Aliases for UQCR10 Gene
- Ubiquinol-Cytochrome C Reductase, Complex III Subunit X 2 3 5
- UCRC 2 3 4
- Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa 2 3
- Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein 3 4
- Cytochrome C1 Non-Heme 7 KDa Protein 3 4
- Cytochrome B-C1 Complex Subunit 9 3 4
- Complex III Subunit 9 2 4
- HSPC051 2 3
External Ids for UQCR10 Gene
Previous GeneCards Identifiers for UQCR10 Gene
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 220.127.116.11), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
GeneCards Summary for UQCR10 Gene
UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Diseases associated with UQCR10 include Post-Vaccinal Encephalitis and Mitochondrial Complex Iii Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include ubiquinol-cytochrome-c reductase activity.
UniProtKB/Swiss-Prot Summary for UQCR10 Gene
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.