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UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Diseases associated with UQCR10 include Post-Vaccinal Encephalitis and Mitochondrial Complex Iii Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include ubiquinol-cytochrome-c reductase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008121 | ubiquinol-cytochrome-c reductase activity | NAS | 8592474 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005750 | mitochondrial respiratory chain complex III | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
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2 | Pathways of neurodegeneration - multiple diseases | ||
3 | Metabolism |
.40
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4 | Prion disease |
.55
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|
5 | Cardiac muscle contraction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | NAS,TAS | -- |
GO:0009060 | aerobic respiration | IBA | 21873635 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ubiquinone-2 | Experimental | Pharma | Target | 0 | ||
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | Experimental | Pharma | Target | 0 | ||
(S)-famoxadone | Experimental | Pharma | Target | 0 | ||
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | Experimental | Pharma | Target | 0 | ||
2-Nonyl-4-quinolinol 1-oxide | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
QH2 |
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56275-39-9 |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UQCR10 30 |
|
||
Cow (Bos Taurus) |
Mammalia | UQCR10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UQCR10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Uqcr10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Uqcr10 30 |
|
||
Chicken (Gallus gallus) |
Aves | UQCR10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | UQCR10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | uqcr10 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ox 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs14115 | - |
p.Ile47Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2453n106 | CNV | deletion | 24896259 |
esv2724127 | CNV | deletion | 23290073 |
nsv1110864 | OTHER | inversion | 24896259 |
nsv3590 | CNV | insertion | 18451855 |
nsv515720 | CNV | gain+loss | 19592680 |
nsv817987 | CNV | loss | 17921354 |
Disorder | Aliases | PubMed IDs |
---|---|---|
post-vaccinal encephalitis |
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mitochondrial complex iii deficiency |
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