This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the las... See more...

Aliases for UPF3B Gene

Aliases for UPF3B Gene

  • UPF3B Regulator Of Nonsense Mediated MRNA Decay 2 3 5
  • Up-Frameshift Suppressor 3 Homolog On Chromosome X 3 4
  • Regulator Of Nonsense Transcripts 3B 3 4
  • Up-Frameshift Suppressor 3 Homolog B 3 4
  • Nonsense MRNA Reducing Factor 3B 3 4
  • Mental Retardation, X-Linked 62 2 3
  • UPF3B Pseudogene 1 2 3
  • UPF3B Pseudogene 2 2 3
  • UPF3B Pseudogene 3 2 3
  • RENT3B 3 4
  • UPF3X 3 4
  • UPF3 Regulator Of Nonsense Transcripts Homolog B (Yeast) 2
  • UPF3 Regulator Of Nonsense Transcripts Homolog B 3
  • UPF3B, Regulator Of Nonsense Mediated MRNA Decay 2
  • HUpf3p-X 4
  • Upf3p-X 3
  • UPF3BP1 3
  • UPF3BP2 3
  • UPF3BP3 3
  • HUPF3B 3
  • MRXS14 3
  • HUpf3B 4
  • MRX82 3
  • MRX62 3

External Ids for UPF3B Gene

Previous HGNC Symbols for UPF3B Gene

  • MRX62
  • UPF3BP1
  • UPF3BP2
  • UPF3BP3

Previous GeneCards Identifiers for UPF3B Gene

  • GC0XM113785
  • GC0XM115953
  • GC0XM116943
  • GC0XM117722
  • GC0XM118749
  • GC0XM118852
  • GC0XM118967
  • GC0XM108461

Summaries for UPF3B Gene

Entrez Gene Summary for UPF3B Gene

  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UPF3B Gene

UPF3B (UPF3B Regulator Of Nonsense Mediated MRNA Decay) is a Protein Coding gene. Diseases associated with UPF3B include X-Linked Intellectual Disability With Marfanoid Habitus and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is UPF3A.

UniProtKB/Swiss-Prot Summary for UPF3B Gene

  • Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.

Gene Wiki entry for UPF3B Gene

Additional gene information for UPF3B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UPF3B Gene

Genomics for UPF3B Gene

GeneHancer (GH) Regulatory Elements for UPF3B Gene

Promoters and enhancers for UPF3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119851 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 521.7 +0.3 292 2.7 ZNF217 NRF1 POLR2G PHF8 SIX5 POLR2A ZBTB10 CLOCK ZBTB11 ZBTB26 UPF3B NKAPP1 SLC25A43 lnc-RNF113A-3 RF00017-8655
GH0XJ120308 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 49.4 -457.1 -457073 3 EP300 ZSCAN5C TCF12 ZNF639 CTCF ZNF10 ZIC2 ZBTB10 ZNF423 ZNF623 TMEM255A lnc-LAMP2-1 NKAPP1 UPF3B NKAP EEF1A1P30 LINC01402 RHOXF1 ZBTB33 CXorf56
GH0XJ119674 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.5 +168.3 168317 20.2 FOXK2 HNRNPK ZBTB40 EP300 CTCF ZSCAN5C SIN3A NRF1 POLR2G SP1 SEPTIN6 NKAPP1 UPF3B NKRF MIR766 CXorf56 LINC01402 EEF1A1P30 SLC25A5-AS1 CUL4B
GH0XJ119234 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 21.2 +616.0 616027 4.8 NRF1 USF1 POLR2G GTF2E2 PHF8 ZFX ZIC2 POLR2A ZBTB10 ZBTB26 PGRMC1 UPF3B FR772910-011
GH0XJ119869 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.7 -18.6 -18573 4.8 ZBTB40 ZNF217 ZNF300 POLR2G PHF8 SIX5 ZFX POLR2A ZBTB11 ZBTB26 RNF113A NDUFA1 NKAPP1 UPF3B RF00017-8657 RF00017-8655
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UPF3B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UPF3B

Top Transcription factor binding sites by QIAGEN in the UPF3B gene promoter:
  • AhR
  • AML1a
  • C/EBPalpha
  • Chx10
  • POU2F1
  • POU2F1a
  • TBP
  • TFIID
  • YY1

