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Aliases for UQCRC1 Gene
Aliases for UQCRC1 Gene
External Ids for UQCRC1 Gene
- HGNC: 12585
- Entrez Gene: 7384
- Ensembl: ENSG00000010256
- OMIM: 191328
- UniProtKB: P31930
Previous GeneCards Identifiers for UQCRC1 Gene
- GC03M048426
- GC03M047919
- GC03M048597
- GC03M048611
- GC03M048636
Summaries for UQCRC1 Gene
GeneCards Summary for UQCRC1 Gene
UQCRC1 (Ubiquinol-Cytochrome C Reductase Core Protein 1) is a Protein Coding gene. Diseases associated with UQCRC1 include Leukodystrophy, Hypomyelinating, 4 and Alzheimer Disease. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is PMPCB.
UniProtKB/Swiss-Prot Summary for UQCRC1 Gene
-
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).
Additional gene information for UQCRC1 Gene
- HGNC(12585)
- Entrez Gene(7384)
- Ensembl(ENSG00000010256)
- OMIM(191328)
- UniProtKB(P31930)
- Open Targets Platform(ENSG00000010256)
- Search for UQCRC1 at DataMed
- Search for UQCRC1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UQCRC1 Gene
Genomics for UQCRC1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UQCRC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UQCRC1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UQCRC1
- Top Transcription factor binding sites by QIAGEN in the UQCRC1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- GR
- GR-alpha
- GR-beta
- HNF-4alpha1
- HNF-4alpha2
- HOXA9
- MyoD
Genomic Locations for UQCRC1 Gene
Genomic Locations for UQCRC1 Gene
- chr3:48,599,002-48,610,976
- (GRCh38/hg38)
- Size:
- 11,975 bases
- Orientation:
- Minus strand
- chr3:48,636,432-48,648,409
- (GRCh37/hg19)
- Size:
- 11,978 bases
- Orientation:
- Minus strand
Genomic View for UQCRC1 Gene
Genes around UQCRC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by HGNC
- 3p21.31 by Entrez Gene
- 3p21.31 by Ensembl
UQCRC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UQCRC1 Gene
Proteins for UQCRC1 Gene
-
Protein details for UQCRC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31930-QCR1_HUMAN
- Recommended name:
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Protein Accession:
- P31930
- B2R7R8
- Q96DD2
Protein attributes for UQCRC1 Gene
- Size:
- 480 amino acids
- Molecular mass:
- 52646 Da
- Quaternary structure:
-
- Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695).
Protein Expression for UQCRC1 Gene
Post-translational modifications for UQCRC1 Gene
Other Protein References for UQCRC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ UQCRC1 Antibody
- BioLegend UQCRC1 Antibody (696202), UQCRC1 Antibody (697602), and UQCRC1 Antibody (697601)
- Novus Biologicals Antibodies for UQCRC1
-
Abcam antibodies for UQCRC1
- Invitrogen Antibodies for UQCRC1 (AFLGC-UQCRC1)
-
Boster Bio Antibodies for UQCRC1
- Sino Biological Antibodies for UQCRC1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for UQCRC1
- Origene Custom Protein Services for UQCRC1
- ProSpec Recombinant Proteins for UQCRC1
-
Signalway Proteins for UQCRC1
-
Abcam proteins for UQCRC1
Assay Products
- antibodies-online: Show 7 available UQCRC1 Elisa Kits ranked by validation data
- Compare Top UQCRC1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for UQCRC1 Gene
Domains & Families for UQCRC1 Gene
Gene Families for UQCRC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for UQCRC1 Gene
- InterPro:
- Blocks:
-
- Insulinase-like peptidase, family M16
- ProtoNet:
Suggested Antigen Peptide Sequences for UQCRC1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquinol-cytochrome-c reductase complex core protein 1 (QCR1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P31930- Family:
-
- Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.
Function for UQCRC1 Gene
Molecular function for UQCRC1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).
