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Aliases for URB1 Gene

Aliases for URB1 Gene

  • URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae) 2 3 5
  • Nucleolar Preribosomal-Associated Protein 1 2 3
  • Nucleolar Protein 254 KDa 3 4
  • C21orf108 3 4
  • NPA1 3 4
  • Nucleolar Pre-Ribosomal-Associated Protein 1 3
  • Chromosome 21 Open Reading Frame 108 2
  • URB1 Ribosome Biogenesis 1 Homolog 4
  • KIAA0539 4
  • NOP254 4

External Ids for URB1 Gene

Previous HGNC Symbols for URB1 Gene

  • C21orf108

Previous GeneCards Identifiers for URB1 Gene

  • GC21M032607
  • GC21M033683
  • GC21M019092

Summaries for URB1 Gene

GeneCards Summary for URB1 Gene

URB1 (URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for URB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URB1 Gene

Genomics for URB1 Gene

GeneHancer (GH) Regulatory Elements for URB1 Gene

Promoters and enhancers for URB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I032392 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.6 -0.2 -211 2.4 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 URB1-AS1 URB1 PAXBP1 EVA1C SCAF4 ENSG00000238390
GH21I032769 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 44.4 -378.3 -378327 3.9 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 PAXBP1 C21orf62-AS1 TMEM50B SON DONSON C21orf59 EVA1C MIS18A-AS1 URB1 MIS18A
GH21I032410 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 28.3 -20.1 -20131 5.4 ATF1 SIN3A FEZF1 ZNF48 ZNF121 GLIS2 KLF7 SP3 REST TSHZ1 EVA1C SCAF4 PAXBP1 URB1 C21orf59 MIS18A TCP10L URB1-AS1 ENSG00000252045 SNORA80A
GH21I032492 Enhancer 1.3 Ensembl ENCODE dbSUPER 40.3 -101.7 -101654 4.6 PKNOX1 ZNF493 ZNF529 ZFP64 FEZF1 BATF ZNF48 RFX5 ZNF213 EGR1 PAXBP1 TMEM50B SCAF4 EVA1C C21orf59 URB1 MIS18A PAXBP1-AS1 C21orf62-AS1 ENSG00000238390
GH21I032258 Enhancer 1.1 Ensembl ENCODE 39.9 +134.5 134525 0.6 FOXA2 ZNF493 ZFP64 ZNF213 ARID2 ZNF143 RUNX3 DEK ZNF202 ZC3H11A PAXBP1 SCAF4 EVA1C C21orf59 URB1 MIS18A PAXBP1-AS1 MIS18A-AS1 C21orf62-AS1 LINC00846
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around URB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the URB1 gene promoter:

Genomic Locations for URB1 Gene

Genomic Locations for URB1 Gene
82,009 bases
Minus strand

Genomic View for URB1 Gene

Genes around URB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URB1 Gene

Proteins for URB1 Gene

  • Protein details for URB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar pre-ribosomal-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DSE5
    • Q96NX1
    • Q9NYQ1

    Protein attributes for URB1 Gene

    2271 amino acids
    Molecular mass:
    254389 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URB1 Gene

Post-translational modifications for URB1 Gene

  • Ubiquitination at posLast=2323, isoforms=185, isoforms=376, posLast=399399, isoforms=616, posLast=10851085, posLast=13361336, isoforms=1786, and isoforms=1909
  • Modification sites at PhosphoSitePlus

Other Protein References for URB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URB1 Gene

Domains & Families for URB1 Gene

Gene Families for URB1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for URB1 Gene

Suggested Antigen Peptide Sequences for URB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with URB1: view

No data available for UniProtKB/Swiss-Prot for URB1 Gene

Function for URB1 Gene

Phenotypes From GWAS Catalog for URB1 Gene

Gene Ontology (GO) - Molecular Function for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
genes like me logo Genes that share ontologies with URB1: view

