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Aliases for UQCR10 Gene

Aliases for UQCR10 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X 2 3 5
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa 2 3
  • Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 7 KDa Protein 3 4
  • Complex III Subunit 9 2 4
  • UCRC 3 4
  • Ubiquinol-Cytochrome C Reductase Complex (7.2 KD) 3
  • Cytochrome C1, Nonheme 7kDa Protein 3
  • Cytochrome B-C1 Complex Subunit 9 3
  • Complex III Subunit X 4
  • HSPC051 3
  • HSPC119 3
  • HSPC151 3
  • UCCR7.2 3
  • QCR9 3

External Ids for UQCR10 Gene

Previous GeneCards Identifiers for UQCR10 Gene

  • GC22P030163
  • GC22P013126

Summaries for UQCR10 Gene

Entrez Gene Summary for UQCR10 Gene

  • UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UQCR10 Gene

UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for UQCR10 Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).

Gene Wiki entry for UQCR10 Gene

Additional gene information for UQCR10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCR10 Gene

Genomics for UQCR10 Gene

GeneHancer (GH) Regulatory Elements for UQCR10 Gene

Promoters and enhancers for UQCR10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I029765 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.1 -64 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 UQCR10 ZMAT5 HORMAD2-AS1 ASCC2 MTMR3
GH22I029600 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.9 -164.1 -164071 4.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 E2F8 NF2 GC22P029604 GC22P029605 GC22P029606 SF3A1 THOC5 EWSR1 CCDC117 NIPSNAP1 UQCR10
GH22I030201 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +440.4 440400 12.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 FOS SP5 LOC105372988 OSM TUG1 HORMAD2-AS1 MTMR3 MORC2 RNF215 EWSR1 PES1 THOC5
GH22I029733 Enhancer 1 ENCODE dbSUPER 7.1 -33.6 -33558 1.3 PKNOX1 NFIB ZNF335 TCF12 RCOR1 RUNX3 USF2 CEBPB TSHZ1 ZNF491 MTMR3 UQCR10 ASCC2 CABP7 GC22P029759 ZMAT5
GH22I029795 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.9 +31.6 31615 7.1 HDGF ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 ZNF766 ZNF143 FOS HORMAD2-AS1 ASCC2 ZMAT5 CABP7 UQCR10 ENSG00000237015
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UQCR10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for UQCR10 Gene

Genomic Locations for UQCR10 Gene
chr22:29,767,369-29,770,413
(GRCh38/hg38)
Size:
3,045 bases
Orientation:
Plus strand
chr22:30,163,358-30,166,402
(GRCh37/hg19)

Genomic View for UQCR10 Gene

Genes around UQCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCR10 Gene

Proteins for UQCR10 Gene

  • Protein details for UQCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDW1-QCR9_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Protein Accession:
    Q9UDW1
    Secondary Accessions:
    • B5MCM5
    • Q9T2V6

    Protein attributes for UQCR10 Gene

    Size:
    63 amino acids
    Molecular mass:
    7308 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Three dimensional structures from OCA and Proteopedia for UQCR10 Gene

    Alternative splice isoforms for UQCR10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UQCR10 Gene

Post-translational modifications for UQCR10 Gene

No Post-translational modifications

Other Protein References for UQCR10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCR10 Gene

Domains & Families for UQCR10 Gene

Protein Domains for UQCR10 Gene

Suggested Antigen Peptide Sequences for UQCR10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDW1

UniProtKB/Swiss-Prot:

QCR9_HUMAN :
  • Belongs to the UQCR10/QCR9 family.
Family:
  • Belongs to the UQCR10/QCR9 family.
genes like me logo Genes that share domains with UQCR10: view

Function for UQCR10 Gene

Molecular function for UQCR10 Gene

UniProtKB/Swiss-Prot Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).