Genomic Locations for UPF3B Gene

Genomic Locations for UPF3B Gene
chrX:119,805,311-119,853,028
(GRCh38/hg38)
Size:
47,718 bases
Orientation:
Minus strand
chrX:118,967,985-118,986,991
(GRCh37/hg19)
Size:
19,007 bases
Orientation:
Minus strand

Genomic View for UPF3B Gene

Genes around UPF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPF3B Gene

Proteins for UPF3B Gene

  • Protein details for UPF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZI7-REN3B_HUMAN
    Recommended name:
    Regulator of nonsense transcripts 3B
    Protein Accession:
    Q9BZI7
    Secondary Accessions:
    • D3DWI3
    • D3DWI4
    • Q0VAK8
    • Q9H1J0

    Protein attributes for UPF3B Gene

    Size:
    483 amino acids
    Molecular mass:
    57762 Da
    Quaternary structure:
    • Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. The EJC core components EIF4A3 and the MAGOH-RBM8A dimer form a composite binding site for UPF3B which overlaps with the EJC binding site for WIBG (PubMed:16601204, PubMed:18066079, PubMed:23917022, PubMed:20479275). Interacts with EST1A, UPF2 and RBM8A (PubMed:12554878, PubMed:18066079, PubMed:15004547). Interacts with CPSF6 (PubMed:19864460).

    Three dimensional structures from OCA and Proteopedia for UPF3B Gene

    Alternative splice isoforms for UPF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPF3B Gene

Post-translational modifications for UPF3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for UPF3B

No data available for DME Specific Peptides for UPF3B Gene

Domains & Families for UPF3B Gene

Gene Families for UPF3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for UPF3B Gene

Suggested Antigen Peptide Sequences for UPF3B Gene

GenScript: Design optimal peptide antigens:
  • Up-frameshift suppressor 3 homolog on chromosome X (REN3B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZI7

UniProtKB/Swiss-Prot:

REN3B_HUMAN :
  • Belongs to the RENT3 family.
Family:
  • Belongs to the RENT3 family.
genes like me logo Genes that share domains with UPF3B: view

Function for UPF3B Gene

Molecular function for UPF3B Gene

UniProtKB/Swiss-Prot Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.

Phenotypes From GWAS Catalog for UPF3B Gene

Gene Ontology (GO) - Molecular Function for UPF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003729 mRNA binding IBA,IDA 11546873
GO:0005515 protein binding IPI 11163187
GO:0017056 structural constituent of nuclear pore NAS 11163187
genes like me logo Genes that share ontologies with UPF3B: view
genes like me logo Genes that share phenotypes with UPF3B: view

Human Phenotype Ontology for UPF3B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for UPF3B Gene

miRTarBase miRNAs that target UPF3B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UPF3B Gene

Localization for UPF3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPF3B Gene

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UPF3B gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UPF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,NAS 11163187
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA,NAS 11163187
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with UPF3B: view

Pathways & Interactions for UPF3B Gene

genes like me logo Genes that share pathways with UPF3B: view

SIGNOR curated interactions for UPF3B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UPF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0031124 mRNA 3'-end processing TAS --
genes like me logo Genes that share ontologies with UPF3B: view

Drugs & Compounds for UPF3B Gene

No Compound Related Data Available

Transcripts for UPF3B Gene

mRNA/cDNA for UPF3B Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPF3B Gene

No ASD Table

Relevant External Links for UPF3B Gene

GeneLoc Exon Structure for
UPF3B

Expression for UPF3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UPF3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UPF3B Gene

This gene is overexpressed in Lung (23.7), Peripheral blood mononuclear cells (7.7), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UPF3B Gene



Protein tissue co-expression partners for UPF3B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UPF3B

SOURCE GeneReport for Unigene cluster for UPF3B Gene:

Hs.103832

mRNA Expression by UniProt/SwissProt for UPF3B Gene:

Q9BZI7-REN3B_HUMAN
Tissue specificity: Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta.

