathways & Interactions for URI1 Gene

PathCards logo

SuperPathways for URI1 Gene

genes like me logo Genes that share pathways with URI1: view

Pathways by source for URI1 Gene

2 Cell Signaling Technology pathways for URI1 Gene

Gene Ontology (GO) - Biological Process for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA,IDA 12737519
GO:0001558 regulation of cell growth IDA 21730289
GO:0006357 regulation of transcription by RNA polymerase II IMP 9819440
GO:0009615 response to virus IMP 9819440
GO:0010923 negative regulation of phosphatase activity IBA,IMP 17936702
genes like me logo Genes that share ontologies with URI1: view

No data available for SIGNOR curated interactions for URI1 Gene

Drugs & Compounds for URI1 Gene

No Compound Related Data Available

Transcripts for URI1 Gene

mRNA/cDNA for URI1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for URI1

Alternative Splicing Database (ASD) splice patterns (SP) for URI1 Gene

No ASD Table

Relevant External Links for URI1 Gene

GeneLoc Exon Structure for
URI1

Expression for URI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for URI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for URI1 Gene

This gene is overexpressed in Fetal Brain (12.9), Testis (11.6), Plasma (10.6), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for URI1 Gene



Protein tissue co-expression partners for URI1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for URI1

SOURCE GeneReport for Unigene cluster for URI1 Gene:

Hs.466391

mRNA Expression by UniProt/SwissProt for URI1 Gene:

O94763-RMP_HUMAN
Tissue specificity: Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.

Evidence on tissue expression from TISSUES for URI1 Gene

  • Liver(4.6)
  • Nervous system(2.8)
  • Kidney(2.8)
  • Blood(2.7)
  • Heart(2.7)
  • Muscle(2.7)
  • Skin(2.7)
  • Intestine(2.6)
  • Lung(2.5)
  • Spleen(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with URI1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for URI1 Gene

Orthologs for URI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for URI1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia URI1 30 31
  • 98.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia URI1 30 31
  • 88.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia URI1 30
  • 87.11 (n)
NNX3 31
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Uri1 30 17 31
  • 81.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Uri1 30
  • 80.93 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 73 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia URI1 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves URI1 30 31
  • 75.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia URI1 31
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia uri1 30
  • 66.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1937 30
Zebrafish
(Danio rerio)
Actinopterygii uri1 30 31
  • 62.7 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5067 31
  • 31 (a)
OneToOne
Species where no ortholog for URI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for URI1 Gene

ENSEMBL:
Gene Tree for URI1 (if available)
TreeFam:
Gene Tree for URI1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for URI1: view image

Paralogs for URI1 Gene

(1) SIMAP similar genes for URI1 Gene using alignment to 10 proteins:

  • RMP_HUMAN
  • F8W9T0_HUMAN
  • I3L0K5_HUMAN
  • I3L104_HUMAN
  • I3L130_HUMAN
  • I3L280_HUMAN
  • I3L2V7_HUMAN
  • I3L467_HUMAN
  • I3NI51_HUMAN
  • K7EQZ9_HUMAN

Pseudogenes.org Pseudogenes for URI1 Gene

genes like me logo Genes that share paralogs with URI1: view

No data available for Paralogs for URI1 Gene

Variants for URI1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for URI1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
746812 Likely Benign: not provided 29,986,353(+) G/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
748433 Likely Benign: not provided 29,986,383(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
782967 Benign: not provided 30,014,922(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
rs756055523 Benign: Abnormality of neuronal migration 29,923,724(+) C/A MISSENSE_VARIANT
rs863223392 Benign: Abnormality of neuronal migration 30,009,016(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for URI1 Gene

Structural Variations from Database of Genomic Variants (DGV) for URI1 Gene

Variant ID Type Subtype PubMed ID
dgv3509n100 CNV loss 25217958
dgv3510n100 CNV loss 25217958
dgv3511n100 CNV loss 25217958
dgv3512n100 CNV loss 25217958
dgv3513n100 CNV loss 25217958
esv2669011 CNV deletion 23128226
esv2718430 CNV deletion 23290073
esv3396786 CNV insertion 20981092
esv3428986 CNV insertion 20981092
esv3644128 CNV loss 21293372
esv3644130 CNV loss 21293372
esv3644131 CNV loss 21293372
esv3644132 CNV loss 21293372
nsv1063678 CNV loss 25217958
nsv1144872 CNV deletion 24896259
nsv519832 CNV gain 19592680
nsv579282 CNV loss 21841781
nsv579283 CNV loss 21841781
nsv828517 CNV gain 20364138
nsv953270 CNV duplication 24416366
nsv960823 CNV duplication 23825009

Variation tolerance for URI1 Gene

Residual Variation Intolerance Score: 6.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for URI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
URI1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URI1 Gene

Disorders for URI1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for URI1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
far eastern spotted fever
  • rickettsia heilongjiangensis spotted fever
ovarian cancer
  • ovarian cancer, somatic
prostate cancer
  • prostate cancer, somatic
amyotrophic lateral sclerosis 7
  • als7
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search URI1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with URI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for URI1 Gene

Publications for URI1 Gene

  1. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W … Murakami S (Cell research 2003) 3 4 23
  2. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. (PMID: 9819440) Dorjsuren D … Murakami S (Molecular and cellular biology 1998) 2 3 4
  3. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. (PMID: 9878255) Van Leuven F … Delabie J (Genomics 1998) 2 3 4
  4. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. (PMID: 28561026) Cloutier P … Coulombe B (Nature communications 2017) 3 4
  5. URI is an oncogene amplified in ovarian cancer cells and is required for their survival. (PMID: 21397856) Theurillat JP … Krek W (Cancer cell 2011) 3 4

Products for URI1 Gene

Sources for URI1 Gene