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Aliases for UPRT Gene

Aliases for UPRT Gene

  • Uracil Phosphoribosyltransferase Homolog 2 3 5
  • Uracil Phosphoribosyltransferase (FUR1) Homolog (S. Cerevisiae) 2
  • Uracil Phosphoribosyltransferase (FUR1) Homolog 3
  • UMP Pyrophosphorylase 3
  • RP11-311P8.3 3
  • EC 56
  • EC 2.4.2 56
  • UPRTase 3
  • FUR1 3
  • UPP 3

External Ids for UPRT Gene

Previous GeneCards Identifiers for UPRT Gene

  • GC0XP074411
  • GC0XP074412
  • GC0XP074493
  • GC0XP068128

Summaries for UPRT Gene

Entrez Gene Summary for UPRT Gene

  • This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]

GeneCards Summary for UPRT Gene

UPRT (Uracil Phosphoribosyltransferase Homolog) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism.

Additional gene information for UPRT Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPRT Gene

Genomics for UPRT Gene

GeneHancer (GH) Regulatory Elements for UPRT Gene

Promoters and enhancers for UPRT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI075273 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 559.2 +0.5 501 3 PKNOX1 ATF1 SIN3A YY1 FOS RUNX3 SP3 RXRA NFYC REST UPRT ABCB7 GC0XP075324
GH0XI075522 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 8.6 +249.1 249141 2 SMARCA5 MXI1 HCFC1 EBF1 ELF1 POLR2A NBN ZNF143 MLLT1 NR2C2 ZDHHC15 UPRT PIR41146
GH0XI074612 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 3.8 -659.9 -659900 3.1 PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 GLIS2 ELK1 ZNF207 ZNF143 RLIM RAB11FIP1P1 RN7SL648P UPRT PABPC1P3
GH0XI075546 Enhancer 0.2 ENCODE 4.3 +273.3 273277 2 UPRT PCNPP4 BRAFP1
GH0XI075278 Enhancer 0.3 ENCODE 0.4 +5.0 5018 1.3 GATA3 ZDHHC15 UPRT GC0XP075324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UPRT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UPRT gene promoter:

Genomic Locations for UPRT Gene

Genomic Locations for UPRT Gene
30,839 bases
Plus strand

Genomic View for UPRT Gene

Genes around UPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPRT Gene

Proteins for UPRT Gene

  • Protein details for UPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uracil phosphoribosyltransferase homolog
    Protein Accession:
    Secondary Accessions:
    • Q5JRL1
    • Q5JRL3
    • Q68DN0
    • Q96MW2

    Protein attributes for UPRT Gene

    309 amino acids
    Molecular mass:
    33786 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UPRT Gene


neXtProt entry for UPRT Gene

Selected DME Specific Peptides for UPRT Gene


Post-translational modifications for UPRT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UPRT Gene

Domains & Families for UPRT Gene

Gene Families for UPRT Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UPRT Gene


Suggested Antigen Peptide Sequences for UPRT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPRTase family.
  • Belongs to the UPRTase family.
genes like me logo Genes that share domains with UPRT: view

Function for UPRT Gene

Enzyme Numbers (IUBMB) for UPRT Gene

Gene Ontology (GO) - Molecular Function for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with UPRT: view
genes like me logo Genes that share phenotypes with UPRT: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UPRT Gene

Localization for UPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPRT Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UPRT gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with UPRT: view

Pathways & Interactions for UPRT Gene

genes like me logo Genes that share pathways with UPRT: view

Pathways by source for UPRT Gene

2 KEGG pathways for UPRT Gene

Gene Ontology (GO) - Biological Process for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0006222 UMP biosynthetic process IEA --
GO:0007565 female pregnancy IEA --
GO:0007595 lactation IEA --
GO:0009116 nucleoside metabolic process IEA --
genes like me logo Genes that share ontologies with UPRT: view

No data available for SIGNOR curated interactions for UPRT Gene

Drugs & Compounds for UPRT Gene

(2) Drugs for UPRT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uracil Experimental, Investigational Pharma 0
Uridine monophosphate Experimental Pharma 0

(2) Additional Compounds for UPRT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate
  • 5-Phospho-a-D-ribosyl pyrophosphate
  • 5-Phospho-alpha-D-ribose 1-diphosphate
  • 5-Phospho-alpha-D-ribose-1-diphosphate
  • 5-Phospho-alpha-D-ribosyl pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with UPRT: view

Transcripts for UPRT Gene

Unigene Clusters for UPRT Gene

Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -

Relevant External Links for UPRT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UPRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UPRT Gene

This gene is overexpressed in Urine (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UPRT Gene

NURSA nuclear receptor signaling pathways regulating expression of UPRT Gene:


SOURCE GeneReport for Unigene cluster for UPRT Gene:


mRNA Expression by UniProt/SwissProt for UPRT Gene:

Tissue specificity: Highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for UPRT Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with UPRT: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UPRT Gene

Orthologs for UPRT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UPRT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UPRT 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia UPRT 33 34
  • 91.72 (n)
(Canis familiaris)
Mammalia UPRT 33 34
  • 90.43 (n)
(Mus musculus)
Mammalia Uprt 33 16 34
  • 88.67 (n)
(Rattus norvegicus)
Mammalia Uprt 33
  • 88.35 (n)
(Ornithorhynchus anatinus)
Mammalia UPRT 34
  • 87 (a)
(Monodelphis domestica)
Mammalia UPRT 34
  • 74 (a)
(Gallus gallus)
Aves UPRT 33 34
  • 76.93 (n)
(Anolis carolinensis)
Reptilia UPRT 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia uprt 33
  • 78.16 (n)
Str.4444 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.31769 33
(Danio rerio)
Actinopterygii uprt 33 34
  • 70.43 (n)
Dr.11713 33
fruit fly
(Drosophila melanogaster)
Insecta CG5537 33 34
  • 60.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007111 33
  • 58.95 (n)
(Caenorhabditis elegans)
Secernentea C47B2.2 33 34
  • 55.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUR1 34 33
  • 55.68 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR052C 33
  • 53.51 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22903g 33
  • 51.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3454 34
  • 61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B3.01c 33
  • 55.56 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01446 33
  • 55.14 (n)
Species where no ortholog for UPRT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPRT Gene

Gene Tree for UPRT (if available)
Gene Tree for UPRT (if available)

Paralogs for UPRT Gene

(2) SIMAP similar genes for UPRT Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UPRT: view

No data available for Paralogs for UPRT Gene

Variants for UPRT Gene

Sequence variations from dbSNP and Humsavar for UPRT Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000581615 -- 75,295,442(+) G/A 3_prime_UTR_variant, intron_variant
rs1001048930 -- 75,280,328(+) G/A intron_variant
rs1001168909 -- 75,281,497(+) C/T intron_variant
rs1001275614 -- 75,274,367(+) A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001472023 -- 75,286,091(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UPRT Gene

Variant ID Type Subtype PubMed ID
esv25282 CNV gain 19812545

Variation tolerance for UPRT Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UPRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPRT Gene

Disorders for UPRT Gene

Additional Disease Information for UPRT

No disorders were found for UPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UPRT Gene

Publications for UPRT Gene

  1. UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan. (PMID: 26271729) Ghosh AC … O'Connor MB (Scientific reports 2015) 2 3 58
  2. Identification and characterization of human uracil phosphoribosyltransferase (UPRTase). (PMID: 17384901) Li J … Mao Y (Journal of human genetics 2007) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for UPRT Gene

Sources for UPRT Gene

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