Phenotypes From GWAS Catalog for UQCR10 Gene

Gene Ontology (GO) - Molecular Function for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity NAS 8592474
genes like me logo Genes that share ontologies with UQCR10: view
genes like me logo Genes that share phenotypes with UQCR10: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCR10 Gene

Localization for UQCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR10 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UQCR10 gene
Compartment Confidence
extracellular 5
mitochondrion 5
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005750 mitochondrial respiratory chain complex III IBA,IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with UQCR10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UQCR10 Gene

Pathways & Interactions for UQCR10 Gene

genes like me logo Genes that share pathways with UQCR10: view

Gene Ontology (GO) - Biological Process for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c NAS,TAS --
GO:0009060 aerobic respiration IBA --
GO:0034551 mitochondrial respiratory chain complex III assembly IBA --
GO:0055114 oxidation-reduction process IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with UQCR10: view

No data available for SIGNOR curated interactions for UQCR10 Gene

Drugs & Compounds for UQCR10 Gene

(12) Drugs for UQCR10 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE Experimental Pharma Target 0

(1) Additional Compounds for UQCR10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCR10: view

Transcripts for UQCR10 Gene

mRNA/cDNA for UQCR10 Gene

Unigene Clusters for UQCR10 Gene

Ubiquinol-cytochrome c reductase, complex III subunit X:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR10 Gene

No ASD Table

Relevant External Links for UQCR10 Gene

GeneLoc Exon Structure for
UQCR10
ECgene alternative splicing isoforms for
UQCR10

Expression for UQCR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UQCR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UQCR10 Gene

This gene is overexpressed in Nasal epithelium (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UQCR10 Gene



Protein tissue co-expression partners for UQCR10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UQCR10 Gene:

UQCR10

SOURCE GeneReport for Unigene cluster for UQCR10 Gene:

Hs.284292

Evidence on tissue expression from TISSUES for UQCR10 Gene

  • Heart(4.5)
  • Liver(4.4)
  • Blood(4.3)
  • Bone marrow(4.3)
  • Nervous system(2.4)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with UQCR10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCR10 Gene

Orthologs for UQCR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCR10 33
  • 100 (n)
cow
(Bos Taurus)
Mammalia UQCR10 33 34
  • 91.53 (n)
dog
(Canis familiaris)
Mammalia UQCR10 33 34
  • 91.01 (n)
mouse
(Mus musculus)
Mammalia Uqcr10 33 16 34
  • 85.19 (n)
rat
(Rattus norvegicus)
Mammalia Uqcr10 33
  • 84.66 (n)
chicken
(Gallus gallus)
Aves UQCR10 33 34
  • 79.17 (n)
lizard
(Anolis carolinensis)
Reptilia UQCR10 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uqcr10 33
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta ox 34
  • 55 (a)
OneToOne
Species where no ortholog for UQCR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UQCR10 Gene

ENSEMBL:
Gene Tree for UQCR10 (if available)
TreeFam:
Gene Tree for UQCR10 (if available)

Paralogs for UQCR10 Gene

Pseudogenes.org Pseudogenes for UQCR10 Gene

genes like me logo Genes that share paralogs with UQCR10: view

No data available for Paralogs for UQCR10 Gene

Variants for UQCR10 Gene

Sequence variations from dbSNP and Humsavar for UQCR10 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000215510 -- 29,770,712(+) T/C downstream_transcript_variant
rs1001496647 -- 29,769,359(+) G/A intron_variant
rs1001821344 -- 29,768,967(+) C/G intron_variant
rs1002449165 -- 29,767,529(+) A/G coding_sequence_variant, missense_variant
rs1002884328 -- 29,767,128(+) GGAG/GGAGGAG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UQCR10 Gene

Variant ID Type Subtype PubMed ID
nsv817987 CNV loss 17921354
nsv515720 CNV gain+loss 19592680
nsv3590 CNV insertion 18451855
nsv1110864 OTHER inversion 24896259
esv2724127 CNV deletion 23290073
dgv2453n106 CNV deletion 24896259

Variation tolerance for UQCR10 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.14; 80.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UQCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UQCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR10 Gene

Disorders for UQCR10 Gene

Additional Disease Information for UQCR10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UQCR10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCR10 Gene

Publications for UQCR10 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  5. Ubiquinol-cytochrome-c reductase from human and bovine mitochondria. (PMID: 8592474) Schägger H … von Jagow G (Methods in enzymology 1995) 3 4 58

Products for UQCR10 Gene

Sources for UQCR10 Gene

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