UQCR10 Gene (Protein Coding)

Ubiquinol-Cytochrome C Reductase, Complex III Subunit X

GC22P029767
GIFtS:
40
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008] See more...

Aliases for UQCR10 Gene

Aliases for UQCR10 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X 2 3 5
  • UCRC 2 3 4
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa 2 3
  • Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 7 KDa Protein 3 4
  • Cytochrome B-C1 Complex Subunit 9 3 4
  • Complex III Subunit 9 2 4
  • HSPC051 2 3
  • UCCR7.2 2 3
  • QCR9 2 3
  • Ubiquinol-Cytochrome C Reductase Complex (7.2 KD) 3
  • Cytochrome C1, Nonheme 7kDa Protein 3
  • Complex III Subunit X 4
  • HSPC119 3
  • HSPC151 3
  • UQCR10 5

External Ids for UQCR10 Gene

Previous GeneCards Identifiers for UQCR10 Gene

  • GC22P030163
  • GC22P013126

Summaries for UQCR10 Gene

Entrez Gene Summary for UQCR10 Gene

  • UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UQCR10 Gene

UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Diseases associated with UQCR10 include Post-Vaccinal Encephalitis and Mitochondrial Complex Iii Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot Summary for UQCR10 Gene

  • Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.

Gene Wiki entry for UQCR10 Gene

Additional gene information for UQCR10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UQCR10 Gene

Genomics for UQCR10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for UQCR10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UQCR10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UQCR10

Genomic Locations for UQCR10 Gene

Latest Assembly
chr22:29,767,369-29,770,413
(GRCh38/hg38)
Size:
3,045 bases
Orientation:
Plus strand

Previous Assembly
chr22:30,163,358-30,166,402
(GRCh37/hg19 by Entrez Gene)
Size:
3,045 bases
Orientation:
Plus strand

chr22:30,163,358-30,166,402
(GRCh37/hg19 by Ensembl)
Size:
3,045 bases
Orientation:
Plus strand

Genomic View for UQCR10 Gene

Genes around UQCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCR10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UQCR10 Gene

Proteins for UQCR10 Gene

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  • Protein details for UQCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDW1-QCR9_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Protein Accession:
    Q9UDW1
    Secondary Accessions:
    • B5MCM5
    • Q9T2V6

    Protein attributes for UQCR10 Gene

    Size:
    63 amino acids
    Molecular mass:
    7308 Da
    Quaternary structure:
    • Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695).

    Three dimensional structures from OCA and Proteopedia for UQCR10 Gene

    Alternative splice isoforms for UQCR10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UQCR10 Gene

Protein Expression for UQCR10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for UQCR10 Gene

No Post-translational modifications

Other Protein References for UQCR10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCR10 Gene

Domains & Families for UQCR10 Gene

Gene Families for UQCR10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for UQCR10 Gene

InterPro:
Blocks:
  • Ubiquinol-cytochrome C reductase, UQCRXQCR9 like
ProtoNet:

Suggested Antigen Peptide Sequences for UQCR10 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquinol-cytochrome c reductase complex 7.2 kDa protein (Q9UI02_HUMAN)
  • Ubiquinol-cytochrome c reductase complex 7.2 kDa protein (QCR9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UDW1

UniProtKB/Swiss-Prot:

QCR9_HUMAN :
  • Belongs to the UQCR10/QCR9 family.
Family:
  • Belongs to the UQCR10/QCR9 family.
genes like me logo Genes that share domains with UQCR10: view

Function for UQCR10 Gene

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Molecular function for UQCR10 Gene

UniProtKB/Swiss-Prot Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.