- GENATLAS Biochemistry:
- ubiquinol cytochrome c reductase,core protein 1,component of complex III of mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
Phenotypes From GWAS Catalog for UQCRC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0008121 | ubiquinol-cytochrome-c reductase activity | TAS | 8407948 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 19725078 |
| GO:0044877 | protein-containing complex binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for UQCRC1 Gene
- MGI mutant phenotypes for UQCRC1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UQCRC1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased Salmonella enterica Typhimurium invasion
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- shRNA abundance <= 25%
- Increased transferrin (TF) endocytosis
- Decreased vesicular stomatitis virus (VSV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased shRNA abundance
Animal Models for UQCRC1 Gene
- MGI Knock Outs for UQCRC1:
-
- Uqcrc1 Uqcrc1<tm1Zzuo>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UQCRC1 - Select products 50% OFF >
- * UQCRC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UQCRC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UQCRC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for UQCRC1
miRNA for UQCRC1 Gene
- miRTarBase miRNAs that target UQCRC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UQCRC1
- Browse OriGene Inhibitory RNA Products For UQCRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCRC1
Clone Products
- Applied Biological Materials (abm): Clones for UQCRC1 - Select products 50% OFF >
- * UQCRC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UQCRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UQCRC1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UQCRC1 Gene
Localization for UQCRC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UQCRC1 Gene
- Mitochondrion inner membrane. Peripheral membrane protein. Matrix side.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Mitochondria (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IBA,IDA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005746 | mitochondrial respiratory chain | TAS | 8407948 |
| GO:0005750 | mitochondrial respiratory chain complex III | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for UQCRC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Parkinson disease | ||
| 3 | Metabolism |
.40
|
|
| 4 | Cardiac muscle contraction | ||
Pathways by source for UQCRC1 Gene
1 BioSystems pathway for UQCRC1 Gene
8 KEGG pathways for UQCRC1 Gene
Interacting Proteins for UQCRC1 Gene
Selected Interacting proteins:
P31930-QCR1_HUMAN
ENSP00000203407
for UQCRC1 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for UQCRC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006119 | oxidative phosphorylation | TAS | 8407948 |
| GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | IEA,TAS | -- |
| GO:0009060 | aerobic respiration | TAS | 8407948 |
| GO:0014823 | response to activity | IEA | -- |
| GO:0043279 | response to alkaloid | IEA | -- |
No data available for SIGNOR curated interactions for UQCRC1 Gene
Drugs & Compounds for UQCRC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ubiquinone-2 | Experimental | Pharma | Target | 0 | ||
| (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | Experimental | Pharma | Target | 0 | ||
| (S)-famoxadone | Experimental | Pharma | Target | 0 | ||
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | Experimental | Pharma | Target | 0 | ||
| 2-Nonyl-4-quinolinol 1-oxide | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| QH2 |
|
56275-39-9 |
|
Transcripts for UQCRC1 Gene
mRNA/cDNA for UQCRC1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000203407 1595 nts (view in UCSC)
- ENST00000412343 778 nts (view in UCSC)
- ENST00000415995 1387 nts (view in UCSC)
- ENST00000460105 622 nts (view in UCSC)
- ENST00000463708 739 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UQCRC1 - Select products 50% OFF >
- * UQCRC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UQCRC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UQCRC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for UQCRC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UQCRC1
- Browse OriGene Inhibitory RNA Products For UQCRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCRC1
Clone Products
- Applied Biological Materials (abm): Clones for UQCRC1 - Select products 50% OFF >
- * UQCRC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UQCRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UQCRC1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - |
Relevant External Links for UQCRC1 Gene
- GeneLoc Exon Structure for
- UQCRC1
Expression for UQCRC1 Gene
mRNA differential expression in normal tissues according to GTEx for UQCRC1 Gene
This gene is overexpressed in Heart - Left Ventricle (x5.9) and Muscle - Skeletal (x4.4).
