Aliases for UPP1 Gene
External Ids for UPP1 Gene
Previous HGNC Symbols for UPP1 Gene
Previous GeneCards Identifiers for UPP1 Gene
This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]
GeneCards Summary for UPP1 Gene
UPP1 (Uridine Phosphorylase 1) is a Protein Coding gene. Diseases associated with UPP1 include Colorectal Cancer. Among its related pathways are Pyrimidine metabolism (KEGG) and Pyrimidine metabolism (REACTOME). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring pentosyl groups and uridine phosphorylase activity. An important paralog of this gene is UPP2.
UniProtKB/Swiss-Prot for UPP1 Gene
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.