Evidence on tissue expression from TISSUES for UPF3B Gene

  • Nervous system(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for UPF3B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • salivary gland
  • skull
  • tooth
  • vocal cord
Thorax:
  • aorta
  • chest wall
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • sternum
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with UPF3B: view

No data available for mRNA differential expression in normal tissues for UPF3B Gene

Orthologs for UPF3B Gene

This gene was present in the common ancestor of animals.

Orthologs for UPF3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPF3B 31 30
  • 97.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UPF3B 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPF3B 31 30
  • 93.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upf3b 30
  • 87.45 (n)
mouse
(Mus musculus)
Mammalia Upf3b 17 31 30
  • 86.67 (n)
oppossum
(Monodelphis domestica)
Mammalia UPF3B 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 69 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves UPF3B 31 30
  • 72.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UPF3B 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia upf3b 30
  • 62.59 (n)
Str.17708 30
zebrafish
(Danio rerio)
Actinopterygii upf3b 31 30
  • 62.46 (n)
OneToOne
zgc66390 30
fruit fly
(Drosophila melanogaster)
Insecta Upf3 31
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea smg-4 31
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2608 31
  • 33 (a)
OneToMany
Species where no ortholog for UPF3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPF3B Gene

ENSEMBL:
Gene Tree for UPF3B (if available)
TreeFam:
Gene Tree for UPF3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UPF3B: view image

Paralogs for UPF3B Gene

Paralogs for UPF3B Gene

(1) SIMAP similar genes for UPF3B Gene using alignment to 3 proteins:

  • REN3B_HUMAN
  • I3XIE4_HUMAN
  • Q0VAK7_HUMAN

Pseudogenes.org Pseudogenes for UPF3B Gene

genes like me logo Genes that share paralogs with UPF3B: view

Variants for UPF3B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UPF3B Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
11399 Pathogenic: Mental retardation, syndromic 14, X-linked 119,838,505(-) CCT/C FRAMESHIFT_VARIANT
670475 Benign: not provided 119,851,635(-) C/T INTRON_VARIANT
670828 Benign: not provided 119,853,088(-) G/A
670829 Benign: not provided 119,835,112(-) A/C INTRON_VARIANT
673765 Benign: not provided 119,843,369(-) A/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for UPF3B Gene

Structural Variations from Database of Genomic Variants (DGV) for UPF3B Gene

Variant ID Type Subtype PubMed ID
esv2758888 CNV gain 17122850

Variation tolerance for UPF3B Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UPF3B Gene

Human Gene Mutation Database (HGMD)
UPF3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UPF3B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPF3B Gene

Disorders for UPF3B Gene

MalaCards: The human disease database

(11) MalaCards diseases for UPF3B Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
x-linked intellectual disability with marfanoid habitus
  • lujan-fryns syndrome
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
lujan-fryns syndrome
  • mental retardation, x-linked, with marfanoid habitus
fryns syndrome
  • frns
syndromic x-linked intellectual disability
  • x-linked syndromic intellectual disability
- elite association - COSMIC cancer census association via MalaCards
Search UPF3B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

REN3B_HUMAN
  • Mental retardation, X-linked, syndromic, 14 (MRXS14) [MIM:300676]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXS14 patients manifest mental retardation associated with other variable signs such as autistic features, slender build, poor musculature, long, thin face, high-arched palate, high nasal bridge, and pectus deformities. {ECO:0000269 PubMed:17704778}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for UPF3B

genes like me logo Genes that share disorders with UPF3B: view

No data available for Genatlas for UPF3B Gene

Publications for UPF3B Gene

  1. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). (PMID: 11113196) Serin G … Maquat LE (Molecular and cellular biology 2001) 2 3 4 23 54
  2. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. (PMID: 11163187) Lykke-Andersen J … Steitz JA (Cell 2000) 2 3 4 23 54
  3. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. (PMID: 18066079) Chamieh H … Le Hir H (Nature structural & molecular biology 2008) 3 4 23 54
  4. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. (PMID: 16601204) Kunz JB … Gehring NH (RNA (New York, N.Y.) 2006) 3 4 23 54
  5. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. (PMID: 15004547) Kadlec J … Cusack S (Nature structural & molecular biology 2004) 3 4 23 54

Products for UPF3B Gene

Sources for UPF3B Gene