Aliases for UQCR10 Gene
Aliases for UQCR10 Gene
- Ubiquinol-Cytochrome C Reductase, Complex III Subunit X 2 3 5
- Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa 2 3
- Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein 3 4
- Cytochrome C1 Non-Heme 7 KDa Protein 3 4
- Cytochrome B-C1 Complex Subunit 9 3 4
- Complex III Subunit 9 2 4
- UCRC 3 4
- Ubiquinol-Cytochrome C Reductase Complex (7.2 KD) 3
External Ids for UQCR10 Gene
- HGNC: 30863
- Entrez Gene: 29796
- Ensembl: ENSG00000184076
- OMIM: 610843
- UniProtKB: Q9UDW1
Previous GeneCards Identifiers for UQCR10 Gene
- GC22P030163
- GC22P013126
Summaries for UQCR10 Gene
-
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
GeneCards Summary for UQCR10 Gene
UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include ubiquinol-cytochrome-c reductase activity.
UniProtKB/Swiss-Prot for UQCR10 Gene
-
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).
Additional gene information for UQCR10 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCR10 Gene
Genomics for UQCR10 Gene
GeneHancer (GH) Regulatory Elements for UQCR10 Gene
Promoters and enhancers for UQCR10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UQCR10 on UCSC Golden Path with GeneCards custom track
Genomic Locations for UQCR10 Gene
Genomic Locations for UQCR10 Gene
- chr22:29,767,369-29,770,413
- (GRCh38/hg38)
- Size:
- 3,045 bases
- Orientation:
- Plus strand
- chr22:30,163,358-30,166,402
- (GRCh37/hg19)
- Size:
- 3,045 bases
- Orientation:
- Plus strand
Genomic View for UQCR10 Gene
Genes around UQCR10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by HGNC
- 22q12.2 by Entrez Gene
- 22q12.2 by Ensembl
UQCR10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UQCR10 Gene
Proteins for UQCR10 Gene
-
Protein details for UQCR10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UDW1-QCR9_HUMAN
- Recommended name:
- Cytochrome b-c1 complex subunit 9
- Protein Accession:
- Q9UDW1
- B5MCM5
- Q9T2V6
Protein attributes for UQCR10 Gene
- Size:
- 63 amino acids
- Molecular mass:
- 7308 Da
- Quaternary structure:
-
- The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Protein Expression for UQCR10 Gene
Post-translational modifications for UQCR10 Gene
No Post-translational modifications
Other Protein References for UQCR10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
-
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-
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-
Abcam proteins for UQCR10
No data available for DME Specific Peptides for UQCR10 Gene
Domains & Families for UQCR10 Gene
Gene Families for UQCR10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for UQCR10 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UQCR10 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquinol-cytochrome c reductase complex 7.2 kDa protein (Q9UI02_HUMAN)
- Ubiquinol-cytochrome c reductase complex 7.2 kDa protein (QCR9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UDW1- Family:
-
- Belongs to the UQCR10/QCR9 family.
Function for UQCR10 Gene
Molecular function for UQCR10 Gene
- UniProtKB/Swiss-Prot Function:
- This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).
Phenotypes From GWAS Catalog for UQCR10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008121 | ubiquinol-cytochrome-c reductase activity | NAS | 8592474 |
Phenotypes for UQCR10 Gene
Animal Model Products
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-
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miRNA for UQCR10 Gene
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCR10 Gene
Localization for UQCR10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UQCR10 Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005750 | mitochondrial respiratory chain complex III | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0070469 | respiratory chain | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for UQCR10 Gene
Pathways & Interactions for UQCR10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Metabolism |
.40
|
|
| 3 | Cardiac muscle contraction | ||
Pathways by source for UQCR10 Gene
1 BioSystems pathway for UQCR10 Gene
8 KEGG pathways for UQCR10 Gene
Interacting Proteins for UQCR10 Gene
GPS-Prot Interaction Network for UQCR10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | NAS,TAS | -- |
| GO:0009060 | aerobic respiration | IBA | 21873635 |
| GO:0034551 | mitochondrial respiratory chain complex III assembly | IBA | 21873635 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for UQCR10 Gene
Drugs & Compounds for UQCR10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ubiquinone-2 | Experimental | Pharma | Target | 0 | ||
| (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | Experimental | Pharma | Target | 0 | ||
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | Experimental | Pharma | Target | 0 | ||
| 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE | Experimental | Pharma | Target | 0 | ||
| 5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| QH2 |
|
56275-39-9 |
|
Transcripts for UQCR10 Gene
mRNA/cDNA for UQCR10 Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (327) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330029 916 bps (ENST00000330029.6)
- ENST00000401406 584 bps (ENST00000401406.3)
Unigene Clusters for UQCR10 Gene
CRISPR Products
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miRNA Products
Inhibitory RNA Products
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Clone Products
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-
- MG200049
- MR200049
- MR200049L1
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- RG202816
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- RR215716
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Expression for UQCR10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (18.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UQCR10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of UQCR10 Gene:
UQCR10SOURCE GeneReport for Unigene cluster for UQCR10 Gene:
Hs.284292Evidence on tissue expression from TISSUES for UQCR10 Gene
- Heart(4.5)
- Liver(4.4)
- Blood(4.3)
- Bone marrow(4.3)
- Nervous system(2.4)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for UQCR10
-
OriGene qPCR primer pairs and template standards for UQCR10
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Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCR10 Gene
Orthologs for UQCR10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | UQCR10 34 |
|
||
| cow (Bos Taurus) |
Mammalia | UQCR10 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | UQCR10 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Uqcr10 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Uqcr10 34 |
|
||
| chicken (Gallus gallus) |
Aves | UQCR10 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | UQCR10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | uqcr10 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ox 35 |
|
OneToOne |
- Species where no ortholog for UQCR10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for UQCR10 Gene
- ENSEMBL:
- Gene Tree for UQCR10 (if available)
- TreeFam:
- Gene Tree for UQCR10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UQCR10: view image
Paralogs for UQCR10 Gene
Pseudogenes.org Pseudogenes for UQCR10 Gene
No data available for Paralogs for UQCR10 Gene
Variants for UQCR10 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000215510 | -- | 29,770,712(+) | T/C | downstream_transcript_variant | |
| rs1001496647 | -- | 29,769,359(+) | G/A | intron_variant | |
| rs1001821344 | -- | 29,768,967(+) | C/G | intron_variant | |
| rs1002449165 | -- | 29,767,529(+) | A/G | coding_sequence_variant, missense_variant | |
| rs1002884328 | -- | 29,767,128(+) | GGAG/GGAGGAG | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2453n106 | CNV | deletion | 24896259 |
| esv2724127 | CNV | deletion | 23290073 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv3590 | CNV | insertion | 18451855 |
| nsv515720 | CNV | gain+loss | 19592680 |
| nsv817987 | CNV | loss | 17921354 |
Residual Variation Intolerance Score:
79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.14;
80.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UQCR10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UQCR10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR10 Gene
Disorders for UQCR10 Gene
Additional Disease Information for UQCR10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for UQCR10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCR10 Gene
Publications for UQCR10 Gene
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
- Ubiquinol-cytochrome-c reductase from human and bovine mitochondria. (PMID: 8592474) Schägger H … von Jagow G (Methods in enzymology 1995) 3 4 58
ExternalLinks
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Sources for UQCR10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
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