This gene is overexpressed in Heart (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UQCRC1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UQCRC1
SOURCE GeneReport for Unigene cluster for UQCRC1 Gene:
Hs.119251Evidence on tissue expression from TISSUES for UQCRC1 Gene
- Nervous system(5)
- Liver(4.6)
- Skin(4.5)
- Heart(4.4)
- Bone marrow(4.4)
- Lung(4)
- Intestine(4)
- Muscle(3.9)
- Kidney(3.4)
- Eye(3.1)
- Pancreas(2.8)
- Blood(2.8)
- Stomach(2.4)
- Adrenal gland(2.4)
- Thyroid gland(2.3)
- Lymph node(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for UQCRC1
-
OriGene qPCR primer pairs and template standards for UQCRC1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCRC1 Gene
Orthologs for UQCRC1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UQCRC1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UQCRC1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UQCRC1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Uqcrc1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Uqcrc1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | UQCRC1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UQCRC1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | UQCRC1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UQCRC1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | uqcrc1 30 |
|
||
| Str.7650 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53748 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | uqcrc1 30 31 |
|
OneToOne | |
| zgc73404 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG3731 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ucr-1 30 31 |
|
ManyToMany | |
| ZC410.2 32 |
|
|
|||
| mppb-1 31 |
|
ManyToMany | |||
| F56D2.1 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MAS1 31 |
|
OneToMany | |
| COR1 33 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3431 31 |
|
OneToMany |
- Species where no ortholog for UQCRC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UQCRC1 Gene
- ENSEMBL:
- Gene Tree for UQCRC1 (if available)
- TreeFam:
- Gene Tree for UQCRC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UQCRC1: view image
Paralogs for UQCRC1 Gene
Variants for UQCRC1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UQCRC1 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs144710790 | - | p.Asn301Ser | |||
| rs17080284 | - | p.Asp215His |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.46;
54.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UQCRC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UQCRC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRC1 Gene
Disorders for UQCRC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukodystrophy, hypomyelinating, 4 |
|
|
| alzheimer disease |
|
|
| leber optic atrophy |
|
|
Search UQCRC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UQCRC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UQCRC1 Gene
Publications for UQCRC1 Gene
- Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase. (PMID: 8407948) Hoffman GG … Greenspan DS (The Journal of biological chemistry 1993) 2 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer. (PMID: 16775426) Kulawiec M … Singh KK (Cancer biology & therapy 2006) 3 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PMID: 15242332) Aboulaich N … Vener AV (The Biochemical journal 2004) 3 4
ExternalLinks
Products for UQCRC1 Gene
- Custom Antibody ServicesOriGene Antibodies for UQCRC1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for UQCRC1
- Origene Custom Protein Services for UQCRC1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UQCRC1
- Browse OriGene Inhibitory RNA Products For UQCRC1
- OriGene qPCR primer pairs for UQCRC1
- OriGene qPCR primer pairs and template standards for UQCRC1
- OriGene CRISPR knockouts for UQCRC1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For UQCRC1
- Sino Biological Human cDNA Clone for UQCRC1
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for UQCRC1
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for UQCRC1
- Novus Biologicals proteins and lysates for UQCRC1
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- Abcam antibodies for UQCRC1
- Abcam proteins for UQCRC1
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- VectorBuilder Custom and pre-made DNA vectors for UQCRC1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for UQCRC1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for UQCRC1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for UQCRC1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UQCRC1
- antibodies-online: Show 23 available UQCRC1 Antibodies ranked by validation data
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- antibodies-online: Show 7 available UQCRC1 Elisa Kits ranked by validation data
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- antibodies-online: Search results for available UQCRC1 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UQCRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UQCRC1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UQCRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCRC1
- Boster Bio Antibodies for UQCRC1
- Browse Boster Bio ELISA Kits
- Signalway Proteins for UQCRC1
Sources for UQCRC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB