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This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
URI1 (URI1 Prefoldin Like Chaperone) is a Protein Coding gene. Diseases associated with URI1 include Far Eastern Spotted Fever and Ovarian Cancer. Among its related pathways are Apoptosis and Autophagy and Translational Control. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein phosphatase inhibitor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000993 | RNA polymerase II complex binding | IDA | 9819440 |
GO:0003682 | chromatin binding | IBA,IDA | 21730289 |
GO:0003714 | transcription corepressor activity | IMP | 9819440 |
GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 12737519 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 15367675 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | TAS,IDA | 15367675 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis and Autophagy | ||
2 | Translational Control |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA,IDA | 12737519 |
GO:0001558 | regulation of cell growth | IDA | 21730289 |
GO:0006357 | regulation of transcription by RNA polymerase II | IMP | 9819440 |
GO:0009615 | response to virus | IMP | 9819440 |
GO:0010923 | negative regulation of phosphatase activity | IBA,IMP | 17936702 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | URI1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | URI1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | URI1 30 |
|
||
NNX3 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Uri1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Uri1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | URI1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | URI1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | URI1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | uri1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1937 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | uri1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5067 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
746812 | Likely Benign: not provided | 29,986,353(+) | G/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
748433 | Likely Benign: not provided | 29,986,383(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
782967 | Benign: not provided | 30,014,922(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs756055523 | Benign: Abnormality of neuronal migration | 29,923,724(+) | C/A | MISSENSE_VARIANT | |
rs863223392 | Benign: Abnormality of neuronal migration | 30,009,016(+) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3509n100 | CNV | loss | 25217958 |
dgv3510n100 | CNV | loss | 25217958 |
dgv3511n100 | CNV | loss | 25217958 |
dgv3512n100 | CNV | loss | 25217958 |
dgv3513n100 | CNV | loss | 25217958 |
esv2669011 | CNV | deletion | 23128226 |
esv2718430 | CNV | deletion | 23290073 |
esv3396786 | CNV | insertion | 20981092 |
esv3428986 | CNV | insertion | 20981092 |
esv3644128 | CNV | loss | 21293372 |
esv3644130 | CNV | loss | 21293372 |
esv3644131 | CNV | loss | 21293372 |
esv3644132 | CNV | loss | 21293372 |
nsv1063678 | CNV | loss | 25217958 |
nsv1144872 | CNV | deletion | 24896259 |
nsv519832 | CNV | gain | 19592680 |
nsv579282 | CNV | loss | 21841781 |
nsv579283 | CNV | loss | 21841781 |
nsv828517 | CNV | gain | 20364138 |
nsv953270 | CNV | duplication | 24416366 |
nsv960823 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
far eastern spotted fever |
|
|
ovarian cancer |
|
|
prostate cancer |
|
|
amyotrophic lateral sclerosis 7 |
|
|
hepatocellular carcinoma |
|
|