This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009] See more...

Aliases for UQCR11 Gene

Aliases for UQCR11 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI 2 3 5
  • Complex III Subunit 10 2 3 4
  • Ubiquinol-Cytochrome C Reductase Complex 6.4 KDa Protein 3 4
  • Ubiquinol-Cytochrome C Reductase, 6.4kDa Subunit 2 3
  • Cytochrome B-C1 Complex Subunit 10 3 4
  • Complex III Subunit XI 3 4
  • QCR10 2 3
  • UQCR 3 4
  • 0710008D09Rik 3
  • UQCR11 5

External Ids for UQCR11 Gene

Previous HGNC Symbols for UQCR11 Gene

  • UQCR

Previous GeneCards Identifiers for UQCR11 Gene

  • GC19M001371

Summaries for UQCR11 Gene

Entrez Gene Summary for UQCR11 Gene

  • This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]

GeneCards Summary for UQCR11 Gene

UQCR11 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI) is a Protein Coding gene. Diseases associated with UQCR11 include Gracile Syndrome. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. Gene Ontology (GO) annotations related to this gene include electron transfer activity and ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is ENSG00000267059.

UniProtKB/Swiss-Prot Summary for UQCR11 Gene

  • Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability.

Additional gene information for UQCR11 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UQCR11 Gene

Genomics for UQCR11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UQCR11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UQCR11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UQCR11

Genomic Locations for UQCR11 Gene

Genomic Locations for UQCR11 Gene
chr19:1,597,169-1,605,473
(GRCh38/hg38)
Size:
8,305 bases
Orientation:
Minus strand
chr19:1,597,154-1,605,483
(GRCh37/hg19)
Size:
8,330 bases
Orientation:
Minus strand

Genomic View for UQCR11 Gene

Genes around UQCR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCR11 Gene

Proteins for UQCR11 Gene

  • Protein details for UQCR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14957-QCR10_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 10
    Protein Accession:
    O14957
    Secondary Accessions:
    • B2R542
    • D6W5Z4
    • Q9UEA3
    • Q9UPK4

    Protein attributes for UQCR11 Gene

    Size:
    56 amino acids
    Molecular mass:
    6570 Da
    Quaternary structure:
    • Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695).

    Three dimensional structures from OCA and Proteopedia for UQCR11 Gene

neXtProt entry for UQCR11 Gene

Post-translational modifications for UQCR11 Gene

  • Ubiquitination at Lys51

Other Protein References for UQCR11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCR11 Gene

Domains & Families for UQCR11 Gene

Gene Families for UQCR11 Gene

Protein Domains for UQCR11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UQCR11 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquinol-cytochrome c reductase complex 6.4 kDa protein (QCR10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14957

UniProtKB/Swiss-Prot:

QCR10_HUMAN :
  • Belongs to the UQCR11/QCR10 family.
Family:
  • Belongs to the UQCR11/QCR10 family.
genes like me logo Genes that share domains with UQCR11: view

Function for UQCR11 Gene

Molecular function for UQCR11 Gene

UniProtKB/Swiss-Prot Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability.

Phenotypes From GWAS Catalog for UQCR11 Gene

Gene Ontology (GO) - Molecular Function for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity IBA 21873635
GO:0009055 electron transfer activity TAS 9161705
genes like me logo Genes that share ontologies with UQCR11: view
genes like me logo Genes that share phenotypes with UQCR11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCR11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCR11 Gene

Localization for UQCR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR11 Gene

Mitochondrion inner membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UQCR11 gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with UQCR11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UQCR11 Gene

Pathways & Interactions for UQCR11 Gene

genes like me logo Genes that share pathways with UQCR11: view

Gene Ontology (GO) - Biological Process for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9161705
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with UQCR11: view

No data available for SIGNOR curated interactions for UQCR11 Gene

Drugs & Compounds for UQCR11 Gene

(9) Drugs for UQCR11 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved, Experimental Pharma 1560
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
(S)-famoxadone Experimental Pharma Target 0
2-Nonyl-4-quinolinol 1-oxide Experimental Pharma Target 0

(1) Additional Compounds for UQCR11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • CoQH2
  • Coenzymes QH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCR11: view

Transcripts for UQCR11 Gene

mRNA/cDNA for UQCR11 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCR11

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for UQCR11 Gene

GeneLoc Exon Structure for
UQCR11

Expression for UQCR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UQCR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCR11 Gene

This gene is overexpressed in Liver (x4.5).

Protein differential expression in normal tissues from HIPED for UQCR11 Gene

This gene is overexpressed in Testis (17.2), Gallbladder (7.1), Liver (6.4), and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UQCR11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UQCR11

SOURCE GeneReport for Unigene cluster for UQCR11 Gene:

Hs.8372

Evidence on tissue expression from TISSUES for UQCR11 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with UQCR11: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCR11 Gene

Orthologs for UQCR11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UQCR11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UQCR11 30
  • 100 (n)
-- 31
  • 100 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Uqcr11 30 17 31
  • 83.93 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia UQCR11 30 31
  • 83.93 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia UQCR11 30 31
  • 83.93 (n)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Uqcr11 30
  • 82.74 (n)
Oppossum
(Monodelphis domestica)
Mammalia UQCR11 31
  • 82 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 68 (a)
OneToMany
Chicken
(Gallus gallus)
Aves UQCR11 31
  • 57 (a)
OneToMany
Species where no ortholog for UQCR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for UQCR11 Gene

ENSEMBL:
Gene Tree for UQCR11 (if available)
TreeFam:
Gene Tree for UQCR11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UQCR11: view image

Paralogs for UQCR11 Gene

Paralogs for UQCR11 Gene

Pseudogenes.org Pseudogenes for UQCR11 Gene

genes like me logo Genes that share paralogs with UQCR11: view

Variants for UQCR11 Gene

Additional dbSNP identifiers (rs#s) for UQCR11 Gene

Structural Variations from Database of Genomic Variants (DGV) for UQCR11 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV gain+loss 17666407
nsv953942 CNV deletion 24416366

Variation tolerance for UQCR11 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UQCR11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UQCR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UQCR11 Gene

Disorders for UQCR11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UQCR11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gracile syndrome
  • growth retardation, amino aciduria, cholestasis, iron overload, lactic acidosis, and early death
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UQCR11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UQCR11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UQCR11 Gene

Publications for UQCR11 Gene

  1. Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences. (PMID: 9161705) Islam MM … Tanaka M (Biochemistry and molecular biology international 1997) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  5. Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2. (PMID: 28844695) Guo R … Yang M (Cell 2017) 4

Products for UQCR11 Gene

  • Signalway ELISA kits for UQCR11
  • Signalway Proteins for UQCR11

Sources for UQCR11 Gene