Animal Model Products

CRISPR Products

miRNA for URB1 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for URB1 Gene

Localization for URB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URB1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for URB1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus NAS 12429849
genes like me logo Genes that share ontologies with URB1: view

Pathways & Interactions for URB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with URB1: view

No data available for Pathways by source and SIGNOR curated interactions for URB1 Gene

Drugs & Compounds for URB1 Gene

No Compound Related Data Available

Transcripts for URB1 Gene

mRNA/cDNA for URB1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for URB1 Gene

URB1 ribosome biogenesis 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for URB1 Gene

No ASD Table

Relevant External Links for URB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for URB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for URB1 Gene

Protein differential expression in normal tissues from HIPED for URB1 Gene

This gene is overexpressed in Synovial fluid (45.5) and Vitreous humor (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for URB1 Gene

Protein tissue co-expression partners for URB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of URB1 Gene:


SOURCE GeneReport for Unigene cluster for URB1 Gene:


Evidence on tissue expression from TISSUES for URB1 Gene

  • Blood(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with URB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for URB1 Gene

Orthologs for URB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for URB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia URB1 33
  • 99 (n)
C21ORF108 34
  • 99 (a)
(Canis familiaris)
Mammalia URB1 33 34
  • 84.84 (n)
(Bos Taurus)
Mammalia URB1 33 34
  • 81.11 (n)
(Mus musculus)
Mammalia Urb1 33 16 34
  • 79.31 (n)
(Rattus norvegicus)
Mammalia Urb1 33
  • 78.9 (n)
(Monodelphis domestica)
Mammalia URB1 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
-- 34
  • 55 (a)
-- 34
  • 48 (a)
-- 34
  • 44 (a)
(Gallus gallus)
Aves LOC100857673 33
  • 62.74 (n)
URB1 34
  • 56 (a)
(Anolis carolinensis)
Reptilia URB1 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia urb1 33
  • 58.8 (n)
(Danio rerio)
Actinopterygii LOC100333650 33
  • 54.9 (n)
URB1 (2 of 2) 34
  • 46 (a)
URB1 (1 of 2) 34
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12499 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea T05H4.10 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for URB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for URB1 Gene

Gene Tree for URB1 (if available)
Gene Tree for URB1 (if available)

Paralogs for URB1 Gene

No data available for Paralogs for URB1 Gene

Variants for URB1 Gene

Sequence variations from dbSNP and Humsavar for URB1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs114530014 likely-benign, Glucocorticoid Deficiency 32,311,866(-) C/T 3_prime_UTR_variant
rs142897309 uncertain-significance, Glucocorticoid Deficiency 32,311,985(-) T/A/C 3_prime_UTR_variant
rs146788457 uncertain-significance, Glucocorticoid Deficiency 32,311,963(-) C/G 3_prime_UTR_variant
rs17855143 likely-benign, Glucocorticoid Deficiency 32,311,867(-) C/G 3_prime_UTR_variant
rs200448756 uncertain-significance, Glucocorticoid Deficiency 32,311,923(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for URB1 Gene

Variant ID Type Subtype PubMed ID
esv3307785 CNV mobile element insertion 20981092
esv3405236 CNV insertion 20981092
esv3646883 CNV loss 21293372
nsv1139016 CNV deletion 24896259
nsv510795 CNV deletion 20534489
nsv834084 CNV gain 17160897
nsv834085 CNV gain 17160897

Variation tolerance for URB1 Gene

Gene Damage Index Score: 5.68; 72.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for URB1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URB1 Gene

Disorders for URB1 Gene

Additional Disease Information for URB1

No disorders were found for URB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for URB1 Gene

Publications for URB1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T … Nishimoto T (Nucleic acids research 2006) 3 4 58
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  5. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PMID: 10773462) Slavov D … Gardiner K (Gene 2000) 3 4 58

Products for URB1 Gene

Sources for URB1 Gene

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