Phenotypes From GWAS Catalog for UQCR10 Gene

Gene Ontology (GO) - Molecular Function for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity NAS 8592474
genes like me logo Genes that share ontologies with UQCR10: view
genes like me logo Genes that share phenotypes with UQCR10: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCR10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCR10 Gene

Localization for UQCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR10 Gene

Mitochondrion inner membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UQCR10 gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005750 mitochondrial respiratory chain complex III IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UQCR10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UQCR10 Gene

Pathways & Interactions for UQCR10 Gene

genes like me logo Genes that share pathways with UQCR10: view

Gene Ontology (GO) - Biological Process for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c NAS,TAS --
GO:0009060 aerobic respiration IBA 21873635
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with UQCR10: view

No data available for SIGNOR curated interactions for UQCR10 Gene

Drugs & Compounds for UQCR10 Gene

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(12) Drugs for UQCR10 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
(S)-famoxadone Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-Nonyl-4-quinolinol 1-oxide Experimental Pharma Target 0

(1) Additional Compounds for UQCR10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • CoQH2
  • Coenzymes QH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
 56275-39-9
genes like me logo Genes that share compounds with UQCR10: view

Transcripts for UQCR10 Gene

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mRNA/cDNA for UQCR10 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UQCR10

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR10 Gene

No ASD Table

Relevant External Links for UQCR10 Gene

GeneLoc Exon Structure for
UQCR10

Expression for UQCR10 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UQCR10 Gene

mRNA expression in normal human tissues for UQCR10 Gene
mRNA expression by GTEx for UQCR10 GenemRNA expression by BioGPS for UQCR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UQCR10 Gene

This gene is overexpressed in Nasal epithelium (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UQCR10 Gene



Protein tissue co-expression partners for UQCR10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UQCR10

SOURCE GeneReport for Unigene cluster for UQCR10 Gene:

Hs.284292

Evidence on tissue expression from TISSUES for UQCR10 Gene

  • Heart(4.5)
  • Liver(4.5)
  • Blood(4.4)
  • Bone marrow(4.3)
  • Nervous system(2.9)
  • Muscle(2.8)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with UQCR10: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCR10 Gene

Orthologs for UQCR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCR10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia UQCR10 30
  • 100 (n)
Cow
(Bos Taurus)
 Mammalia UQCR10 30 31
  • 91.53 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia UQCR10 30 31
  • 91.01 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Uqcr10 30 17 31
  • 85.19 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Uqcr10 30
  • 84.66 (n)
Chicken
(Gallus gallus)
 Aves UQCR10 30 31
  • 79.17 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia UQCR10 31
  • 63 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia uqcr10 30
  • 66.67 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta ox 31
  • 55 (a)
 OneToOne
Species where no ortholog for UQCR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for UQCR10 Gene

ENSEMBL:
Gene Tree for UQCR10 (if available)
TreeFam:
Gene Tree for UQCR10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UQCR10: view image

Paralogs for UQCR10 Gene

Pseudogenes.org Pseudogenes for UQCR10 Gene

genes like me logo Genes that share paralogs with UQCR10: view

No data available for Paralogs for UQCR10 Gene

Variants for UQCR10 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UQCR10 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs14115 - p.Ile47Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UQCR10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UQCR10 Gene

Variant ID Type Subtype PubMed ID
dgv2453n106 CNV deletion 24896259
esv2724127 CNV deletion 23290073
nsv1110864 OTHER inversion 24896259
nsv3590 CNV insertion 18451855
nsv515720 CNV gain+loss 19592680
nsv817987 CNV loss 17921354

Variation tolerance for UQCR10 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.14; 80.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UQCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UQCR10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR10 Gene

Disorders for UQCR10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UQCR10 Gene - From: COP

Disorder Aliases PubMed IDs
post-vaccinal encephalitis
  • encephalitis following immunization procedures
mitochondrial complex iii deficiency
  • complex 3 mitochondrial respiratory chain deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UQCR10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UQCR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UQCR10 Gene

Publications for UQCR10 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
  5. Ubiquinol-cytochrome-c reductase from human and bovine mitochondria. (PMID: 8592474) Schägger H … von Jagow G (Methods in enzymology 1995) 3 4

ExternalLinks

View latest publications for UQCR10 gene in Mastermind

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Sources for UQCR10 Gene